INT111473

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 44
Disease Relevance 1.35
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CES2) catabolic process (CES2)
Anatomy Link Frequency
liver 12
intestine 7
colon 2
skeletal muscle 2
spleen 2
CES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 3 86.68 High High
cocaine 41 64.36 Quite High
Analgesic 15 61.20 Quite High
Glutamate 29 41.76 Quite Low
lidocaine 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 41 97.28 Very High Very High Very High
Disease 29 72.60 Quite High
Heart Disease 29 64.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hybridization analyses showed that CES2 is highly expressed in the heart, skeletal muscle, colon, spleen, kidney and liver, but considerably less expressed in fetal tissues (e.g. fetal heart, kidney, spleen, and liver) and cancer cells.
Gene_expression (expressed) of CES2 in spleen associated with cancer
1) Confidence 0.78 Published 2003 Journal Pharmacogenetics Section Abstract Doc Link 12835618 Disease Relevance 0.09 Pain Relevance 0.09
Hybridization analyses showed that CES2 is highly expressed in the heart, skeletal muscle, colon, spleen, kidney and liver, but considerably less expressed in fetal tissues (e.g. fetal heart, kidney, spleen, and liver) and cancer cells.
Gene_expression (expressed) of CES2 in spleen associated with cancer
2) Confidence 0.78 Published 2003 Journal Pharmacogenetics Section Abstract Doc Link 12835618 Disease Relevance 0.10 Pain Relevance 0.09
Unlike the CES1 gene, the CES2.1 gene was expressed in the liver, but not in the small intestine.
Neg (not) Gene_expression (expressed) of CES2 in small intestine
3) Confidence 0.77 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Primers for the CES2.2 cDNA amplified an 800 bp PCR product, which was similar to the predicted PCR product (803 bp), indicating that the CES2.2 gene is expressed in liver and intestine.
Gene_expression (expressed) of CES2.2 in intestine
4) Confidence 0.77 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
These results indicate that the CES2.3 gene is expressed in both liver and small intestine and that the BLAT derived sequence contained a deletion as compared with the actual sequence for the CES2.3 RT-PCR product.
Gene_expression (expressed) of CES2 in liver
5) Confidence 0.77 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The best-scoring alignment in a BLAST analysis [36,37] for the opossum cDNA sequence was with a human CES2 sequence, and the opossum cDNA is referred to as CES2.1 (gene designation: CES2.1).
Gene_expression (sequence) of CES2
6) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0.20 Pain Relevance 0
The PCR product for the CES2.3 gene should have been 766 bp.
Gene_expression (product) of CES2
7) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
A phylogenetic tree (Figure 4) was estimated using a progressive alignment of 6 human CES amino acid sequences with the following opossum CES sequences: CES2.1 (derived from sequencing a full-length cDNA); CES1, CES2.2 and CES2.3 (derived from BLAT interrogations of the opossum genome and from sequencing cDNA clones of RT-PCR products for these genes); and CES6 (derived from blat interrogation of the opossum genome using human CES6) [39,40].
Gene_expression (products) of CES2.2
8) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The predicted amino acid sequence for opossum CES1 showed 63% identity with human CES1 and 46% identity with human CES2 supporting its designation within the CES1 family (Table 2).
Gene_expression (supporting) of CES2
9) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The amino acid distance tree (Figure 4) shows a cluster of five main groups consistent with CES1, CES2, CES3, CES6, and CES7 gene families being products of ancestral gene duplication events, and indicates that all families arose prior to the divergence of therian mammals ~173–193 MYA [45-47].
Gene_expression (products) of CES2
10) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
In addition to the extensive sequence similarities observed for the human CES2 and opossum CES2Like products, there are strong similarities in predicted secondary structures for these enzymes suggesting that the ??
Gene_expression (products) of CES2
11) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
In addition to the extensive sequence similarities observed for the human CES2 and opossum CES2Like products, there are strong similarities in predicted secondary structures for these enzymes suggesting that the ??
Gene_expression (products) of CES2Like
12) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Figure 2 and Table 2 show the amino acid sequence alignments, the predicted secondary structures and sequence identities for the predicted opossum CES1, multiple CES2Like and CES6Like proteins, as well as the six human CES gene products, previously described [16-26] (RS Holmes, J Glenn, JL VandeBerg & LA Cox: Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases, unpublished).
Gene_expression (products) of CES2Like
13) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
A phylogenetic tree (Figure 4) was estimated using a progressive alignment of 6 human CES amino acid sequences with the following opossum CES sequences: CES2.1 (derived from sequencing a full-length cDNA); CES1, CES2.2 and CES2.3 (derived from BLAT interrogations of the opossum genome and from sequencing cDNA clones of RT-PCR products for these genes); and CES6 (derived from blat interrogation of the opossum genome using human CES6) [39,40].
Gene_expression (products) of CES2
14) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The human CES2 C-terminal tetrapeptide sequence, His-Thr-Glu-Leu (HTEL), functions in protein retrieval from the Golgi apparatus and in CES retention in the ER lumen [12], but this is missing in opossum CES2.1 which may then influence the subcellular location and metabolic role for this enzyme in opossum liver.
Gene_expression (retention) of CES2 in liver
15) Confidence 0.67 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Phylogenetic analyses produced congruent phylogenetic trees depicting a rapid early diversification into at least five distinct CES gene family clusters: CES2, CES1, CES7, CES3, and CES6.
Gene_expression (produced) of CES2
16) Confidence 0.60 Published 2008 Journal BMC Evol Biol Section Abstract Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Opossum CES1 and multiple CES2 genes were expressed in liver and intestine.
Gene_expression (expressed) of CES2 in intestine
17) Confidence 0.60 Published 2008 Journal BMC Evol Biol Section Abstract Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
We report a cDNA sequence for an opossum CES and present evidence for CES1 and CES2 like genes expressed in opossum liver and intestine and for distinct gene locations of five opossum CES genes,CES1, CES2.1, CES2.2, CES2.3 and CES6, on chromosome 1.
Gene_expression (expressed) of CES2 in intestine
18) Confidence 0.60 Published 2008 Journal BMC Evol Biol Section Abstract Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
We report a cDNA sequence for an opossum CES and present evidence for CES1 and CES2 like genes expressed in opossum liver and intestine and for distinct gene locations of five opossum CES genes,CES1, CES2.1, CES2.2, CES2.3 and CES6, on chromosome 1.
Gene_expression (expressed) of CES2 in intestine
19) Confidence 0.60 Published 2008 Journal BMC Evol Biol Section Abstract Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
RT-PCR expression studies demonstrated that the opossum CES1, CES2.2 and CES2.3 genes are transcribed in opossum liver and intestine, whereas the opossum CES2.1 gene was expressed in liver and not intestine.
Gene_expression (expressed) of CES2 in intestine
20) Confidence 0.60 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0

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