INT111476

Context Info Confidence 0.76 First Reported 2003 Last Reported 2011 Negated 11 Speculated 2 Reported most in Body Documents 88 Total Number 90 Disease Relevance 61.08 Pain Relevance 11.64

cytosol (TP63) nucleoplasm (TP63) anatomical structure formation involved in morphogenesis (TP63) Golgi apparatus (TP63) nucleolus (TP63) nucleus (TP63)

Anatomy Link Frequency uterine 9 neurons 5 smooth muscle 4 skin 4 urine 4 TP63 (Homo sapiens) TP63 - P1308L (16) TP63 - R227Q (1)

Pain Link Frequency Relevance Heat pain pelvic 7 100.00 Somatostatin 3 100.00 dorsal root ganglion 527 99.82 antagonist 40 99.80 cytokine 244 99.34 Paroxysmal extreme pain disorder 544 99.24 hyperexcitability 34 99.24 Inflammation 174 99.16 Pain 323 99.12 endometriosis 20 99.08

Disease Link Frequency Relevance Heat Cancer 1797 100.00 Leiomyosarcoma 686 100.00 Chronic Pelvic Pain Syndrome 64 100.00 Apoptosis 62 100.00 Erythermalgia 527 99.92 Skin Cancer 297 99.84 Ganglion Cysts 561 99.82 Overactive Bladder 4 99.80 Syndrome 54 99.76 Psoriasis 204 99.72

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of p63 differs in peritoneal endometriosis, endometriomas, adenomyosis, rectovaginal septum endometriosis, and abdominal wall endometriosis.

Gene_expression (Expression) of p63 associated with endometriosis and dismenorea

1) Confidence 0.76 Published 2007 Journal Arch. Pathol. Lab. Med. Section Title Doc Link 17616998 Disease Relevance 0.67 Pain Relevance 0.29

OBJECTIVE: To determine whether p63 is expressed differently in peritoneal endometriosis, endometriomas, and adenomyosis, as well as in deep endometriotic nodules of the rectovaginal septum and abdominal wall.

Gene_expression (expressed) of p63 in nodules

2) Confidence 0.76 Published 2007 Journal Arch. Pathol. Lab. Med. Section Body Doc Link 17616998 Disease Relevance 0 Pain Relevance 0

Immunohistochemistry was used to evaluate p63 expression.

Gene_expression (expression) of p63

3) Confidence 0.76 Published 2007 Journal Arch. Pathol. Lab. Med. Section Body Doc Link 17616998 Disease Relevance 0 Pain Relevance 0

Compared to their non-disrupted counterparts, focally disrupted tumor capsules displayed a number of unique alterations, including a significantly lower proliferation index and p63 expression, but a significantly higher frequency of degeneration, apoptosis and infiltration of leukocytes, which are generally located at or near focally disrupted tumor capsules (Fig 3d). 3.

Gene_expression (expression) of p63 in leukocytes associated with cancer and apoptosis

4) Confidence 0.68 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2931352 Disease Relevance 1.24 Pain Relevance 0

Immunohistochemical analysis confirmed the urothelial histotype (positive for thrombomodulin, p63 and high-molecular-weight cytokeratins) and disclosed focal neuroendocrine differentiation.

Gene_expression (positive) of p63

5) Confidence 0.67 Published 2009 Journal Virchows Arch. Section Abstract Doc Link 19002493 Disease Relevance 0.80 Pain Relevance 0.13

Immunofluorescence revealed that most Rb-LSCs were positive for p63 (Figure 1B), integrinß1 (Figure 1C), and some of the cultured cells expressed cytokeratin 3 (Figure 1D,E).

Gene_expression (expressed) of p63

6) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2627808 Disease Relevance 0 Pain Relevance 0

Quantitative RT-PCR revealed that the expression of the positive putative LSC markers DeltaNp63 and ABCG2 also showed a steady decrease in the zones furthest from the explant (p < 0.05 and p < 0.005, respectively).

Gene_expression (expression) of DeltaNp63

7) Confidence 0.59 Published 2008 Journal Regenerative medicine Section Body Doc Link 18462056 Disease Relevance 0 Pain Relevance 0

In addition, the expression of DeltaNp63, ABCG2 (both putative positive LSC markers) and cytokeratin K3 (marker of corneal differentiation) were assessed using quantitative reverse transcription PCR (RT-PCR).

Gene_expression (expression) of DeltaNp63

8) Confidence 0.59 Published 2008 Journal Regenerative medicine Section Body Doc Link 18462056 Disease Relevance 0 Pain Relevance 0

Nevertheless, it remains unclear whether the lack of p63 expression in some lesions is related to the extent of the disease, to its clinical behavior, or to exacerbation of the accompanying symptoms.

Gene_expression (expression) of p63

9) Confidence 0.59 Published 2007 Journal Arch. Pathol. Lab. Med. Section Body Doc Link 17616998 Disease Relevance 0 Pain Relevance 0

CONCLUSIONS: Endometriotic lesions express p63 differently, and some retain the basal/reserve cell immunophenotype.

Gene_expression (express) of p63

10) Confidence 0.59 Published 2007 Journal Arch. Pathol. Lab. Med. Section Body Doc Link 17616998 Disease Relevance 0 Pain Relevance 0

One aim of this paper was to study the elimination of KET and its major metabolite norketamine (NKET) in urine collected from five nonhuman primates that received a single dose (5 mg/kg, I.M.) of KET and to study elimination patterns to determine how long after drug administration KET and NKET can be detected.

Gene_expression (detected) of KET in urine

11) Confidence 0.53 Published 2005 Journal J Anal Toxicol Section Abstract Doc Link 15842758 Disease Relevance 0 Pain Relevance 0.19

In one monkey, KET and its metabolites were detected in urine up to 4 days after drug administration, up to 7 days in two monkeys, up to 11 days in one monkey, and 16 days after KET injection in one monkey.

Gene_expression (detected) of KET in urine

12) Confidence 0.53 Published 2005 Journal J Anal Toxicol Section Abstract Doc Link 15842758 Disease Relevance 0 Pain Relevance 0.07

In two monkeys, KET was detected in urine up to 3 days after drug administration (32-7070 ng/mL); in one monkey, it was detected up to 4 days (65-13,500 ng/mL); in one monkey, it was detected only on days 1 and 2 (4000 and 70 ng/mL, respectively); and in one monkey, it was detected 10 days after KET injection (22-35,000 ng/mL).

Gene_expression (detected) of KET in urine

13) Confidence 0.53 Published 2005 Journal J Anal Toxicol Section Abstract Doc Link 15842758 Disease Relevance 0 Pain Relevance 0.16

The last aim of this study was to apply and evaluate a newly developed ELISA screening methodology for detection of KET and its metabolites in the same urine samples collected from primates which received a single dose of KET.

Gene_expression (detection) of KET in urine

14) Confidence 0.53 Published 2005 Journal J Anal Toxicol Section Abstract Doc Link 15842758 Disease Relevance 0 Pain Relevance 0.17

Promoted by the fact that the basal cell layer is the sole source of tumor suppressor p63 and maspin in prostate 31-33, and that the absence of the basal cell layers is one of the most distinct morphological signs of invasive cancers, our resent studies have attempted to identify the early signs of tumor capsule disruptions.

Gene_expression (source) of p63 in basal cell associated with cancer

15) Confidence 0.53 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2931352 Disease Relevance 1.12 Pain Relevance 0.08

Where cultures underwent stratification, the expression of p63 was observed in the basal layer.

Gene_expression (expression) of p63 in basal layer

16) Confidence 0.52 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.09 Pain Relevance 0

With respect to the subgroup of LMSs, there are several indications that LMS arising in the uterus is biologically different than LMS originating elsewhere.

Gene_expression (originating) of LMS in uterus associated with leiomyosarcoma

17) Confidence 0.50 Published 2009 Journal Sarcoma Section Body Doc Link PMC2801456 Disease Relevance 0.57 Pain Relevance 0

In all of these studies it is likely that cases of GIST were included in the LMS groups.

Gene_expression (groups) of LMS associated with gastrointestinal stromal tumor

18) Confidence 0.50 Published 2009 Journal Sarcoma Section Body Doc Link PMC2801456 Disease Relevance 0.65 Pain Relevance 0

EEC syndrome, Arg227Gln TP63 mutation and micturition difficulties: Is there a genotype-phenotype correlation?

Gene_expression (mutation) of TP63 (R227Q) associated with syndrome and overactive bladder

19) Confidence 0.49 Published 2007 Journal Am. J. Med. Genet. A Section Title Doc Link 17431922 Disease Relevance 1.09 Pain Relevance 0.07

Chromogranin, sinaptophysin, NSE, smooth muscle actin, p63, Her-2, oestrogen and progesterone receptors were negative, Mib1 (Ki67) and P53 were positive in less than 5% of the cells.

Neg (negative) Gene_expression (negative) of p63 in smooth muscle

20) Confidence 0.49 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1764883 Disease Relevance 0.34 Pain Relevance 0

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