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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.40
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PMEL) extracellular region (PMEL) Golgi apparatus (PMEL)
endoplasmic reticulum (PMEL) plasma membrane (PMEL)
Anatomy Link Frequency
melanocytes 1
PMEL (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 1 84.64 Quite High
melanocortin 1 receptor 1 73.28 Quite High
Cluster headache 2 50.00 Quite Low
Pain 21 44.44 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cluster Headache 2 84.20 Quite High
Influenza Virus Infection 2 76.24 Quite High
Trismus 2 68.88 Quite High
Cancer 44 62.56 Quite High
Skin Cancer 52 60.00 Quite High
Disease 27 50.00 Quite Low
Apoptosis 16 50.00 Quite Low
Toxicity 14 50.00 Quite Low
Mouth Cancer 11 46.96 Quite Low
Pain 19 44.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DESIGN AND METHODS: ELISA was used to determine the serum levels of soluble interleukin-2 receptors, interleukin-1, interleukin-6, and 2 soluble interleukin-6 receptors (sIL-6R and soluble gp130) in 18 patients with cluster headache (6 women and 12 men) during the cluster period and in 17 healthy controls who were headache-free (3 women and 14 men).
Spec (determine) Regulation (determine) of sIL
1) Confidence 0.44 Published 2003 Journal Headache Section Body Doc Link 12864761 Disease Relevance 0.08 Pain Relevance 0
A number of the experimental and epidemiological studies investigated the effect of changing snuff habits on the presence and severity of SIL.
Spec (investigated) Regulation (effect) of SIL
2) Confidence 0.39 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2390522 Disease Relevance 0 Pain Relevance 0.04
secreting CD8+ clones specific for gp100 and Melan A/MART-1 even before vaccination, and this high frequency did not change (gp100) or slightly decreased (Melan A/MART-1) after vaccination.
Neg (not) Regulation (change) of gp100
3) Confidence 0.11 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.25 Pain Relevance 0
The direct targets of Tfap2 in melanocytes are currently under investigation.

Regulation (targets) of melanocytes in melanocytes
4) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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