INT111892

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Context Info
Confidence 0.08
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.09
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2, Ptger1) signal transducer activity (Ptger2, Ptger1)
Anatomy Link Frequency
osteoblast 2
microglia 1
Ptger2 (Rattus norvegicus)
Ptger1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 13 93.68 High High
acular 8 93.48 High High
Inflammatory response 2 70.92 Quite High
agonist 16 54.80 Quite High
Inflammation 8 52.32 Quite High
metalloproteinase 5 14.16 Low Low
Catecholamine 2 11.44 Low Low
antagonist 12 5.20 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 10 97.92 Very High Very High Very High
INFLAMMATION 18 93.44 High High
Disease 13 90.84 High High
Apoptosis 4 84.96 Quite High
Toxicity 1 79.20 Quite High
Death 2 56.16 Quite High
Neurodegenerative Disease 2 48.04 Quite Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Dementia 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2 acts on four different receptors, EP1-EP4 [66], of which microglia express three, namely EP1, EP2, and EP3; the latter having been exclusively detected in activated microglia [67].
PGE2 Regulation (acts) of EP1 in microglia
1) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.77 Pain Relevance 0.18
The effects of prostaglandin E1 (PGE1) and PGE2 on TGF-beta expression and bioactivity were also examined in order to understand more about the role of prostaglandins in osteoblast function.
PGE2 Spec (examined) Regulation (effects) of prostaglandin E1 in osteoblast associated with osteoporosis
2) Confidence 0.01 Published 2003 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 12873036 Disease Relevance 0.66 Pain Relevance 0.68
The effects of prostaglandin E1 (PGE1) and PGE2 on TGF-beta expression and bioactivity were also examined in order to understand more about the role of prostaglandins in osteoblast function.
PGE2 Spec (examined) Regulation (effects) of PGE1 in osteoblast associated with osteoporosis
3) Confidence 0.01 Published 2003 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 12873036 Disease Relevance 0.66 Pain Relevance 0.68

General Comments

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