INT112016

Context Info Confidence 0.32 First Reported 2002 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 4.62 Pain Relevance 1.28

Anatomy Link Frequency urine 1 IgG2a (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 22 99.48 cINOD 7 95.76 chemokine 16 94.96 dexamethasone 5 92.88 methotrexate 5 92.48 cytokine 109 89.20 Inflammation 30 84.72 rheumatoid arthritis 46 82.32 transdermal 21 50.00 antagonist 14 36.96

Disease Link Frequency Relevance Heat Immunization 140 99.98 Renal Disease 31 99.88 Chlamydia Infection 67 99.80 Arthritis 29 99.48 Systemic Lupus Erythematosus 119 93.00 INFLAMMATION 38 92.92 Infection 35 90.88 Diabetes Mellitus 6 90.04 Apoptosis 6 89.48 Influenza Virus Infection 105 82.48

Sentences Mentioned In

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that in vivo administration of vitamin C by intraperitoneal injection affected isotype switching as previously reported: the titer of antigen-specific IgG1 antibody was decreased, while that of IgG2a was unaffected.

Neg (unaffected) Negative_regulation (unaffected) of IgG2a

1) Confidence 0.32 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998772 Disease Relevance 0.09 Pain Relevance 0

Administration of indomethacin resulted in suppression of antigen (OVA)-induced arthritis that was associated with inhibition of anti-OVA IgG2a but not IgG1 production.

Negative_regulation (inhibition) of IgG2a associated with arthritis

2) Confidence 0.28 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.38

Administrations of all the drugs used resulted in suppression of antigen (OVA)-induced arthritis in mice which was associated with inhibition of anti-OVA IgG2a but not IgG1 production.

Negative_regulation (inhibition) of IgG2a associated with arthritis

3) Confidence 0.26 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.61 Pain Relevance 0.57

We found that the IM-immunized groups on day 14 after immunization exhibited IgG1/IgG2a ratios of 2 and 0.3 with 3 µg and 10 µg inactivated virus, respectively (Figure 3B, D).

Negative_regulation (exhibited) of IgG2a associated with immunization

4) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.55 Pain Relevance 0

In contrast, the MN-immunized groups had IgG1/IgG2a ratios of 24 and 4 in the 3 µg and 10 µg groups, respectively.

Negative_regulation (had) of IgG2a

5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.56 Pain Relevance 0

B/WF1 mice monthly injected repeatedly with the IL-4p DNA intraperitoneally before and after the active phase drastically delayed the development of glomerulonephritis with deposits of IgG2a and C3 leading to excretion of urine protein, and they showed prolonged survival (Figure 4).

Negative_regulation (deposits) of IgG2a in urine associated with renal disease

6) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 1.04 Pain Relevance 0

Anticollagen IgG2a (regarded as a marker for a Th1 response) was reduced, and there was an increase in IgG1 (regarded as a marker for a Th2 response).

Negative_regulation (reduced) of IgG2a

7) Confidence 0.12 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.59 Pain Relevance 0.10

In this study, Chlamydia infection enhanced IgG2a Ab responses, which were reduced after CCL5 inhibition.

Negative_regulation (reduced) of IgG2a associated with chlamydia infection

8) Confidence 0.10 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.70 Pain Relevance 0.24

production after IM vaccination is consistent with the heightened Th1-like response indicated by the reduced IgG1/IgG2a ratio in the IM groups, since IFN-?

Negative_regulation (reduced) of IgG2a

9) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.16 Pain Relevance 0

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