INT112061

Context Info Confidence 0.01 First Reported 2003 Last Reported 2003 Negated 2 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.33 Pain Relevance 0.44

Anatomy Link Frequency brain 4 Kcnk2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Nucleus accumbens 4 84.84 Glutamate 2 81.40 dopamine receptor 2 78.96 gABA 2 75.00 Dopamine 2 75.00 Enkephalin 2 25.00

Disease Link Frequency Relevance Heat Schizophrenia 4 97.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results indicate that the neonatal VH lesion did not alter expression of D1R, D3R, neurotensin or proenkephalin expression in any brain region examined.

Neg (not) Regulation (alter) of Gene_expression (expression) of D1R in brain

1) Confidence 0.01 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.17 Pain Relevance 0.22

Antipsychotic drugs did not alter expression of D1R, D2R or D3R receptor mRNAs but elevated neurotensin and proenkephalin expression in both groups of rats; patterns of changes were dependent on the duration of treatment and brain area examined.

Neg (not) Regulation (alter) of Gene_expression (expression) of D1R in brain

2) Confidence 0.01 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.16 Pain Relevance 0.22

General Comments

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