INT112190

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 5.83
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
sciatic nerve 4
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 20 99.80 Very High Very High Very High
Antinociceptive 7 99.16 Very High Very High Very High
tolerance 13 99.12 Very High Very High Very High
Inflammation 37 98.76 Very High Very High Very High
addiction 8 98.56 Very High Very High Very High
Thermal hyperalgesia 37 98.36 Very High Very High Very High
Sciatic nerve 154 98.20 Very High Very High Very High
Inflammatory response 8 98.04 Very High Very High Very High
allodynia 62 97.20 Very High Very High Very High
Spinal cord 107 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 201 100.00 Very High Very High Very High
Shock 3 99.70 Very High Very High Very High
INFLAMMATION 46 98.76 Very High Very High Very High
Nervous System Injury 64 98.48 Very High Very High Very High
Hyperalgesia 39 98.36 Very High Very High Very High
Neuropathic Pain 110 97.20 Very High Very High Very High
Stress 11 96.32 Very High Very High Very High
Aging 1 91.60 High High
Inflammatory Pain 7 82.96 Quite High
Necrosis 1 75.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, targeted disruption of iNOS gene did not affect carrageenan-induced thermal hyperalgesia in either the early (2-6 h) or late phase.
Regulation (targeted) of Negative_regulation (disruption) of iNOS associated with targeted disruption and thermal hyperalgesia
1) Confidence 0.62 Published 2003 Journal Neuroscience Section Abstract Doc Link 12895524 Disease Relevance 0.81 Pain Relevance 0.65
The effect of aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, on morphine-induced tolerance and dependence in mice was investigated in this study.
Regulation (effect) of Negative_regulation (inhibitor) of inducible nitric oxide synthase associated with addiction, tolerance and morphine
2) Confidence 0.45 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16730698 Disease Relevance 0.07 Pain Relevance 0.91
The effect of aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, on morphine-induced tolerance and dependence in mice was investigated in this study.
Regulation (effect) of Negative_regulation (inhibitor) of iNOS associated with addiction, tolerance and morphine
3) Confidence 0.45 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16730698 Disease Relevance 0.07 Pain Relevance 0.91
This effect was due to down-regulation of iNOS mRNA and suppression of iNOS proteins, i.e., blueberry extract may inhibit one of the primary steps in the inflammatory stress pathway [41].
Regulation (regulation) of Negative_regulation (suppression) of iNOS associated with stress and inflammation
4) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693933 Disease Relevance 0.87 Pain Relevance 0.20
The data show that the inhibitory activities of alpha- and gamma-mangostins are not due to direct inhibition of iNOS enzyme activity.
Neg (not) Regulation (due) of Negative_regulation (inhibition) of iNOS
5) Confidence 0.38 Published 2008 Journal Food Chem. Toxicol. Section Abstract Doc Link 18029076 Disease Relevance 0.22 Pain Relevance 0.11
Taken together, our data indicate that the anti-inflammatory and antinociceptive properties of siegeskaurolic acid may be due to iNOS, COX-2 and TNF-alpha inhibition via the down-regulation of NF-kappaB binding activity.
Regulation (due) of Negative_regulation (inhibition) of iNOS associated with inflammation and antinociceptive
6) Confidence 0.33 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17207792 Disease Relevance 0.45 Pain Relevance 0.23
Therefore, we hypothesized that the unaltered changes in NOS1 expression observed in NOS2-KO mice and the genetic lack of NOS2 in these KO mice might explain the absence of mechanical and thermal allodynia as well as thermal hyperalgesia in their behavior responses after sciatic nerve ligation.
Spec (might) Regulation (changes) of Negative_regulation (lack) of NOS2 in sciatic nerve associated with targeted disruption, allodynia, thermal hyperalgesia and sciatic nerve
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.56 Pain Relevance 1.00
Therefore, we hypothesized that the unaltered changes in NOS1 expression observed in NOS2-KO mice and the genetic lack of NOS2 in these KO mice might explain the absence of mechanical and thermal allodynia as well as thermal hyperalgesia in their behavior responses after sciatic nerve ligation.
Spec (might) Regulation (unaltered) of Negative_regulation (lack) of NOS2 in sciatic nerve associated with targeted disruption, allodynia, thermal hyperalgesia and sciatic nerve
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.57 Pain Relevance 1.00
Studies of endotoxin induced shock indicate that iNOS inhibition has little or no beneficial effect in the presence of a failing eNOS system, because some nitric oxide is needed to maintain adequate organ function [97].
Neg (little) Regulation (effect) of Negative_regulation (inhibition) of iNOS associated with shock
9) Confidence 0.11 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.21 Pain Relevance 0.09

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