INT11238

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 44
Disease Relevance 39.70
Pain Relevance 9.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ADA) aging (ADA) cytoplasm (ADA)
cytosol (ADA) extracellular space (ADA) cell adhesion (ADA)
Anatomy Link Frequency
visceral 6
lymphocyte 5
immune system 4
CSF 3
immune cells 3
ADA (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 1688 100.00 Very High Very High Very High
adenocard 262 100.00 Very High Very High Very High
Infliximab 520 99.70 Very High Very High Very High
Central nervous system 9 99.16 Very High Very High Very High
headache 45 97.12 Very High Very High Very High
Hyperalgesia 1 95.76 Very High Very High Very High
Angina 22 93.64 High High
Inflammation 115 91.80 High High
corticosteroid 160 90.88 High High
methotrexate 58 89.00 High High
Disease Link Frequency Relevance Heat
Pleural Effusion 27 100.00 Very High Very High Very High
Latent Tuberculosis 24 99.98 Very High Very High Very High
Fever 729 99.92 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 62 99.84 Very High Very High Very High
Listeria Meningitis 24 99.74 Very High Very High Very High
Central Nervous System Disease 1 99.52 Very High Very High Very High
Leukocytosis 10 99.28 Very High Very High Very High
Communicable Diseases 48 99.12 Very High Very High Very High
Disease 929 99.08 Very High Very High Very High
Severe Combined Immunodeficiency 24 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The adenosine deaminase (ADA) level in the pleural effusion was elevated.
Positive_regulation (elevated) of ADA associated with pleural effusion and adenocard
1) Confidence 0.70 Published 2005 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 15997786 Disease Relevance 1.43 Pain Relevance 0.18
The adenosine deaminase (ADA) level in the pleural effusion was elevated.
Positive_regulation (elevated) of adenosine deaminase associated with pleural effusion and adenocard
2) Confidence 0.70 Published 2005 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 15997786 Disease Relevance 1.44 Pain Relevance 0.18
Pleural effusion was characterized as exudative lymphocyte-predominant fluid with elevation of adenosine deaminase (ADA).
Positive_regulation (elevation) of adenosine deaminase in lymphocyte associated with pleural effusion and adenocard
3) Confidence 0.68 Published 1994 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 8114380 Disease Relevance 0.52 Pain Relevance 0.14
Pleural effusion was characterized as exudative lymphocyte-predominant fluid with elevation of adenosine deaminase (ADA).
Positive_regulation (elevation) of ADA in lymphocyte associated with pleural effusion and adenocard
4) Confidence 0.68 Published 1994 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 8114380 Disease Relevance 0.52 Pain Relevance 0.14
Increased serum/plasma ADA activity, comprising both ADA-1 and ADA-2 activity, has been used as a biochemical marker for infectious diseases.22–24 Increased serum ADA has been reported in infectious diseases such as viral and bacterial pneumonia, HIV infection, extra-pulmonary and pulmonary tuberculosis, visceral leishmaniasis, and mononucleosis.21,22,25
Positive_regulation (Increased) of ADA in visceral associated with leishmaniasis, mycobacterial infection, bacterial pneumonia, acquired immune deficiency syndrome or hiv infection, communicable diseases and infection
5) Confidence 0.65 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.40 Pain Relevance 0.11
A final question that requires more attention is the appropriate induction doses for ADA (160 mg/80 mg or 80 mg/40 mg).
Positive_regulation (induction) of ADA associated with adalimumab
6) Confidence 0.59 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.18 Pain Relevance 0.34
An increased serum level of ADA has been reported in infectious diseases such as HIV infection, tuberculosis, and visceral leishmaniasis.22,25,39 However, the present study is the first to describe increased serum ADA and XO in CCHF patients.
Positive_regulation (increased) of ADA in visceral associated with leishmaniasis, mycobacterial infection, acquired immune deficiency syndrome or hiv infection, communicable diseases, fever and infection
7) Confidence 0.57 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.72 Pain Relevance 0
An increased serum level of ADA has been reported in infectious diseases such as HIV infection, tuberculosis, and visceral leishmaniasis.22,25,39 However, the present study is the first to describe increased serum ADA and XO in CCHF patients.
Positive_regulation (increased) of serum ADA in visceral associated with leishmaniasis, mycobacterial infection, acquired immune deficiency syndrome or hiv infection, communicable diseases, fever and infection
8) Confidence 0.57 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.75 Pain Relevance 0
The pleural fluid revealed an increased adenosine deaminase concentration and cultures were negative for mycobacteria.
Positive_regulation (increased) of adenosine deaminase in pleural fluid associated with adenocard
9) Confidence 0.53 Published 2006 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 16629497 Disease Relevance 1.22 Pain Relevance 0.21
Children born with a life-threatening immune system disorder, severe combined immune deficiency (SCID), were cured after receiving gene therapy for replacement of their defective adenosine deaminase (ADA) gene.
Positive_regulation (defective) of ADA in immune system associated with adenocard and severe combined immunodeficiency
10) Confidence 0.49 Published 2003 Journal Expert Opin Biol Ther Section Abstract Doc Link 12718732 Disease Relevance 0.23 Pain Relevance 0.05
Children born with a life-threatening immune system disorder, severe combined immune deficiency (SCID), were cured after receiving gene therapy for replacement of their defective adenosine deaminase (ADA) gene.
Positive_regulation (replacement) of ADA in immune system associated with adenocard and severe combined immunodeficiency
11) Confidence 0.49 Published 2003 Journal Expert Opin Biol Ther Section Abstract Doc Link 12718732 Disease Relevance 0.23 Pain Relevance 0.05
In CD, data from CLASSIC I reported that only 1 patient of 225 (0.04%) in the ADA 160 mg/80 mg group had a positive assay at week 2 with a subsequent negative assay at week 4 (Hanauer et al 2006); in GAIN, none of the 159 patients treated with ADA had positive results for anti-ADA antibodies at week 4 (Sandborn et al 2007a).
Positive_regulation (results) of anti-ADA associated with adalimumab and disease
12) Confidence 0.49 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.43 Pain Relevance 0.60
In conclusion, we showed that ADA and XO levels were increased in patients with CCHF.
Positive_regulation (increased) of ADA associated with fever
13) Confidence 0.44 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.06 Pain Relevance 0.10
Chittiprol and co-workers found high levels of plasma ADA in HIV-infected patients compared with controls, and this high level of ADA was associated with lymphocyte and monocyte infection by HIV.
Positive_regulation (level) of ADA in monocyte associated with acquired immune deficiency syndrome or hiv infection and infection
14) Confidence 0.44 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.72 Pain Relevance 0
Adenosine deaminase and xanthine oxidase levels were increased in patients with Crimean–Congo hemorrhagic fever.
Positive_regulation (increased) of Adenosine deaminase associated with adenocard and fever
15) Confidence 0.44 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2910858 Disease Relevance 0.91 Pain Relevance 0.33
Increased serum/plasma ADA activity, comprising both ADA-1 and ADA-2 activity, has been used as a biochemical marker for infectious diseases.22–24 Increased serum ADA has been reported in infectious diseases such as viral and bacterial pneumonia, HIV infection, extra-pulmonary and pulmonary tuberculosis, visceral leishmaniasis, and mononucleosis.21,22,25
Positive_regulation (Increased) of ADA in visceral associated with leishmaniasis, mycobacterial infection, bacterial pneumonia, acquired immune deficiency syndrome or hiv infection, communicable diseases and infection
16) Confidence 0.44 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.51 Pain Relevance 0.11
Increased serum/plasma ADA activity, comprising both ADA-1 and ADA-2 activity, has been used as a biochemical marker for infectious diseases.22–24 Increased serum ADA has been reported in infectious diseases such as viral and bacterial pneumonia, HIV infection, extra-pulmonary and pulmonary tuberculosis, visceral leishmaniasis, and mononucleosis.21,22,25
Positive_regulation (Increased) of ADA in visceral associated with leishmaniasis, mycobacterial infection, bacterial pneumonia, acquired immune deficiency syndrome or hiv infection, communicable diseases and infection
17) Confidence 0.44 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.51 Pain Relevance 0.11
Children born with a life-threatening immune system disorder, severe combined immune deficiency (SCID), were cured after receiving gene therapy for replacement of their defective adenosine deaminase (ADA) gene.
Positive_regulation (defective) of deaminase in immune system associated with adenocard and severe combined immunodeficiency
18) Confidence 0.43 Published 2003 Journal Expert Opin Biol Ther Section Abstract Doc Link 12718732 Disease Relevance 0.23 Pain Relevance 0.05
Children born with a life-threatening immune system disorder, severe combined immune deficiency (SCID), were cured after receiving gene therapy for replacement of their defective adenosine deaminase (ADA) gene.
Positive_regulation (replacement) of deaminase in immune system associated with adenocard and severe combined immunodeficiency
19) Confidence 0.43 Published 2003 Journal Expert Opin Biol Ther Section Abstract Doc Link 12718732 Disease Relevance 0.23 Pain Relevance 0.05
Although certain details about the optimal way to use ADA for the management of CD exist, undoubtedly this subcutaneously administered anti-TNF medication will play a crucial role in treating patients with CD (Bressler 2007).



Positive_regulation (use) of ADA associated with adalimumab and disease
20) Confidence 0.42 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.35 Pain Relevance 0.38

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