INT112386

Context Info Confidence 0.47 First Reported 2003 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.72 Pain Relevance 0.77

signal transduction (IL1RL1) extracellular space (IL1RL1) extracellular region (IL1RL1) plasma membrane (IL1RL1) intracellular (IL1RL1)

Anatomy Link Frequency central area 2 IL1RL1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 2 100.00 antagonist 1 100.00 rheumatoid arthritis 5 97.04 imagery 19 88.88 Inflammation 3 88.16 Migraine 3 65.24 depression 11 50.00 Action potential 5 5.00 medulla 4 5.00 Pain 4 5.00

Disease Link Frequency Relevance Heat Cancer 7 100.00 INFLAMMATION 5 100.00 Disease 4 100.00 Necrosis 1 100.00 Rheumatoid Arthritis 5 97.04 Foreign Bodies 49 93.60 Soft Tissue Neoplasm 4 92.80 Cognitive Disorder 3 88.60 Hematoma 4 77.44 Foreign-body Granuloma 16 68.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The current therapeutic model encourages a step-up approach that safely incorporates several currently available classes of agents: non-steroidal anti-inflammatory drugs, selective cyclo-oxygenase-2 inhibitors, glucocorticoids, disease-modifying anti-rheumatic drugs, and biological agents (tumour necrosis factor-alpha inhibitors and interleukin-1 receptor antagonist).

Positive_regulation (incorporates) of Gene_expression (antagonist) of interleukin-1 receptor associated with necrosis, inflammation, cancer, antagonist, cinod and disease

1) Confidence 0.47 Published 2003 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 12915159 Disease Relevance 1.19 Pain Relevance 0.51

The twitches, be it T1 or T4, were calculated identically using the calculated peak value of [ARA] after the first or the fourth stimulus:

Positive_regulation (calculated) of Gene_expression (be) of T1

2) Confidence 0.25 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0 Pain Relevance 0

The central area of the reactive lesion is observed as low intensities on T1- and high intensities on T2-weighted images with no enhancement, which suggests that the lesion is myxomatous or cystic (8,9).

Positive_regulation (intensities) of Gene_expression (intensities) of T1 in central area

3) Confidence 0.24 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852748 Disease Relevance 1.16 Pain Relevance 0.20

There are differences between the data presented in this paper and that obtained by SS stimulation:

Positive_regulation (by) of Gene_expression (obtained) of stimulation

4) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0.37 Pain Relevance 0.07

General Comments

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