INT112458

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Context Info
Confidence 0.04
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.10
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Selenbp2) nucleus (Selenbp2) cytoplasm (Selenbp2)
Anatomy Link Frequency
blood 1
Selenbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 44 100.00 Very High Very High Very High
cINOD 13 98.48 Very High Very High Very High
aspirin 6 92.80 High High
Pain 137 86.56 High High
Codeine 5 86.36 High High
Bile 3 85.84 High High
Opioid 74 85.32 High High
Cancer pain 44 83.72 Quite High
Inflammation 6 81.36 Quite High
Analgesic 44 81.28 Quite High
Disease Link Frequency Relevance Heat
Renal Insufficiency 4 97.24 Very High Very High Very High
Toxicity 4 95.36 Very High Very High Very High
Hepatotoxicity 3 93.96 High High
Pain 158 86.56 High High
Cancer Pain 53 83.72 Quite High
INFLAMMATION 7 81.36 Quite High
Inflammatory Pain 1 68.88 Quite High
Myocardial Infarction 4 57.68 Quite High
Disease 9 49.12 Quite Low
Cancer 61 48.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There were some differences at pH levels of 1.2 and 6.8 in the release of acetaminophen from the physical mixture compared to the matrix particles.
Localization (release) of acetaminophen associated with paracetamol
1) Confidence 0.04 Published 2005 Journal Chem. Pharm. Bull. Section Abstract Doc Link 15635226 Disease Relevance 0 Pain Relevance 1.21
The 70% release time, T70, of acetaminophen from the matrix particles (Act : Cht=1 : 5) increased in pH 1.2 fluid by about 9-fold and in pH 6.8 fluid by about 5-fold compared to crystalline acetaminophen.
Localization (release) of acetaminophen associated with paracetamol
2) Confidence 0.04 Published 2005 Journal Chem. Pharm. Bull. Section Abstract Doc Link 15635226 Disease Relevance 0 Pain Relevance 1.09
Acetaminophen is excreted by kidneys and dosing must be adjusted in patients with significant renal insufficiency.
Localization (excreted) of Acetaminophen associated with paracetamol and renal insufficiency
3) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 1.10 Pain Relevance 2.22
Treatment with the microsomal enzyme inducer trans-stilbene oxide (TSO) can decrease biliary excretion of acetaminophen-glucuronide (AA-GLUC) and increase efflux of AA-GLUC into blood.
Localization (excretion) of acetaminophen-glucuronide in blood associated with paracetamol
4) Confidence 0.00 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12920174 Disease Relevance 0 Pain Relevance 0.22

General Comments

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