INT112563

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 14
Disease Relevance 3.82
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (PSMG1) cytoplasm (PSMG1)
Anatomy Link Frequency
platelets 9
PSMG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 24 97.52 Very High Very High Very High
aspirin 48 82.96 Quite High
agonist 25 79.04 Quite High
anesthesia 2 50.00 Quite Low
antagonist 1 50.00 Quite Low
adenocard 24 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 240 100.00 Very High Very High Very High
Cv General 3 Under Development 24 97.52 Very High Very High Very High
Thrombosis 48 85.48 High High
Coronary Artery Disease 48 67.36 Quite High
Coagulation Disorder 12 5.00 Very Low Very Low Very Low
Death 12 5.00 Very Low Very Low Very Low
Myocardial Infarction 12 5.00 Very Low Very Low Very Low
Hemorrhage 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured various platelet activation markers including expressions of PAC-1 and P-selectin, annexin V binding, and microparticle formations by means of whole-blood flow cytometry.
Gene_expression (expressions) of PAC-1 in platelet
1) Confidence 0.55 Published 2003 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 12928640 Disease Relevance 0 Pain Relevance 0
RESULTS: AA, ADP, and TRAP-6 markedly increased the expression of CD62P on platelets, whereas CD42b (shedding) and PAC-1 (heterotypic conjugates) expression decreased.
Gene_expression (expression) of PAC-1 in platelets
2) Confidence 0.47 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18499605 Disease Relevance 0 Pain Relevance 0
CD62P expression and PAC-1 binding appeared equally useful as indicators of the effects of anti-platelet treatment.
Gene_expression (expression) of PAC-1 in platelet associated with heart rate under development
3) Confidence 0.18 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.24 Pain Relevance 0.07
As expected, the median values of CD62P expression and PAC-1 binding in patients were significantly lower than in controls only in high responders (p < 0.0001) and intermediate responders (p < 0.0001 and p < 0.02, respectively).


Gene_expression (expression) of PAC-1 associated with heart rate under development
4) Confidence 0.15 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.37 Pain Relevance 0
Among the patients, six (11.5%) exhibited both CD62P expression and PAC-1 binding above the 1st quartile of normal (median and IQR: 29.5%, 23.4–42.9%; and 4.4%, 2.3–7.9%, respectively).
Gene_expression (expression) of PAC-1 associated with heart rate under development
5) Confidence 0.14 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.27 Pain Relevance 0
The median percentages of platelets exhibiting CD62P expression and PAC-1 binding in controls aged >30 years (54 ± 12.4, mean ± SD) or <30 years (27 ± 2, mean ± SD) were 24% vs. 23.6% and 4.8% vs. 2.1%, respectively, and were not significantly different.
Gene_expression (expression) of PAC-1 in platelets associated with heart rate under development
6) Confidence 0.14 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.41 Pain Relevance 0
A patient was defined as a "Low-responder" to clopidogrel when the percentages of platelets exhibiting CD62P expression and PAC-1 binding were both above the 1st quartile of normal distribution (21.4% and 1.7%, respectively); and as a "High-responder" when both values were below the 1st quartile of normal.
Gene_expression (expression) of PAC-1 in platelets associated with heart rate under development
7) Confidence 0.14 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.43 Pain Relevance 0
In contrast, 23 patients (44.2%) exhibited both CD62P expression and PAC-1 binding below the 1st quartile of normal (median and IQR: 7.8%, 1.8–19.7%; and 0.8%, 0.1–1.7%, respectively) and were defined as high-responders to clopidogrel.
Gene_expression (expression) of PAC-1 associated with heart rate under development
8) Confidence 0.14 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.34 Pain Relevance 0
Finally, a good correlation was found between % inhibition and the percentages of platelets that expressed CD62P or bound PAC-1 (Spearman r = -0.67, p < 0.0001; and -0.49, p < 0.002, respectively; Figure 2).


Gene_expression (expressed) of PAC-1 in platelets associated with heart rate under development
9) Confidence 0.14 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.26 Pain Relevance 0
By flow cytometric analysis, the percentages of platelets that expressed CD62P or bound PAC-1 (median and IQR) were 11.9% (1.8–43%) and 1.8% (0.1–8%) respectively, both significantly lower (p < 0.0002 and p < 0.007, respectively) than the corresponding values in normal controls.
Gene_expression (expressed) of PAC-1 in platelets associated with heart rate under development
10) Confidence 0.14 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.24 Pain Relevance 0
The median percentage of platelets exhibiting CD62P expression and PAC-1 binding by FC evaluation after stimulation in the presence of PG E1 was 25.4% (IQR: 21.4–33.1%) and 3.5% (1.7–9.4%), respectively.
Gene_expression (expression) of PAC-1 in platelets associated with heart rate under development
11) Confidence 0.14 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2683811 Disease Relevance 0.33 Pain Relevance 0.11
CD62P expression and PAC-1 binding showed no correlation with age (Spearman r = 0.17 and 0.16, respectively).
Gene_expression (expression) of PAC-1 associated with heart rate under development
12) Confidence 0.14 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.35 Pain Relevance 0
All six patients (11.5%) defined as low-responders on the basis of CD62P expression and PAC-1 binding were lower or equal to 15% inhibition, and all 23 patients (44.2%) defined as high-responders were above 15% inhibition (Figure 2 and 3).
Gene_expression (expression) of PAC-1 associated with heart rate under development
13) Confidence 0.12 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.22 Pain Relevance 0
We studied LR in patients with stable angina undergoing elective PCI, all on DAT for at least 7 days, by comparing: 1) Flow cytometry (FC) to measure platelet membrane expression of P-selectin (CD62P) and PAC-1 binding following double stimulation with ADP and collagen type I either in the presence of prostaglandin (PG) E1; 2) VerifyNow-P2Y12 test, in which results are reported as absolute P2Y12-Reaction-Units (PRU) or % of inhibition (% inhibition).


Gene_expression (expression) of PAC-1 in platelet associated with heart rate under development and angina
14) Confidence 0.12 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2683811 Disease Relevance 0.35 Pain Relevance 0.14

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