INT112667

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.72
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
smooth muscle 1
platelet 1
extracellular matrix 1
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 16 99.82 Very High Very High Very High
fibrosis 9 99.28 Very High Very High Very High
antagonist 6 98.90 Very High Very High Very High
Inflammation 13 97.36 Very High Very High Very High
addiction 2 89.96 High High
nMDA receptor 2 89.44 High High
agonist 4 84.92 Quite High
Chronic pancreatitis 6 84.64 Quite High
cINOD 4 83.20 Quite High
IPN 2 78.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 3 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Fracture Healing 12 99.70 Very High Very High Very High
Fibrosis 9 99.28 Very High Very High Very High
INFLAMMATION 8 97.36 Very High Very High Very High
Tibia Fractures 2 87.76 High High
Ankylosis 1 79.36 Quite High
Inflammatory Pain 2 78.72 Quite High
Pancreatitis 6 75.00 Quite High
Arthropathy 1 34.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results point to the negative effect of naproxen sodium on fracture healing is due to its decreasing effect on the level of TGF-beta1, which may be a new possible mechanism.
Negative_regulation (decreasing) of TGF-beta1 associated with fracture healing
1) Confidence 0.58 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.44 Pain Relevance 0.06
In combination treatment, ACBD prevented morphine-induced reduction of flow rate, total protein, calcium, and TGF-beta1 and reached control levels.
Negative_regulation (reduction) of TGF-beta1 associated with morphine
2) Confidence 0.53 Published 2006 Journal Acta. Biol. Hung. Section Abstract Doc Link 17048692 Disease Relevance 0 Pain Relevance 0.85
At the end of the first week, TGF-beta1 levels were significantly lower in naproxen-treated rats than those of the other groups excluding control (p = 0.002).
Negative_regulation (lower) of TGF-beta1
3) Confidence 0.42 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.61 Pain Relevance 0.23
Intraperitoneal injection of morphine (6 mg/kg) induced significant inhibition of salivary flow rate, total protein, calcium, and TGF-beta1 concentrations.
Negative_regulation (inhibition) of TGF-beta1 associated with morphine
4) Confidence 0.38 Published 2006 Journal Acta. Biol. Hung. Section Abstract Doc Link 17048692 Disease Relevance 0 Pain Relevance 0.79
This correcting effect of Ank was blocked by probenecid, a general inhibitor of organic anion transport [10], which was also shown to inhibit transforming growth factor-beta-1 (TGF-?
Negative_regulation (inhibit) of transforming growth factor-beta-1
5) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.08 Pain Relevance 0
Angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists attenuate fibrosis in the kidney, heart, and liver by suppressing transforming growth factor-beta1 mRNA and decreasing production of extracellular matrix proteins.
Negative_regulation (suppressing) of transforming growth factor-beta1 in extracellular matrix associated with fibrosis and antagonist
6) Confidence 0.19 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12944495 Disease Relevance 0.60 Pain Relevance 0.46
The mRNA amount of procollagen alpha2(I), alpha-smooth muscle actin (alpha-SMA), tissue inhibitor of metalloproteinase (TIMP)-1, and TGF-beta1 was also increased by PDGF-BB.
Negative_regulation (inhibitor) of TGF-beta1 in smooth muscle
7) Confidence 0.13 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0
This effect may be related to suppression of tumor necrosis factor-alpha, platelet-derived growth factor-receptor beta, and transforming growth factor-beta1 mRNA.
Negative_regulation (suppression) of transforming growth factor-beta1 mRNA in platelet associated with necrosis and cancer
8) Confidence 0.09 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15608084 Disease Relevance 0.84 Pain Relevance 0.43
During CIP, serum TGF-beta1 and protein expression of the TGF-beta receptor activin receptor-like kinase-5 (ALK5) were reduced.
Negative_regulation (reduced) of TGF-beta1
9) Confidence 0.05 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.15 Pain Relevance 0.15

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