INT11273

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Context Info
Confidence 0.20
First Reported 1992
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.71
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Gtf2i) nucleus (Gtf2i) embryo development (Gtf2i)
DNA binding (Gtf2i) molecular_function (Gtf2i) cellular_component (Gtf2i)
Anatomy Link Frequency
spinal cord 2
neurons 1
brainstem 1
Gtf2i (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 3 99.82 Very High Very High Very High
Spinal cord 6 98.52 Very High Very High Very High
Inflammation 12 91.60 High High
Thermal hyperalgesia 2 84.88 Quite High
withdrawal 1 81.36 Quite High
Hyperalgesia 4 77.68 Quite High
Dorsal horn neuron 1 75.00 Quite High
Antinociceptive 1 63.76 Quite High
Neuronal nitric oxide synthase 1 50.00 Quite Low
anesthesia 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 91.60 High High
Hyperalgesia 6 84.88 Quite High
Jaundice 2 69.28 Quite High
Pain 2 43.76 Quite Low
Hyperbilirubinemia 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three hours after i.pl. injection of carrageenan, the number of c-Fos-like immunoreactive (c-Fos-LI) neurons was significantly increased in laminae I-II, III-IV and V-VI of the ipsilateral spinal cord at L4-5 with the higher density in laminae I-II and V-VI.
Positive_regulation (increased) of I-II in spinal cord associated with spinal cord
1) Confidence 0.20 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12133574 Disease Relevance 0.32 Pain Relevance 0.53
At 6 h, there was complete protection against decreased amplitudes of BAEP waves II and III and increased I-II and I-III interwave intervals (brainstem conduction times corresponding to I-III and I-V in humans) with 50 mg/kg minocycline, and partial protection with lower doses.
Spec (partial) Positive_regulation (increased) of I-II in brainstem
2) Confidence 0.17 Published 2007 Journal Neonatology Section Body Doc Link 17556840 Disease Relevance 0.07 Pain Relevance 0
NADPH-diaphorase staining was significantly increased in laminae I-II in lumbar spinal cord 1 day after surgery but not after 6 to 7 days.
Neg (not) Positive_regulation (increased) of I-II in spinal cord
3) Confidence 0.00 Published 2003 Journal Anesthesiology Section Body Doc Link 12502994 Disease Relevance 0 Pain Relevance 0
Dorsal horn laminae I-II, V-VI and VII showed a greater than 200% increase in preproenkephalin mRNA-labeled neurons on the inflamed side as compared to the contralateral control.
Positive_regulation (increase) of I-II in neurons associated with dorsal horn
4) Confidence 0.00 Published 1992 Journal Neuroscience Section Abstract Doc Link 1545910 Disease Relevance 0.32 Pain Relevance 0.38

General Comments

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