INT11276

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Context Info
Confidence 0.00
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.94
Pain Relevance 6.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
neurons 3
retinas 1
medulla 1
spinal cord 1
astrocytes 1
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 58 100.00 Very High Very High Very High
Inflammation 18 100.00 Very High Very High Very High
gABA 8 100.00 Very High Very High Very High
Dorsal horn neuron 7 100.00 Very High Very High Very High
Endogenous opioid 3 100.00 Very High Very High Very High
spinal dorsal horn 12 99.68 Very High Very High Very High
agonist 5 99.68 Very High Very High Very High
Antinociceptive 2 99.50 Very High Very High Very High
Nicotine 14 99.04 Very High Very High Very High
Serotonin 2 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Aids-related Complex 131 96.60 Very High Very High Very High
Nociception 47 95.92 Very High Very High Very High
Generalized Anxiety Disorder 7 95.60 Very High Very High Very High
Hyperalgesia 5 90.96 High High
Inflammatory Pain 7 77.04 Quite High
Ganglion Cysts 2 73.88 Quite High
Targeted Disruption 36 70.48 Quite High
Arthritis 1 69.92 Quite High
Increased Venous Pressure Under Development 1 69.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mENK-IR neurons localized in middle and caudal parts of rectal INR amounted to one third of the total CTb-IR neurons, and mainly projected into the rostral and caudal rectum.
Localization (localized) of mENK in caudal parts
1) Confidence 0.00 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8912257 Disease Relevance 0 Pain Relevance 0.06
These results suggest that nicotine has an antinociceptive effect by promoting the release of Met-ENK, but not dynorphins and endorphins, from activated opioidergic neurons in spinal cord.
Localization (release) of Met-ENK in neurons associated with nicotine, antinociceptive and spinal cord
2) Confidence 0.70 Published 2008 Journal Brain Res. Section Abstract Doc Link 18048009 Disease Relevance 0.07 Pain Relevance 1.16
These observations indicate that 5-HT(3A) receptor co-localizes with GABA and ENK in the SDH, suggesting that serotonin may activate GABAergic and ENKergic neurons via 5-HT(3A) receptor subunit and therefore affect the release of GABA and ENK.
Localization (release) of ENK in neurons associated with gaba, gabaergic, spinal dorsal horn and serotonin
3) Confidence 0.69 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18586398 Disease Relevance 0.29 Pain Relevance 0.60
Co-localization of proenkephalin mRNA using cRNA probes and a cell-type-specific immunocytochemical marker for intact astrocytes in vitro.
Localization (Co-localization) of proenkephalin mRNA in astrocytes associated with enkephalin
4) Confidence 0.67 Published 1991 Journal J. Neurosci. Methods Section Title Doc Link 1712058 Disease Relevance 0 Pain Relevance 0.19
These observations indicate that 5-HT(3A) receptor co-localizes with GABA and ENK in the SDH, suggesting that serotonin may activate GABAergic and ENKergic neurons via 5-HT(3A) receptor subunit and therefore affect the release of GABA and ENK.
Localization (co-localizes) of ENK in SDH associated with gaba, gabaergic, spinal dorsal horn and serotonin
5) Confidence 0.64 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18586398 Disease Relevance 0.43 Pain Relevance 0.67
In situ hybridization on bovine and ovine adrenal sections revealed that ProEnkA mRNA was localized selectively in cells at the outer margin of the medulla, a region rich in adrenaline-containing cells.
Localization (localized) of ProEnkA mRNA in medulla associated with medulla
6) Confidence 0.62 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3587746 Disease Relevance 0 Pain Relevance 0.09
Preproenkephalin mRNA is the precursor of both Met- and Leu-enkephalin, which are both expressed by neurons in the spinal cord and mainly exert their effect on the ?
Localization (precursor) of Preproenkephalin mRNA in spinal cord associated with enkephalin and spinal cord
7) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.67 Pain Relevance 0.87
After this, the sections were thoroughly rinsed in PBS and incubated in the biotinylated secondary antibody solution for ENK (antimouse IgG made in horse, 1?
Localization (antimouse) of ENK associated with enkephalin
8) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.72
Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins.
Localization (localized) of Preproenkephalin mRNA in neurons associated with inflammation, enkephalin and dorsal horn neuron
9) Confidence 0.24 Published 1992 Journal Neuroscience Section Title Doc Link 1545910 Disease Relevance 0.33 Pain Relevance 0.55
The anti-nociceptive effects of PAR(1) agonist were mediated by endogenous opioids, as this effect was inhibited by local injection of naloxone methiodide, and because intraplantar injection of PAR(1) agonist increased mRNA expression of the endogenous opioid precursor proenkephalin.
Localization (expression) of opioid precursor proenkephalin associated with nociception, narcan, endogenous opioid and agonist
10) Confidence 0.08 Published 2009 Journal Pain Section Abstract Doc Link 19674841 Disease Relevance 1.14 Pain Relevance 1.28
In the present study, we determined the localization of cells expressing preproenkephalin (PPE) mRNA, which encodes the precursor of enkephalin peptides, in adult as well as in embryonic chicken retinas.
Spec (determined) Localization (localization) of preproenkephalin in retinas associated with enkephalin
11) Confidence 0.07 Published 1995 Journal Vis. Neurosci. Section Abstract Doc Link 7718499 Disease Relevance 0 Pain Relevance 0.43

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