INT112782

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.87
Pain Relevance 3.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
brain 1
nucleus 1
PDL 1
brainstem 1
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 200 99.62 Very High Very High Very High
nociceptor 13 99.62 Very High Very High Very High
Nicotine 146 99.40 Very High Very High Very High
medulla 12 98.52 Very High Very High Very High
Central nervous system 39 97.92 Very High Very High Very High
Spinal cord 127 92.84 High High
Lasting pain 62 92.40 High High
Hippocampus 101 87.32 High High
spinal dorsal horn 2 77.48 Quite High
Central grey 1 76.92 Quite High
Disease Link Frequency Relevance Heat
Pain 271 97.44 Very High Very High Very High
Nociception 70 87.76 High High
Stress 22 85.92 High High
Urological Neuroanatomy 4 84.24 Quite High
Hypersensitivity 7 68.60 Quite High
Hyperalgesia 31 63.00 Quite High
Cognitive Disorder 17 45.68 Quite Low
INFLAMMATION 19 40.12 Quite Low
Injury 14 38.76 Quite Low
Toxicity 4 36.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical localization of extracellular signal-regulated kinases 1 and 2 phosphorylated neurons in the brainstem of rat following visceral noxious stimulation.
Localization (localization) of extracellular signal-regulated kinases 1 in brainstem associated with medulla and nociceptor
1) Confidence 0.78 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12951195 Disease Relevance 0.15 Pain Relevance 0.64
The dose-dependent ropivacaine-induced phosphorylation of PKC and p44/42 MAPK and the membrane translocation of Rho kinase were also detected using Western blotting.
Localization (translocation) of p44
2) Confidence 0.73 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
In spite of this global diffusion, regional differences in the relative abundance of ERK1 and ERK2 have also been described by previous reports [45,47].
Localization (abundance) of ERK1
3) Confidence 0.62 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.31 Pain Relevance 0.77
Oritz and his colleagues found that, while ERK immunoreactivity was widely distributed in the rat brain, the relative abundance of ERK1 and ERK2 differed by close to 10-fold among the regions studied.
Localization (abundance) of ERK1 in brain
4) Confidence 0.62 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.30 Pain Relevance 0.76
Once activated by wide variety of extracellular signals through dual phosphorylation at threonine (Thr202) and tyrosine (Tyr204) sites [30], p-ERK proteins translocate from the cytoplasm into the nucleus and activate transcription factors such as CREB.
Localization (translocate) of p-ERK in nucleus
5) Confidence 0.54 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.42 Pain Relevance 0.52
Under normal state, the relative abundance of constitutive ERK1 and ERK2 differs greatly among specific regions in the rat CNS, while under pain state, both ERK1 and ERK2 can be effectively phosphorylated with a long-term duration by both transient and persistent pain, but with their response patterns being different from each other across distinct regions as well.
Localization (abundance) of ERK1 associated with pain, lasting pain and central nervous system
6) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.70 Pain Relevance 0.65
In nerve fibers of the PDL, p-ERK1/2 was colocalized with PGP 9.5, CGRP, and calretinin.
Localization (colocalized) of p-ERK1 in PDL
7) Confidence 0.15 Published 2009 Journal J. Periodontol. Section Body Doc Link 19405839 Disease Relevance 0 Pain Relevance 0
These observations have been confirmed further by co-localization of p-ERK1/2 within the cytosol by immunoflorescence study.
Localization (localization) of p-ERK1
8) Confidence 0.05 Published 2008 Journal Tob Induc Dis Section Body Doc Link PMC2556029 Disease Relevance 0 Pain Relevance 0.19
Cytoplasmic localization of activated p-ERK1/2 by H2O2 and nicotine as determined by immunofluorescence
Localization (localization) of p-ERK1 associated with nicotine
9) Confidence 0.04 Published 2008 Journal Tob Induc Dis Section Body Doc Link PMC2556029 Disease Relevance 0 Pain Relevance 0.45

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