INT112874

Context Info Confidence 0.23 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.42 Pain Relevance 0.86

cytosol (Plcb1) signal transduction (Plcb1) cell adhesion (Plcb1) mRNA processing (Plcb1) nucleus (Plcb1) enzyme binding (Plcb1)

Anatomy Link Frequency neurons 1 Plcb1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 4 99.86 Dorsal horn 1 99.48 Inflammation 4 96.44 tail-flick 1 89.48 Acute pain 1 87.80 Pain 7 80.64 IPN 3 78.32 Glutamate receptor 2 75.00 antagonist 1 71.92 Intracerebroventricular 1 69.36

Disease Link Frequency Relevance Heat Targeted Disruption 8 97.92 INFLAMMATION 2 96.44 Nociception 4 92.84 Pain 6 87.80 Inflammatory Pain 3 78.32 Syndrome 8 51.68 Disease 25 46.96 Infection 53 29.64 Sprains And Strains 51 5.00 Viral Meningitis 22 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The genes that encode the key virulence factors PlcA, LLO, ActA, and PlcB are clustered in a 10?

Gene_expression (encode) of PlcB

1) Confidence 0.23 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2829626 Disease Relevance 0.05 Pain Relevance 0

In the dorsal horn of the spinal cord where PLCbeta1 and PLCbeta4 mRNAs are expressed, no difference was found between the wild-type and knock-out mice in the number of Fos-like immunoreactive neurons, which represent neuronal activity in the second phase in the formalin test.

Gene_expression (expressed) of PLCbeta1 in neurons associated with targeted disruption, dorsal horn and spinal cord

2) Confidence 0.05 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954872 Disease Relevance 1.37 Pain Relevance 0.86

General Comments

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