INT113101

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 41
Total Number 45
Disease Relevance 22.36
Pain Relevance 5.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl11) extracellular region (Ccl11) cytoskeleton organization (Ccl11)
Anatomy Link Frequency
lung 10
plasma 3
eosinophils 3
mast cell 3
skin 2
Ccl11 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 818 99.58 Very High Very High Very High
chemokine 233 98.40 Very High Very High Very High
cytokine 594 97.84 Very High Very High Very High
cINOD 2 96.88 Very High Very High Very High
antagonist 123 96.28 Very High Very High Very High
Inflammatory response 28 90.84 High High
tolerance 26 86.12 High High
rheumatoid arthritis 100 83.52 Quite High
Arthritis 54 76.32 Quite High
Inflammatory mediators 9 61.32 Quite High
Disease Link Frequency Relevance Heat
Eczema 438 100.00 Very High Very High Very High
Asthma 414 100.00 Very High Very High Very High
Eosinophilic Esophagitis 24 99.96 Very High Very High Very High
Rhinitis 166 99.92 Very High Very High Very High
Pulmonary Disease 367 99.84 Very High Very High Very High
Disease 418 99.72 Very High Very High Very High
Pneumonia 45 99.58 Very High Very High Very High
INFLAMMATION 798 99.40 Very High Very High Very High
Bronchial Hyperreactivity 6 98.56 Very High Very High Very High
Bronchitis 8 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To establish determination methods of eotaxin mRNA and TNF-alpha mRNA expression in the lung tissue of mice.
Gene_expression (expression) of eotaxin in lung
1) Confidence 0.76 Published 2003 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 12970926 Disease Relevance 0.07 Pain Relevance 0.07
Furthermore, the combined exposure to whole DEP + OVA significantly enhanced the expression of eotaxin.
Gene_expression (expression) of eotaxin
2) Confidence 0.75 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0 Pain Relevance 0.08
Conversely, anti-IL-13 treatment significantly inhibited CCL11 production, with no effect on CCL3 or CCL5.
Gene_expression (production) of CCL11
3) Confidence 0.66 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.20 Pain Relevance 0.34
[Expression of eotaxin mRNA and TNF-alpha mRNA in lung tissues of sensitized mice and modulation by anti-inflammatory drugs].
Gene_expression ([Expression) of eotaxin in lung associated with inflammation and cinod
4) Confidence 0.66 Published 2003 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Title Doc Link 12970926 Disease Relevance 0.10 Pain Relevance 0.10
Levels of eotaxin and IL-13 were below the detection limit of the second assay.
Gene_expression (Levels) of eotaxin
5) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 0.32 Pain Relevance 0.34
In contrast, our second series of experiments showed that DEP-OC, rather than washed DEP, enhanced allergen-related eosinophilic inflammation and proliferation of goblet cells in the airway epithelium, which was paralleled by the enhanced lung expression of eotaxin and interleukin-5.
Gene_expression (expression) of eotaxin in epithelium associated with rhinitis and inflammation
6) Confidence 0.58 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2127221 Disease Relevance 0.96 Pain Relevance 0.14
Conversely, anti-IL-13 did reduce eotaxin (CCL11) levels, whereas H4R treatment did not, perhaps suggesting a redundant role for eotaxin in this particular model.
Gene_expression (levels) of CCL11
7) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.65 Pain Relevance 0.30
Conversely, anti-IL-13 did reduce eotaxin (CCL11) levels, whereas H4R treatment did not, perhaps suggesting a redundant role for eotaxin in this particular model.
Gene_expression (reduce) of CCL11
8) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.65 Pain Relevance 0.30
To clarify the status of these genes, the same RNA samples that had been subjected to the microarray assay underwent qRT-PCR to determine differential expression of 14 genes previously associated with asthma by other investigators (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Pde4b, Pde4d, Slc7a2, Tgfb1), as well as 7 cytokine genes associated with asthma and/or pulmonary inflammation (Ifn?
Spec (determine) Gene_expression (expression) of Ccl11 associated with asthma, inflammation, pneumonia and cytokine
9) Confidence 0.56 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.38 Pain Relevance 0.13
We found significant increases in lung lavage eotaxin-1 levels in COPD patients compared to normal controls.
Gene_expression (levels) of eotaxin-1 in lung associated with pulmonary disease
10) Confidence 0.50 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.53 Pain Relevance 0.16
Moreover, the expression of both eotaxin-1 and CCR3 is up regulated during exacerbations of chronic bronchitis[43] and eotaxin-1 levels are associated with bronchodilator response and the extent of emphysema on CT scans[44].
Gene_expression (expression) of eotaxin-1 associated with emphysema and bronchitis
11) Confidence 0.50 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.42 Pain Relevance 0.15
The levels of eotaxin are significantly higher in patients
Gene_expression (levels) of eotaxin
12) Confidence 0.49 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1552025 Disease Relevance 0.51 Pain Relevance 0.10
Gene expression for eotaxin is up-regulated in ovalbumin-sensitized
Gene_expression (expression) of eotaxin
13) Confidence 0.49 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1552025 Disease Relevance 0.52 Pain Relevance 0.12
In addition, disease stability was associated with decreased plasma eotaxin-1 levels.
Gene_expression (levels) of eotaxin-1 in plasma associated with disease
14) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.38 Pain Relevance 0.17
These initial studies found that plasma IL-2 was significantly increased in stable COPD subjects compared to those with rapidly progressive disease while plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to controls.
Gene_expression (levels) of eotaxin-1 in plasma associated with pulmonary disease and disease
15) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.07 Pain Relevance 0.22
Luminex analyses focused specifically on plasma IL-2 and eotaxin-1 were conducted on an additional twenty-three COPD subjects and eight normal controls.
Gene_expression (conducted) of eotaxin-1 in plasma associated with pulmonary disease
16) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 0.10 Pain Relevance 0.13
Together, these results suggest that measuring IL-2 and eotaxin-1 levels could enable physicians to identify those COPD patients that require more intensive monitoring and treatment in the future.
Gene_expression (levels) of eotaxin-1 associated with pulmonary disease
17) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.39 Pain Relevance 0.10
Maternal DEHP exposure during neonatal periods and protein expression of eotaxin in the skin related to mite allergen in offspring
Gene_expression (expression) of eotaxin in skin
18) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535612 Disease Relevance 0.25 Pain Relevance 0.04
Eotaxin is reportedly increased in the blood of patients with atopic dermatitis (Hossny et al. 2001; Jahnz-Rozyk et al. 2005) and expressed in lesions of human atopic dermatitis (Yawalkar et al. 1999).
Gene_expression (expressed) of Eotaxin in blood associated with eczema
19) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535612 Disease Relevance 0.55 Pain Relevance 0
We evaluated the protein expression of eotaxin in the ear 24 hr after the final intradermal inoculation to elucidate the mechanism of the enhancing effects of maternal exposure to DEHP during neonatal periods on atopic dermatitis-like skin lesions related to mite allergen in males.
Gene_expression (expression) of eotaxin in skin associated with eczema
20) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535612 Disease Relevance 0.25 Pain Relevance 0.04

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