INT113281

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.97
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B)
extracellular matrix organization (TNFRSF11B)
Anatomy Link Frequency
TMJ 2
HGF 1
neutrophils 1
TNFRSF11B (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 282 98.96 Very High Very High Very High
cytokine 31 98.86 Very High Very High Very High
rheumatoid arthritis 58 98.48 Very High Very High Very High
Bioavailability 4 98.44 Very High Very High Very High
Snapping jaw 8 98.08 Very High Very High Very High
Myofascial pain syndrome 2 75.00 Quite High
Inflammation 50 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 282 98.96 Very High Very High Very High
Rheumatoid Arthritis 58 98.48 Very High Very High Very High
Temporomandibular Joint Syndrome 8 98.08 Very High Very High Very High
Celiac Disease 128 90.08 High High
Diabetes Mellitus 78 79.68 Quite High
Osteoporosis 74 75.28 Quite High
Temporomandibular Joint Disorders 2 75.00 Quite High
Necrosis 15 73.52 Quite High
Cancer 15 73.16 Quite High
Apoptosis 22 47.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, one can speculate that extracellular CS may bind the OPG heparin domain, thereby enhancing OPG bioavailability by preventing it from being degraded.
OPG Binding (bind) of associated with bioavailability
1) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.05 Pain Relevance 0.07
These results suggest that OCIF/OPG is associated with the pathogenesis of osteoarthritis of the TMJ.
OPG Binding (associated) of in TMJ associated with snapping jaw and osteoarthritis
2) Confidence 0.47 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 14505625 Disease Relevance 0.74 Pain Relevance 0.60
These results suggest that OCIF/OPG is associated with the pathogenesis of osteoarthritis of the TMJ.
OCIF Binding (associated) of in TMJ associated with snapping jaw and osteoarthritis
3) Confidence 0.47 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 14505625 Disease Relevance 0.74 Pain Relevance 0.60
OPG contains a heparin-binding domain to which some GAGs were demonstrated to bind[30].
OPG Binding (bind) of
4) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.06 Pain Relevance 0.07
Expression of RANK-L, OPG, and RANK proteins by SF neutrophils from patients with RA
OPG Binding (proteins) of in neutrophils associated with rheumatoid arthritis
5) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.46 Pain Relevance 0.23
Indeed, it has been demonstrated that even a tetrasaccharide has a very low binding affinity toward OPG heparin domain compared with a molecule containing more saccharides (that is, hexasaccharide, octosaccharide, and decasaccharide) [30].
OPG Binding (affinity) of
6) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0.03
This could be explained by the unlikelihood of modulation of extracellular OPG through a direct interaction with GS, as the affinity of GS, being a monosaccharide, toward OPG heparin-binding domain is expected to be very weak.
OPG Binding (interaction) of
7) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0.04
1, HGF, cytokines (produced by MSCs), SDF-1, RANK-L, and PGE2, as well as osteoprotegerin (OPG) interactions and indoleamine 2,3-dioxygenase (IDO) induced by INF-?
osteoprotegerin Binding (interactions) of in HGF associated with cytokine
8) Confidence 0.08 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC3021166 Disease Relevance 0 Pain Relevance 0.05
Osteoprotegerin inhibits RANKL activity by binding to it [119].
Osteoprotegerin Binding (binding) of
9) Confidence 0.02 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2905696 Disease Relevance 0.91 Pain Relevance 0.08

General Comments

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