INT113281

Context Info Confidence 0.47 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 2.97 Pain Relevance 1.78

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency TMJ 2 HGF 1 neutrophils 1 TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 282 98.96 cytokine 31 98.86 rheumatoid arthritis 58 98.48 Bioavailability 4 98.44 Snapping jaw 8 98.08 Myofascial pain syndrome 2 75.00 Inflammation 50 5.00 Pain 9 5.00 Arthritis 8 5.00 cINOD 5 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 282 98.96 Rheumatoid Arthritis 58 98.48 Temporomandibular Joint Syndrome 8 98.08 Celiac Disease 128 90.08 Diabetes Mellitus 78 79.68 Osteoporosis 74 75.28 Temporomandibular Joint Disorders 2 75.00 Necrosis 15 73.52 Cancer 15 73.16 Apoptosis 22 47.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, one can speculate that extracellular CS may bind the OPG heparin domain, thereby enhancing OPG bioavailability by preventing it from being degraded.

OPG Binding (bind) of associated with bioavailability

1) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.05 Pain Relevance 0.07

These results suggest that OCIF/OPG is associated with the pathogenesis of osteoarthritis of the TMJ.

OPG Binding (associated) of in TMJ associated with snapping jaw and osteoarthritis

2) Confidence 0.47 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 14505625 Disease Relevance 0.74 Pain Relevance 0.60

These results suggest that OCIF/OPG is associated with the pathogenesis of osteoarthritis of the TMJ.

OCIF Binding (associated) of in TMJ associated with snapping jaw and osteoarthritis

3) Confidence 0.47 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 14505625 Disease Relevance 0.74 Pain Relevance 0.60

OPG contains a heparin-binding domain to which some GAGs were demonstrated to bind[30].

OPG Binding (bind) of

4) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.06 Pain Relevance 0.07

Expression of RANK-L, OPG, and RANK proteins by SF neutrophils from patients with RA

OPG Binding (proteins) of in neutrophils associated with rheumatoid arthritis

5) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.46 Pain Relevance 0.23

Indeed, it has been demonstrated that even a tetrasaccharide has a very low binding affinity toward OPG heparin domain compared with a molecule containing more saccharides (that is, hexasaccharide, octosaccharide, and decasaccharide) [30].

OPG Binding (affinity) of

6) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0.03

This could be explained by the unlikelihood of modulation of extracellular OPG through a direct interaction with GS, as the affinity of GS, being a monosaccharide, toward OPG heparin-binding domain is expected to be very weak.

OPG Binding (interaction) of

7) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0.04

1, HGF, cytokines (produced by MSCs), SDF-1, RANK-L, and PGE2, as well as osteoprotegerin (OPG) interactions and indoleamine 2,3-dioxygenase (IDO) induced by INF-?

osteoprotegerin Binding (interactions) of in HGF associated with cytokine

8) Confidence 0.08 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC3021166 Disease Relevance 0 Pain Relevance 0.05

Osteoprotegerin inhibits RANKL activity by binding to it [119].

Osteoprotegerin Binding (binding) of

9) Confidence 0.02 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2905696 Disease Relevance 0.91 Pain Relevance 0.08

General Comments

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