INT113391

Context Info Confidence 0.35 First Reported 2003 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.50 Pain Relevance 0.27

signal transduction (Tacr1) plasma membrane (Tacr1) cytoplasm (Tacr1) signal transducer activity (Tacr1)

Tacr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 31 99.98 antagonist 6 77.28 IPN 1 75.00 Face pain 1 73.84 Inflammatory mediators 2 32.92 substance P 22 18.16 Inflammatory response 4 17.92 Pain 2 5.00 interstitial cystitis 2 5.00 Lasting pain 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 35 99.98 Nociception 1 98.84 Peripheral Arterial Disease 1 81.80 Inflammatory Pain 1 75.00 Facial Pain 1 73.84 Cystitis 15 31.48 Targeted Disruption 2 16.28 Overactive Bladder 7 5.00 Edema 6 5.00 Cancer 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Regulatory network downstream of NK1R activation

Regulation (Regulatory) of Positive_regulation (activation) of NK1R

1) Confidence 0.35 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0

These data suggest that persistent nociceptive effects associated with orofacial cutaneous inflammation depend at least in part on the activation of NK1R.

Regulation (depend) of Positive_regulation (activation) of NK1R associated with nociception and inflammation

2) Confidence 0.27 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14517596 Disease Relevance 0.50 Pain Relevance 0.27

General Comments

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