INT113453

Context Info Confidence 0.27 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 1.01

aging (Ngf, JUN) nucleoplasm (JUN) nuclear chromosome (JUN) DNA binding (JUN) cytosol (JUN) extracellular space (Ngf)

Ngf (Rattus norvegicus) JUN (Homo sapiens)

Pain Link Frequency Relevance Heat Nerve growth factor 9 100.00 Inflammation 5 94.24 Kinase C 1 92.92 IPN 2 88.24 Hyperalgesia 2 84.16 hyperexcitability 1 83.00 tissue acidosis 1 70.24 sodium channel 1 68.64 Neuropeptide 1 65.96

Disease Link Frequency Relevance Heat INFLAMMATION 4 94.24 Hyperalgesia 2 84.16 Acidosis 1 70.24 Inflammatory Pain 2 61.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NGF acts through AP1 response elements in ASIC3 encoding gene promoter.

NGF Positive_regulation (acts) of AP1 associated with nerve growth factor

1) Confidence 0.27 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.60 Pain Relevance 1.01

General Comments

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