INT113517

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 15.86
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
apoptotic cells 3
brain 1
T cell 1
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 99.48 Very High Very High Very High
opiate 12 97.76 Very High Very High Very High
withdrawal 22 97.20 Very High Very High Very High
cerebral cortex 29 96.92 Very High Very High Very High
agonist 16 96.12 Very High Very High Very High
Arthritis 118 93.72 High High
Opioid 4 93.68 High High
cytokine 25 91.20 High High
opioid receptor 2 90.36 High High
Inflammation 36 87.16 High High
Disease Link Frequency Relevance Heat
Asthma 17 100.00 Very High Very High Very High
Apoptosis 517 99.90 Very High Very High Very High
Death 164 99.70 Very High Very High Very High
Chorioamnionitis 66 99.70 Very High Very High Very High
Suicidal Behaviour 81 99.08 Very High Very High Very High
Injury 285 98.74 Very High Very High Very High
Basal Cell Carcinoma 16 98.72 Very High Very High Very High
Necrosis 12 98.72 Very High Very High Very High
Cancer 36 98.36 Very High Very High Very High
Experimental Arthritis 78 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic (5 days) heroin (5-30 mg/kg) and morphine (10-100 mg/kg) were also associated with increased native Fas (76% and 45%) and with different expressions of glycosylated Fas.
Fas Binding (associated) of associated with morphine
1) Confidence 0.37 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.30 Pain Relevance 1.13
Chronic (5 days) heroin (5-30 mg/kg) and morphine (10-100 mg/kg) were also associated with increased native Fas (76% and 45%) and with different expressions of glycosylated Fas.
Fas Binding (associated) of associated with morphine
2) Confidence 0.37 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.30 Pain Relevance 1.08
Preincubation of rat cortical membranes with N-ethylmaleimide (NEM; 1 mM for 1 h at 37 degrees C) reduced the immunodensity of approximately 203 kDa Fas aggregates (51%) and increased that of 35 kDa native Fas (172%) and 51/48 kDa glycosylated Fas (47%), indicating that disulfide bonds are involved in Fas dimerization.
Fas Binding (dimerization) of
3) Confidence 0.37 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15288576 Disease Relevance 0.08 Pain Relevance 0.45
The results indicate that Fas aggregates are natively expressed in the brain and that its density is regulated by the state of Fas glycosylation.
Fas Binding (aggregates) of in brain
4) Confidence 0.37 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15288576 Disease Relevance 0 Pain Relevance 0.56
In-vitro, fatty acid mixtures (FAs) inhibited the binding of flurbiprofen to rat serum albumin.
FAs Binding (binding) of
5) Confidence 0.26 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18088500 Disease Relevance 0.08 Pain Relevance 0.21
We therefore examined if Fas activation and estrogen could interact to regulate the expression of cyclin A, PCNA and p21/waf-1 and compared the expression of these anti-apoptotic cell cycle proteins with other cell-cycle proteins.
Fas Binding (interact) of in apoptotic cell associated with apoptosis
6) Confidence 0.21 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.58 Pain Relevance 0.03
Thus, an interpretation of our data could be that apoptosis in thermal injury rat CD4+ T cell was due to augmentation of AICD (triggered by Fas ligand) despite a deficiency in IL-2 production by thermal injury rat T cells possibly because of an increased AICD sensitivity to IL-2.
Fas Binding (ligand) of in T cell associated with injury, apoptosis and death
7) Confidence 0.20 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.67 Pain Relevance 0.07
FasMod = Moderate intensity of cell surface Fas immuno-fluorescence
Fas Binding (intensity) of
8) Confidence 0.19 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.43 Pain Relevance 0
FasHi = High intensity of cell surface Fas immuno-fluorescence
Fas Binding (intensity) of
9) Confidence 0.19 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.44 Pain Relevance 0
The highest percentage of annexin V-positive apoptotic cells was observed at 3h after Fas cross-linking.
Fas Binding (linking) of in apoptotic cells associated with apoptosis
10) Confidence 0.17 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.85 Pain Relevance 0.08
The highest percentage of annexin V-positive apoptotic cells was observed at 3h after Fas cross-linking.
Fas Binding (cross) of in apoptotic cells associated with apoptosis
11) Confidence 0.17 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.85 Pain Relevance 0.08
In this study we found significant positive associations between the carriage of the IL10 ATA haplotype, MBL2 codon 54Asp and histologic chorioamnionitis, and negative associations with TNFRSF6 and TGFB1.
TNFRSF6 Neg (negative) Binding (associations) of associated with chorioamnionitis
12) Confidence 0.16 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 0.98 Pain Relevance 0.07
, interactions between Fas and

Fas ligand, and degranulation of granules that contain granzymes and perforin.

Fas Binding (ligand) of
13) Confidence 0.15 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.77 Pain Relevance 0.37
, interactions between Fas and

Fas ligand, and degranulation of granules that contain granzymes and perforin.

Fas Binding (ligand) of
14) Confidence 0.15 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.76 Pain Relevance 0.37
We observed a significant association between smoky cabin exposure and asthma in our cohort of FAs, consistent with previous literature.
FAs Binding (association) of associated with asthma
15) Confidence 0.03 Published 2007 Journal Environ Health Section Body Doc Link PMC2064907 Disease Relevance 1.37 Pain Relevance 0.04
Normally, BCC cells fail to express FasR, thus preventing cell apoptosis via FasR-Fas ligand interaction (Berman et al 2003; Ceilley and Del Rosso 2006).


FasR Binding (interaction) of associated with apoptosis and basal cell carcinoma
16) Confidence 0.03 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503670 Disease Relevance 1.17 Pain Relevance 0
When FasR binds its ligand, namely Fas ligand (FasL), a cascade of events follows, including caspase activation, ultimately eventuating in cellular death.
FasR Binding (binds) of associated with death
17) Confidence 0.03 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503670 Disease Relevance 1.22 Pain Relevance 0.08

General Comments

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