INT113636

From wiki-pain
Revision as of 12:45, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 8.29
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hcrtr1) signal transducer activity (Hcrtr1)
Anatomy Link Frequency
spinal 3
neurons 2
spinal cord 1
nucleus 1
forebrain 1
Hcrtr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 16 100.00 Very High Very High Very High
dorsal root ganglion 14 99.84 Very High Very High Very High
Migraine 1 99.48 Very High Very High Very High
Analgesic 3 98.88 Very High Very High Very High
antagonist 6 98.80 Very High Very High Very High
Eae 2 98.70 Very High Very High Very High
isoflurane 2 98.60 Very High Very High Very High
Spinal cord 12 98.56 Very High Very High Very High
nociceptor 1 98.46 Very High Very High Very High
anesthesia 5 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 1 99.92 Very High Very High Very High
Ganglion Cysts 28 99.84 Very High Very High Very High
Diabetes Mellitus 444 99.76 Very High Very High Very High
Headache 1 99.48 Very High Very High Very High
Nociception 15 98.96 Very High Very High Very High
Neuropathic Pain 11 98.56 Very High Very High Very High
Hyperalgesia 6 98.40 Very High Very High Very High
Pain 6 97.24 Very High Very High Very High
Shock 2 90.80 High High
Hyperglycemia 4 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of spinal orexin-1 receptor produces anti-allodynic effect in the rat carrageenan test.
Positive_regulation (Activation) of orexin-1 receptor in spinal associated with neuropeptide
1) Confidence 0.70 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 14642783 Disease Relevance 0.59 Pain Relevance 0.66
Several reports have shown that orexin-positive neurons [32] as well as OX1R and OX2R [33] are activated during fasting.
Positive_regulation (activated) of OX1R in neurons
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.67 Pain Relevance 0
OX1R was also upregulated in PP-positive islets cells after the onset of diabetes (result not shown).
Positive_regulation (upregulated) of OX1R associated with diabetes mellitus
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.59 Pain Relevance 0
Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat.
Positive_regulation (activation) of orexin 1 receptor in nucleus associated with nociception and neuropeptide
4) Confidence 0.53 Published 2006 Journal Eur. J. Neurosci. Section Title Doc Link 17156207 Disease Relevance 0.36 Pain Relevance 0.42
Intrathecal and intracerebroventricular injection of orexin-A produces an analgesic effect in the formalin test and the carrageenan test and the neuropathic pain models and these effects of orexin-A are thought to be mediated by the activation of orexin-1 receptor.
Positive_regulation (activation) of orexin-1 receptor associated with eae, analgesic, intracerebroventricular and intrathecal
5) Confidence 0.52 Published 2007 Journal Masui Section Abstract Doc Link 17243644 Disease Relevance 0.43 Pain Relevance 0.61
Intravenous injection of orexin-A produces an anti-thermal hyperalgesic effect in the carrageenan test and this effect of orexin-A was mediated by the activation of orexin-1 receptor at the peripheral primary afferent terminal.
Positive_regulation (activation) of orexin-1 receptor associated with hyperalgesia
6) Confidence 0.52 Published 2007 Journal Masui Section Abstract Doc Link 17243644 Disease Relevance 0.42 Pain Relevance 0.50
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Positive_regulation (activation) of orexin-1 receptor in forebrain associated with anesthesia, neuropeptide and isoflurane
7) Confidence 0.50 Published 2006 Journal Anesthesiology Section Title Doc Link 16645455 Disease Relevance 0 Pain Relevance 0.28
These data suggest that the activation of spinal orexin-1 receptor modulates the mechanical information transmission, but not thermal information transmission, in the spinal cord during carrageenan test.
Positive_regulation (activation) of orexin-1 receptor in spinal cord associated with spinal cord
8) Confidence 0.47 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642783 Disease Relevance 0.59 Pain Relevance 0.65
The tissue level of OX1R protein increased with the duration of DM especially in type 1 diabetes where it co-localized with cleaved caspase 3 in islet cells.
Positive_regulation (increased) of OX1R protein associated with diabetes mellitus
9) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2799220 Disease Relevance 1.12 Pain Relevance 0
The increase in the number of OX1R-positive cells is associated with a high degree of co-localization with GLU.
Positive_regulation (increase) of OX1R-positive
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2799220 Disease Relevance 1.16 Pain Relevance 0
Moreover, by using whole-cell patch-clamp recordings and calcium imaging measurements we found that orexin A induced excitability and intracellular calcium concentration elevation in the isolated rat DRG neurons, which was mainly dependent on the activation of spinal orexin-1 receptor.
Positive_regulation (activation) of orexin-1 receptor in spinal associated with dorsal root ganglion and imagery
11) Confidence 0.45 Published 2008 Journal Physiol Res Section Abstract Doc Link 18973425 Disease Relevance 0.91 Pain Relevance 0.51
Morphological results show that both orexin A and orexin-1 receptor are distributed in DRG neurons.
Positive_regulation (distributed) of orexin-1 receptor in neurons associated with dorsal root ganglion
12) Confidence 0.45 Published 2008 Journal Physiol Res Section Abstract Doc Link 18973425 Disease Relevance 0.95 Pain Relevance 0.54
Endogenous orexin might be released after incision injury to activate the spinal OX1 receptors as an endogenous analgesic protector.
Positive_regulation (activate) of OX1 in spinal associated with analgesic and injury
13) Confidence 0.39 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14551290 Disease Relevance 0.50 Pain Relevance 1.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox