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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.90
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hcrt)
Anatomy Link Frequency
nucleus accumbens 1
Hcrt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 5 99.96 Very High Very High Very High
Nucleus accumbens 2 99.36 Very High Very High Very High
opioid receptor 2 98.54 Very High Very High Very High
antagonist 13 97.82 Very High Very High Very High
cocaine 14 97.28 Very High Very High Very High
methadone 5 96.74 Very High Very High Very High
narcan 3 95.36 Very High Very High Very High
intrathecal 4 88.96 High High
imagery 1 88.60 High High
allodynia 3 85.44 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 3 85.44 High High
Aging 27 83.92 Quite High
Ganglion Cysts 3 82.72 Quite High
Post Operative Pain 2 75.00 Quite High
Nociception 2 74.68 Quite High
Inflammatory Pain 1 67.88 Quite High
Sprains And Strains 1 50.40 Quite High
Sleep Disorders 75 48.80 Quite Low
Cognitive Disorder 22 5.00 Very Low Very Low Very Low
Stress 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that rats treated with vehicle, but not methadone, responded for the cocaine conditioned stimulus and displayed elevated mu-opioid receptor mRNA expression in the nucleus accumbens core and basolateral amygdala, reduced hypocretin/orexin mRNA in the lateral hypothalamus, and reduced D2 receptor mRNA in the caudate-putamen.
Negative_regulation (reduced) of hypocretin in nucleus accumbens associated with nucleus accumbens, opioid receptor, methadone, amygdala and cocaine
1) Confidence 0.57 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 18990547 Disease Relevance 0 Pain Relevance 1.05
The PKC inhibitor chelerythrine (10 and 100 microM) significantly decreased the orexin-A (200 nM)-induced [Ca(2+)](i) increase (59.4+/-4.8 % P<0.01, n=10 and 4.9+/-1.6 %, P<0.01, n=9) versus response to orexin-A).
Negative_regulation (decreased) of orexin-A
2) Confidence 0.42 Published 2010 Journal Physiol Res Section Abstract Doc Link 19537922 Disease Relevance 0.30 Pain Relevance 0.30
SB-334867, an OX1 receptor antagonist, at 30 nmol completely blocked the effect of orexin A but, even at 100 nmol, only partially antagonized the effect of orexin B.
Negative_regulation (effect) of orexin associated with antagonist
3) Confidence 0.41 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14551290 Disease Relevance 0.46 Pain Relevance 1.12
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats


Negative_regulation (Inhibition) of orexin-1
4) Confidence 0.21 Published 2008 Journal Psychopharmacology (Berl) Section Title Doc Link PMC2668563 Disease Relevance 0 Pain Relevance 0.09
In old rats there was a 10% decline in CSF Hcrt1 over the 24-h period, compared to young adult rats.
Negative_regulation (decline) of Hcrt1
5) Confidence 0.00 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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