INT113638

Context Info Confidence 0.57 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 0.90 Pain Relevance 2.63

cytoplasm (Hcrt)

Anatomy Link Frequency nucleus accumbens 1 Hcrt (Rattus norvegicus)

Pain Link Frequency Relevance Heat amygdala 5 99.96 Nucleus accumbens 2 99.36 opioid receptor 2 98.54 antagonist 13 97.82 cocaine 14 97.28 methadone 5 96.74 narcan 3 95.36 intrathecal 4 88.96 imagery 1 88.60 allodynia 3 85.44

Disease Link Frequency Relevance Heat Neuropathic Pain 3 85.44 Aging 27 83.92 Ganglion Cysts 3 82.72 Post Operative Pain 2 75.00 Nociception 2 74.68 Inflammatory Pain 1 67.88 Sprains And Strains 1 50.40 Sleep Disorders 75 48.80 Cognitive Disorder 22 5.00 Stress 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was found that rats treated with vehicle, but not methadone, responded for the cocaine conditioned stimulus and displayed elevated mu-opioid receptor mRNA expression in the nucleus accumbens core and basolateral amygdala, reduced hypocretin/orexin mRNA in the lateral hypothalamus, and reduced D2 receptor mRNA in the caudate-putamen.

Negative_regulation (reduced) of hypocretin in nucleus accumbens associated with nucleus accumbens, opioid receptor, methadone, amygdala and cocaine

1) Confidence 0.57 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 18990547 Disease Relevance 0 Pain Relevance 1.05

The PKC inhibitor chelerythrine (10 and 100 microM) significantly decreased the orexin-A (200 nM)-induced [Ca(2+)](i) increase (59.4+/-4.8 % P<0.01, n=10 and 4.9+/-1.6 %, P<0.01, n=9) versus response to orexin-A).

Negative_regulation (decreased) of orexin-A

2) Confidence 0.42 Published 2010 Journal Physiol Res Section Abstract Doc Link 19537922 Disease Relevance 0.30 Pain Relevance 0.30

SB-334867, an OX1 receptor antagonist, at 30 nmol completely blocked the effect of orexin A but, even at 100 nmol, only partially antagonized the effect of orexin B.

Negative_regulation (effect) of orexin associated with antagonist

3) Confidence 0.41 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14551290 Disease Relevance 0.46 Pain Relevance 1.12

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats Rationale

Negative_regulation (Inhibition) of orexin-1

4) Confidence 0.21 Published 2008 Journal Psychopharmacology (Berl) Section Title Doc Link PMC2668563 Disease Relevance 0 Pain Relevance 0.09

In old rats there was a 10% decline in CSF Hcrt1 over the 24-h period, compared to young adult rats.

Negative_regulation (decline) of Hcrt1

5) Confidence 0.00 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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