INT11364

Context Info Confidence 0.58 First Reported 1992 Last Reported 2008 Negated 0 Speculated 3 Reported most in Abstract Documents 4 Total Number 6 Disease Relevance 3.23 Pain Relevance 1.92

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

Anatomy Link Frequency knee 6 PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 11 100.00 Inflammation 4 100.00 metalloproteinase 9 98.48 Osteoarthritis 8 96.28 rheumatoid arthritis 5 92.96 palliative 2 5.00 methotrexate 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 11 100.00 Osteoarthritis 8 97.84 Cancer 29 96.60 Knee Osteoarthritis 3 96.48 Rheumatoid Arthritis 6 92.96 Metastasis 13 92.92 Recurrence 10 91.80 Second Primary Neoplasms 1 90.80 Death 1 85.60 Breast Cancer 34 82.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OBJECTIVES: The purpose of this study was to examine the ex vivo effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the expression of urokinase-type plasminogen activator (u-PA), PA inhibitor-1 (PAI-1) and gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] in the early knee osteoarthritis (OA) of humans.

Spec (examine) Regulation (effects) of Spec (examine) Gene_expression (expression) of u-PA in knee associated with inflammation, knee osteoarthritis, metalloproteinase, cinod and osteoarthritis

1) Confidence 0.58 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 17996201 Disease Relevance 0.35 Pain Relevance 0.47

For the univariate and multivariate analyses, we investigated the prognostic value of uPA and PAI-1 mRNA levels by using the median of expression generating "high" and "low" level groups.

Spec (investigated) Regulation (value) of Gene_expression (levels) of uPA

2) Confidence 0.44 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.95 Pain Relevance 0

The effect of indomethacin on uPA and uPAR expression in these cells was also examined.

Regulation (effect) of Gene_expression (expression) of uPA

3) Confidence 0.43 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.50 Pain Relevance 0.10

Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans.

Regulation (Effects) of Gene_expression (expression) of urokinase plasminogen in knee associated with inflammation, cinod and osteoarthritis

4) Confidence 0.42 Published 2008 Journal Clin. Biochem. Section Title Doc Link 17996201 Disease Relevance 0.29 Pain Relevance 0.46

OBJECTIVES: The purpose of this study was to examine the ex vivo effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the expression of urokinase-type plasminogen activator (u-PA), PA inhibitor-1 (PAI-1) and gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] in the early knee osteoarthritis (OA) of humans.

Spec (examine) Regulation (effects) of Spec (examine) Gene_expression (expression) of urokinase-type plasminogen activator in knee associated with inflammation, knee osteoarthritis, metalloproteinase, cinod and osteoarthritis

5) Confidence 0.37 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 17996201 Disease Relevance 0.35 Pain Relevance 0.47

The effect of therapeutic and pharmacological concentrations of tiaprofenic acid, a non-steroidal anti-inflammatory drug (NSAID), on the synthesis of the plasminogen activators, urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA), and the plasminogen activator inhibitors 1 and 2 (PAI-1 and PAI-2), by human synovial membranes isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) sufferers was evaluated.

Regulation (effect) of Gene_expression (synthesis) of uPA associated with inflammation, rheumatoid arthritis, cinod and osteoarthritis

6) Confidence 0.29 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 0.80 Pain Relevance 0.42

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