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Context Info
Confidence 0.09
First Reported 2003
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.29
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmgcr) aging (Hmgcr) endoplasmic reticulum (Hmgcr)
embryo development (Hmgcr)
Anatomy Link Frequency
vessels 1
Hmgcr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 7 93.20 High High
aspirin 11 90.88 High High
Inflammation 8 90.16 High High
Angina 2 84.56 Quite High
peripheral neuropathy 1 83.16 Quite High
dysesthesia 1 79.36 Quite High
COX-2 inhibitor 1 73.60 Quite High
diclofenac 1 68.16 Quite High
cINOD 3 67.68 Quite High
Pain 1 62.64 Quite High
Disease Link Frequency Relevance Heat
Neuropathy 11 99.36 Very High Very High Very High
INFLAMMATION 7 90.16 High High
Cardiovascular Disease 3 89.64 High High
Disease 1 89.20 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 88.56 High High
Malignant Neoplastic Disease 1 88.24 High High
Cv General 3 Under Development 2 84.56 Quite High
Peripheral Neuropathy 1 83.16 Quite High
Myocardial Infarction 1 82.28 Quite High
Dysesthesia 1 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the association between HMG-CoA reductase inhibitors and neuropathy, the risk is low compared with the significant vascular protective benefits.
HMG-CoA reductase Binding (association) of associated with neuropathy
1) Confidence 0.09 Published 2006 Journal Drug Saf Section Abstract Doc Link 16454532 Disease Relevance 1.04 Pain Relevance 0.17
Data suggest that the interaction observed involving clopidogrel and HMG-CoA reductase inhibitors appears to be significant in-vitro.
HMG-CoA reductase Binding (interaction) of
2) Confidence 0.05 Published 2006 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 17008981 Disease Relevance 0.06 Pain Relevance 0.56
Conversely, HMG-CoA reductase inhibitors (statins) can potently inhibit these proinflammatory factors in the vessels.
HMG-CoA reductase Neg (inhibit) Binding (inhibit) of in vessels
3) Confidence 0.02 Published 2003 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 14561160 Disease Relevance 1.19 Pain Relevance 0.62

General Comments

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