INT113948

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 36.06
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FLNA) extracellular region (FLNA) plasma membrane (FLNA)
nucleus (FLNA) transcription factor binding (FLNA) cytoplasm (FLNA)
Anatomy Link Frequency
renal artery 4
carotid artery 3
radial artery 2
blood vessel 1
artery 1
FLNA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 102 100.00 Very High Very High Very High
imagery 55 99.98 Very High Very High Very High
Calcium channel 14 99.28 Very High Very High Very High
mu opioid receptor 48 99.00 Very High Very High Very High
cva 77 98.62 Very High Very High Very High
opioid receptor 4 98.48 Very High Very High Very High
Inflammation 95 98.44 Very High Very High Very High
Migraine 27 97.48 Very High Very High Very High
headache 32 95.32 Very High Very High Very High
agonist 9 92.36 High High
Disease Link Frequency Relevance Heat
Fibromuscular Dyplasia 1455 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 497 100.00 Very High Very High Very High
Coronary Artery Disease 304 100.00 Very High Very High Very High
Aneurism 100 100.00 Very High Very High Very High
Cardiovascular Disease 91 100.00 Very High Very High Very High
Hyperemia 69 100.00 Very High Very High Very High
Skin Cancer 8 99.96 Very High Very High Very High
Hypertension 300 99.84 Very High Very High Very High
Syndrome 208 99.82 Very High Very High Very High
Pathologic Constriction 385 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was soon recognized that FMD could be present in carotid arteries without documented renal artery FMD or hypertension [3].
Neg (without) Gene_expression (present) of FMD in renal artery associated with fibromuscular dyplasia and hypertension
1) Confidence 0.73 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 2.00 Pain Relevance 0.04
There is no published comparative study of non-invasive tests for detecting carotid artery FMD, although Doppler ultrasound may disclose irregular patterns of stenosis that are suggestive.
Gene_expression (detecting) of FMD in carotid artery associated with fibromuscular dyplasia and pathologic constriction
2) Confidence 0.63 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 0.88 Pain Relevance 0
For example, vitamin C improved FMD in homocystinuric patients, but it did not in control participants [30].
Gene_expression (improved) of FMD
3) Confidence 0.59 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.16 Pain Relevance 0
Indeed, Stanley reported that medial and perimedial FMD lesions can coexist in the same arterial segment [6]; and Alimi et al analyzed arterial segments from 33 patients and found that more than one artery layer was involved in 25 (66%) of the 38 specimens studied [8].
Gene_expression (lesions) of FMD in artery associated with fibromuscular dyplasia
4) Confidence 0.55 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.21 Pain Relevance 0
The most common clinical presentation of FMD is renovascular hypertension secondary to renal artery involvement.
Gene_expression (presentation) of FMD in renal artery associated with fibromuscular dyplasia and hypertension
5) Confidence 0.55 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.85 Pain Relevance 0.05
It was soon recognized that FMD could be present in carotid arteries without documented renal artery FMD or hypertension [3].
Neg (without) Gene_expression (present) of FMD in renal artery associated with fibromuscular dyplasia and hypertension
6) Confidence 0.55 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 2.03 Pain Relevance 0.05
Clinical presentation in renal artery FMD
Gene_expression (presentation) of FMD in renal artery associated with fibromuscular dyplasia
7) Confidence 0.55 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.84 Pain Relevance 0
Information regarding progression in FMD is limited and retrospective, however, and the risk of progression as assessed from available studies is probably overestimated because documentation of progression was obtained from intra-arterial angiography, a procedure which is not routinely undertaken in patients with favorable clinical and biological outcomes.
Gene_expression (progression) of FMD associated with fibromuscular dyplasia
8) Confidence 0.55 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.05 Pain Relevance 0.03
Clinical presentation in carotid artery FMD
Gene_expression (presentation) of FMD in carotid artery associated with fibromuscular dyplasia
9) Confidence 0.55 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 3.09 Pain Relevance 0.27
Multivessel FMD may be rapidly progressive, particularly in young children, sometimes in a familial context [48,49].
Gene_expression (progressive) of FMD associated with fibromuscular dyplasia
10) Confidence 0.55 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.06 Pain Relevance 0.03
FMD-related aneurysms and dissection
Gene_expression (dissection) of FMD associated with fibromuscular dyplasia and aneurism
11) Confidence 0.55 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 2.06 Pain Relevance 0.04
Renal infarction in the general population commonly results from thromboembolism due to structural or arrythmical cardiac disease, but it is also associated with coagulation disorders, vasculitis, trauma and conditions of blood vessel dysfunction, such as Marfan syndrome, Ehlers-Danlos syndrome and, as presented in this case, FMD [6-8].
Gene_expression (presented) of FMD in blood vessel associated with fibromuscular dyplasia, syndrome, heart disease, injury, cva, marfan syndrome, increased venous pressure under development and infarction
12) Confidence 0.50 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2905432 Disease Relevance 2.14 Pain Relevance 0.05
Decreased percentage FMD and increased IMT was found in patients with MCTD.
Gene_expression (found) of FMD associated with systemic sclerosis and increased venous pressure under development
13) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.62 Pain Relevance 0.08
Endothelial function, as determined by FMD of the radial artery, was impaired in the study population (FMD 4.38 [4.82]%). sIL-12p7 levels were significantly higher in patients with severely impaired FMD (FMD < 4.00, n = 17), compared with normal or moderately impaired FMD (FMD >= 4, n = 21): 10.70 [10.72] versus 4.33 [7.81] pg/ml (p = 0.002) (Fig. 1).
Gene_expression (higher) of FMD in radial artery associated with increased venous pressure under development
14) Confidence 0.29 Published 2007 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2231343 Disease Relevance 1.17 Pain Relevance 0.15
Endothelial function, as determined by FMD of the radial artery, was impaired in the study population (FMD 4.38 [4.82]%). sIL-12p7 levels were significantly higher in patients with severely impaired FMD (FMD < 4.00, n = 17), compared with normal or moderately impaired FMD (FMD >= 4, n = 21): 10.70 [10.72] versus 4.33 [7.81] pg/ml (p = 0.002) (Fig. 1).
Gene_expression (higher) of FMD in radial artery associated with increased venous pressure under development
15) Confidence 0.29 Published 2007 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2231343 Disease Relevance 1.17 Pain Relevance 0.15
The FMD was expressed as the percent change in the diameter relative to the baseline diameter at rest.
Gene_expression (expressed) of FMD associated with increased venous pressure under development
16) Confidence 0.27 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2621141 Disease Relevance 0.41 Pain Relevance 0
Long-term follow-up and brachial artery FMD, carotid artery IMT, and stress ECG
Gene_expression (up) of FMD in carotid artery associated with stress and increased venous pressure under development
17) Confidence 0.24 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2621141 Disease Relevance 1.77 Pain Relevance 0.14
Since FMD and exercise testing may be affected by various medications, the therapeutic impact on the relationship among FMD, IMT, and exercise testing with respect to CAD prognostication should be investigated in future studies.
Gene_expression (prognostication) of FMD associated with coronary artery disease and increased venous pressure under development
18) Confidence 0.24 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2621141 Disease Relevance 1.01 Pain Relevance 0.08
As shown in Table 2, although the contribution of FMD and IMT towards CAD progression is not identical, both FMD and IMT were well correlated with the severity of coronary atherosclerosis.
Gene_expression (contribution) of FMD associated with coronary artery disease and increased venous pressure under development
19) Confidence 0.24 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2621141 Disease Relevance 1.14 Pain Relevance 0.09
Fluorescent studies, using confocal microscopy, provided evidence that filamin and mu opioid receptors were extensively colocalized on the membranes of filamin-expressing melanoma cells.
Gene_expression (expressing) of filamin associated with mu opioid receptor and skin cancer
20) Confidence 0.23 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573758 Disease Relevance 0.19 Pain Relevance 0.54

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