INT113961

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Context Info
Confidence 0.26
First Reported 2003
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.87
Pain Relevance 6.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (PPT1) Golgi apparatus (PPT1) cytosol (PPT1)
extracellular space (PPT1) protein modification process (PPT1) extracellular region (PPT1)
Anatomy Link Frequency
muscle 1
PPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain threshold 28 100.00 Very High Very High Very High
tolerance 10 100.00 Very High Very High Very High
diclofenac 6 99.68 Very High Very High Very High
referred pain 5 98.88 Very High Very High Very High
tramadol 200 98.68 Very High Very High Very High
Pain 26 97.90 Very High Very High Very High
antagonist 44 89.04 High High
hypoalgesia 2 75.00 Quite High
Serotonin 6 52.20 Quite High
Potency 10 32.16 Quite Low
Disease Link Frequency Relevance Heat
Pain 46 100.00 Very High Very High Very High
Referred Pain 5 98.88 Very High Very High Very High
Myalgia 2 82.56 Quite High
Hypoalagesia 2 75.00 Quite High
Stress 2 75.00 Quite High
Nociception 2 50.00 Quite Low
Pancreatitis 6 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To determine the effect of physical and mental stressors on pressure pain threshold (PPT), and pressure pain tolerance (PTOL) values, and to compare these different types of stressors on its ability to affect PPT and PTOL values in young women.
Regulation (values) of PPT associated with pain, pain threshold and tolerance
1) Confidence 0.26 Published 2009 Journal Saudi Med J Section Abstract Doc Link 19370271 Disease Relevance 0.54 Pain Relevance 0.76
OBJECTIVE: To determine the effect of physical and mental stressors on pressure pain threshold (PPT), and pressure pain tolerance (PTOL) values, and to compare these different types of stressors on its ability to affect PPT and PTOL values in young women.
Regulation (affect) of PPT associated with pain, pain threshold and tolerance
2) Confidence 0.26 Published 2009 Journal Saudi Med J Section Abstract Doc Link 19370271 Disease Relevance 0.54 Pain Relevance 0.76
In the referred pain areas, the PPTs 7.5 and 15 min after the second injection were significantly increased compared with the first injection, while no changes in the PPT were observed in local and referred pain areas after unilateral injection.
Neg (no) Regulation (changes) of PPT associated with referred pain
3) Confidence 0.24 Published 2003 Journal Eur J Pain Section Abstract Doc Link 14575666 Disease Relevance 1.16 Pain Relevance 1.16
M O-desmethyltramadol did not affect the PPT, but peristalsis was already inhibited by 10 ?
Neg (not) Regulation (affect) of PPT
4) Confidence 0.23 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1839083 Disease Relevance 0 Pain Relevance 0.73
Diclofenac-sodium did not influence the PPT and there was no difference compared to placebo.
Neg (not) Regulation (influence) of PPT associated with pain threshold and diclofenac
5) Confidence 0.23 Published 2005 Journal Pain Section Abstract Doc Link 15661432 Disease Relevance 0.81 Pain Relevance 1.16
Although the basal PPT values were lower in females, the PPT response to granisetron differed significantly between genders only in the tibialis anterior muscle.
Regulation (values) of PPT in muscle associated with pain threshold
6) Confidence 0.23 Published 2005 Journal Pain Section Abstract Doc Link 15661432 Disease Relevance 0.81 Pain Relevance 1.12
In order to obtain the net increase of PPT caused by (+)-, (-)-tramadol and O-desmethyltramadol, the baseline PPT was subtracted from the respective PPT values recorded in the presence of (+)-tramadol, (-)-tramadol and O-desmethyltramadol.


Regulation (values) of PPT associated with tramadol
7) Confidence 0.14 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1839083 Disease Relevance 0 Pain Relevance 0.41

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