INT113989

Context Info Confidence 0.44 First Reported 2003 Last Reported 2010 Negated 3 Speculated 0 Reported most in Body Documents 11 Total Number 12 Disease Relevance 7.57 Pain Relevance 0.24

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1) intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)

Anatomy Link Frequency HT-29 2 CCND1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 5 86.88 alcohol 31 75.80 Inflammation 66 70.72 Angina 1 52.88 Neuropeptide 7 50.00 cINOD 4 47.52 metalloproteinase 2 42.40 chemokine 7 39.92 cytokine 18 38.28 Inflammatory marker 3 37.56

Disease Link Frequency Relevance Heat Cancer 504 100.00 Breast Cancer 144 99.96 Mantle-cell Lymphoma 33 99.64 Prostate Cancer 8 99.60 Apoptosis 83 99.30 Reprotox - General 1 9 97.32 Malignant Neoplastic Disease 17 95.32 Death 40 93.00 Disease 65 90.20 Colon Cancer 63 88.72

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did not influence cyclinD1 nor p53 levels, as shown by immunoblotting (Fig. 3C).

Neg (nor) Regulation (influence) of Gene_expression (levels) of cyclinD1

1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.08 Pain Relevance 0

However, the cyclin D1b protein was upregulated in breast cancer, independent of cyclin D1a levels, and exhibited heterogeneous levels in breast cancer specimens.

Neg (independent) Regulation (independent) of Gene_expression (levels) of cyclin D1a associated with breast cancer

2) Confidence 0.39 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.83 Pain Relevance 0

In the present study we could not find any relation between p27 and cyclin D1 expression.

Regulation (relation) of Gene_expression (expression) of cyclin D1

3) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.69 Pain Relevance 0

In a few reports, p27 and p21 staining did not correlate significantly with any clinicopathologic parameters [28,29], but there was an association between p27 and cyclin D1 expression indicating that the balance between the two opposing regulators was important for the end result of cell cycle progression [22].

Regulation (association) of Gene_expression (expression) of cyclin D1

4) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.92 Pain Relevance 0

The STAT proteins have been implicated in resistance to apoptosis, potentially via their ability to modulate caspase 1 (ICE), Bcl-xL, and cyclin D1 expression.

Regulation (modulate) of Gene_expression (expression) of cyclin D1 associated with apoptosis

5) Confidence 0.27 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.13 Pain Relevance 0.05

The expression of several cell cycle (p21, p27, cyclin D1) and apoptotic (survivin, Bcl-xL) regulatory proteins was altered after U0126 and/or sulindac treatment.

Regulation (altered) of Gene_expression (expression) of cyclin D1

6) Confidence 0.22 Published 2003 Journal Pancreas Section Body Doc Link 14576498 Disease Relevance 0.13 Pain Relevance 0

As expected, the expression of cyclin D1 was down-regulated by the treatment of HT-29 cells with 5-FU for 24 to 48 h.

Regulation (regulated) of Gene_expression (expression) of cyclin D1 in HT-29

7) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.05 Pain Relevance 0

Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft.

Regulation (modulating) of Gene_expression (expression) of cyclin D associated with cancer and prostate cancer

8) Confidence 0.13 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 20208355 Disease Relevance 1.30 Pain Relevance 0.09

The expression of cyclin D1 was down-regulated by the treatment with 5-FU, but not affected by the pre-treatment with CQ.

Neg (not) Regulation (affected) of Gene_expression (expression) of cyclin D1

9) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.23 Pain Relevance 0

Aromatase inhibitors affected the expression of cyclin D1.

Regulation (affected) of Gene_expression (expression) of cyclin D1

10) Confidence 0.07 Published 2006 Journal Curr Cancer Drug Targets Section Abstract Doc Link 17168675 Disease Relevance 0.20 Pain Relevance 0

Intriguingly, mTOR inhibition affected cyclin D1 proteolysis only in MCL cells in which GSK-3 is under the direct control of mTOR, suggesting that different MCL subsets could be differently responsive to mTOR inhibition.

Regulation (affected) of Gene_expression (proteolysis) of cyclin D1 associated with mantle-cell lymphoma

11) Confidence 0.07 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.66 Pain Relevance 0

Tenth, polymorphisms of TNF, IL-1, IL-6, and cyclin D1 genes encountered in various cancers are all regulated by NF-?

Regulation (regulated) of Gene_expression (genes) of cyclin D1 associated with cancer

12) Confidence 0.04 Published 2008 Journal Pharm Res Section Body Doc Link PMC2515569 Disease Relevance 1.34 Pain Relevance 0.10

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