INT114189

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.39
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
plasma 1
Cort (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 19 100.00 Very High Very High Very High
isoflurane 35 99.70 Very High Very High Very High
fluoxetine 2 98.60 Very High Very High Very High
anesthesia 7 95.84 Very High Very High Very High
Eae 27 94.24 High High
Buprenorphine 7 93.08 High High
depression 19 87.52 High High
orphanin 28 86.76 High High
Opioid 1 78.60 Quite High
Pain 6 65.36 Quite High
Disease Link Frequency Relevance Heat
Stress 136 99.98 Very High Very High Very High
Anxiety Disorder 44 97.52 Very High Very High Very High
Depression 23 93.20 High High
Targeted Disruption 74 89.76 High High
Pain 6 65.36 Quite High
Aggression 30 53.60 Quite High
Brucella Infection 3 52.32 Quite High
Congenital Anomalies 3 50.00 Quite Low
Hypersensitivity 3 15.60 Low Low
Attention Deficit Hyperactivity Disorder 7 6.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although N/OFQ itself did not specifically increase CORT levels in males or females of either genotype, injection alone (either vehicle or N/OFQ) or isoflurane exposure both increased CORT levels in all groups.
Neg (not) Positive_regulation (increase) of CORT associated with isoflurane
1) Confidence 0.69 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.10 Pain Relevance 0.46
Although N/OFQ itself did not specifically increase CORT levels in males or females of either genotype, injection alone (either vehicle or N/OFQ) or isoflurane exposure both increased CORT levels in all groups.
Positive_regulation (increased) of CORT associated with isoflurane
2) Confidence 0.69 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.14 Pain Relevance 0.46
In fact, isoflurane exposure alone increased CORT levels above basal values.
Positive_regulation (increased) of CORT associated with isoflurane
3) Confidence 0.60 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.16 Pain Relevance 0.44
Finally, because even saline injection increased CORT levels, we closely investigated another possible non-specific stress effect, i.e. the effect of transporting animals from their home environment in the animal facility to the laboratory on the day of the experiment.
Positive_regulation (increased) of CORT associated with stress
4) Confidence 0.60 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.17 Pain Relevance 0.40
Although basal CORT levels were similar to values reported in other studies, circulating CORT levels were elevated in animals transported to the laboratory, even after a 30 min acclimation period.
Positive_regulation (elevated) of CORT
5) Confidence 0.60 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.15 Pain Relevance 0.31
Although basal CORT levels were similar to values reported in other studies, circulating CORT levels were elevated in animals transported to the laboratory, even after a 30 min acclimation period.
Positive_regulation (circulating) of CORT
6) Confidence 0.44 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.15 Pain Relevance 0.31
These results demonstrate that N/OFQ does not elevate circulating CORT levels; however the injection process itself results in increased CORT secretion.
Neg (not) Positive_regulation (elevate) of CORT
7) Confidence 0.41 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.15 Pain Relevance 0.46
Here we tested the hypothesis that, compared to control conditions (standard animal facility rearing, AFR) and to high levels of maternal corticosterone (H-CORT) administration (mimicking stronger neonatal stimulation), low levels of maternal corticosterone (L-CORT) would reduce within-group variation in a standardized test battery encompassing the behavioral, immune, and endocrine domain.
Positive_regulation (levels) of CORT
8) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2000350 Disease Relevance 0.44 Pain Relevance 0.09
Experiment 3 found that group-housed females had higher baseline corticosterone (CORT) levels than isolated females and fluoxetine had no effect on CORT levels.
Positive_regulation (had) of CORT associated with fluoxetine
9) Confidence 0.39 Published 2010 Journal Behav. Brain Res. Section Abstract Doc Link 19819265 Disease Relevance 0.71 Pain Relevance 0.50
KO mice, basal and stress-induced levels of corticosteroid (CORT) hormones were measured (Figure 2E).
Positive_regulation (induced) of CORT associated with stress and corticosteroid
10) Confidence 0.31 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.56 Pain Relevance 0.42
CORT levels then increased with maximal values observed at day 5 of exposure.
Positive_regulation (increased) of CORT
11) Confidence 0.31 Published 2003 Journal Clin. Immunol. Section Abstract Doc Link 14597216 Disease Relevance 0 Pain Relevance 0.49
There is a robust plasma ACTH and CORT increase in response to a single, acute SS episode in wild-type mice; however, after 10 days of repeated SS, the ACTH response is reduced in these animals (see, Figure 2—graph A: plasma ACTH levels, wild-type acute stress response vs. wild-type chronic stress response).
Positive_regulation (increase) of CORT in plasma associated with stress
12) Confidence 0.26 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.67 Pain Relevance 0

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