INT114272

Context Info Confidence 0.45 First Reported 2004 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 1.82 Pain Relevance 1.14

nucleus (Nr4a1) DNA binding (Nr4a1)

Anatomy Link Frequency nerve 4 striatum 2 eosinophil 2 Nr4a1 (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 14 99.12 Nucleus accumbens 2 85.32 antagonist 4 84.40 Nerve growth factor 1 81.40 midbrain 1 80.36 Neuropeptide 11 75.20 Enkephalin 7 69.52 corticosteroid 5 53.20 Substantia nigra 1 51.60 Ventral tegmentum 1 49.92

Disease Link Frequency Relevance Heat Apoptosis 77 100.00 Psychosis 1 87.44 Disease 21 86.88 Targeted Disruption 15 82.80 Lymphatic System Cancer 2 78.12 Catalepsy 4 77.04 Diffuse Large B-cell Lymphoma 1 77.04 INFLAMMATION 16 41.20 Asthma 24 39.28 Fibrosis 2 31.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have previously shown that dopamine (DA) denervation and repeated L-DOPA treatment modulate the pattern of Nur77 mRNA expression in the striatum.

Regulation (modulate) of Gene_expression (expression) of Nur77 in striatum associated with dopamine

1) Confidence 0.45 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930409 Disease Relevance 0.16 Pain Relevance 0.24

We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.

Regulation (modulated) of Gene_expression (expression) of NGFI-B in nerve

2) Confidence 0.45 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.36 Pain Relevance 0.28

We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.

Regulation (modulated) of Gene_expression (expression) of Nur77 in nerve

3) Confidence 0.45 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.37 Pain Relevance 0.28

Modulation of Nur77 and Nor-1 mRNA expression by antipsychotics can be used to calculate an index that is predictive of the typical or atypical profile of antipsychotic drugs.

Regulation (Modulation) of Gene_expression (expression) of Nur77

4) Confidence 0.34 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.09 Pain Relevance 0.27

CD30 stimulation recently has been shown to cause eosinophil-specific apoptosis.142 It has been further reported that CD30 stimulation markedly induced Nur77 and NOR1, NR4A nuclear receptor family, during eosinophil-specific apoptosis.143 However, CD30 stimulation did not alter Nurr1 expression in this system.

Neg (not) Regulation (alter) of Gene_expression (expression) of Nur77 in eosinophil associated with apoptosis

5) Confidence 0.04 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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