INT114274

Context Info Confidence 0.70 First Reported 2004 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 67 Total Number 67 Disease Relevance 36.77 Pain Relevance 12.50

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra) transcription factor binding (Rxra)

Anatomy Link Frequency hepatocyte 4 CAR 3 spinal cord 2 epithelial cells 2 nerve 2 Rxra (Mus musculus)

Pain Link Frequency Relevance Heat agonist 638 100.00 Inflammation 1341 99.98 Spinal cord 492 99.72 Peripheral nerve injury 30 99.72 Peripheral nervous system 91 99.28 cytokine 331 96.76 Central nervous system 256 96.16 cINOD 179 96.04 Arthritis 43 94.84 Multiple sclerosis 2 93.68

Disease Link Frequency Relevance Heat INFLAMMATION 1733 99.98 Infertility 1 99.98 Rheumatoid Arthritis 878 99.92 Obesity 417 99.84 Frailty 300 99.72 Keloid Scars 16 99.56 Nervous System Injury 60 99.28 Injury 383 98.92 Lung Cancer 27 98.28 Osteogenic Sarcomas 86 97.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

express RXR?

Gene_expression (express) of RXR

1) Confidence 0.70 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.39 Pain Relevance 0.46

agonists of either RXR or PPAR, leading to the activation of

Gene_expression (agonists) of RXR associated with agonist

2) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.29 Pain Relevance 0.30

exclusively in hepatocytes [10], RXR?

Gene_expression (exclusively) of RXR in hepatocytes

3) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.38 Pain Relevance 0.43

agonists of either RXR or PPAR, leading to the activation of

Gene_expression (either) of RXR associated with agonist

4) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.29 Pain Relevance 0.30

The RXR/PPAR heterodimer is activated by

Gene_expression (heterodimer) of RXR

5) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.30 Pain Relevance 0.30

PPARs in the absence of RXR?

Neg (absence) Gene_expression (absence) of RXR

6) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.38 Pain Relevance 0.48

deleting hepatocyte-specific RXR?

Gene_expression (specific) of RXR in hepatocyte

7) Confidence 0.53 Published 2006 Journal PPAR Research Section Abstract Doc Link PMC1664714 Disease Relevance 0.37 Pain Relevance 0.32

that the hepatocyte-specific RXR?

Gene_expression (specific) of RXR in hepatocyte

8) Confidence 0.53 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.72 Pain Relevance 0.46

deleting hepatocyte-specific RXR?

Gene_expression (deleting) of RXR in hepatocyte

9) Confidence 0.53 Published 2006 Journal PPAR Research Section Abstract Doc Link PMC1664714 Disease Relevance 0.37 Pain Relevance 0.32

In addition, we demonstrate that haloperidol enhances colocalization of NGFI-B and RXRgamma1 isoform mRNAs, suggesting that both NGFI-B and a RXR isoform are highly coexpressed after haloperidol administration.

Gene_expression (coexpressed) of RXR isoform

10) Confidence 0.48 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.33 Pain Relevance 0.48

We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.

Gene_expression (expression) of retinoid X receptor in nerve

11) Confidence 0.48 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.38 Pain Relevance 0.29

We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.

Gene_expression (expression) of RXR in nerve

12) Confidence 0.48 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.38 Pain Relevance 0.29

There is evidence suggesting that the relative expression level of different NRs and RXR dictates the activity of individual NR pathways.

Gene_expression (expression) of RXR

13) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.12 Pain Relevance 0

sterility observed in RXR?

Gene_expression (observed) of RXR associated with infertility

14) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266973 Disease Relevance 0.16 Pain Relevance 0

The crystal structures of several RXR/partner LBD heterodimers have been resolved since the publication of the RXR LBD homodimer, including RXR/RAR [39, 40], RXR/CAR [41, 42], RXR/LXR [43, 44], and RXR/PPAR [25, 45–47].

Gene_expression (/) of RXR in CAR

15) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

Interestingly, RAR acquires the heterodimerization properties of RXR when its I-box is replaced by that of the RXR, and vice versa [57].

Gene_expression (acquires) of RXR

16) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

Our laboratory has created and tested an engineered RXR/PPAR heterodimer consist of mouse RXR?

Gene_expression (consist) of RXR

17) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.07 Pain Relevance 0

The creation of these mutants is based on the proposed salt-bridge between RXR?

Gene_expression (bridge) of RXR in bridge

18) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.06 Pain Relevance 0

The crystal structures of several RXR/partner LBD heterodimers have been resolved since the publication of the RXR LBD homodimer, including RXR/RAR [39, 40], RXR/CAR [41, 42], RXR/LXR [43, 44], and RXR/PPAR [25, 45–47].

Gene_expression (/) of RXR in CAR

19) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

This inhibition can be relieved by the addition of RXR?

Gene_expression (addition) of RXR

20) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.