INT114294

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.09
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymphocytes 2
Fcer2a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 36 100.00 Very High Very High Very High
Inflammation 103 99.64 Very High Very High Very High
cINOD 2 83.20 Quite High
Inflammatory response 6 70.56 Quite High
tolerance 15 25.28 Quite Low
Freund adjuvant 12 5.00 Very Low Very Low Very Low
Nerve growth factor 11 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhinitis 12 99.88 Very High Very High Very High
INFLAMMATION 112 99.64 Very High Very High Very High
Hypersensitivity 138 97.48 Very High Very High Very High
Immunization 24 96.24 Very High Very High Very High
Disease 20 93.04 High High
Asthma 82 92.52 High High
Airway Obstruction 2 74.84 Quite High
Diarrhoea 6 73.76 Quite High
Respiratory Tract Allergy 1 69.20 Quite High
Leukemia 6 51.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of adult mice to LPS suppressed IgE production, airway inflammation, and development of bronchial hyperresponsiveness (Gerhold et al. 2003).
Negative_regulation (suppressed) of Gene_expression (production) of IgE associated with inflammation
1) Confidence 0.14 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.40 Pain Relevance 0.05
In contrast, serum IgE levels at day 14, after a single injection, were not significantly elevated (p = 0.438) compared to naïve mice.
Neg (not) Negative_regulation (compared) of Gene_expression (levels) of IgE
2) Confidence 0.12 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0 Pain Relevance 0
The serum level of IgE, IL-6 and MCP-1 was decreased in PG102-treated mice.
Negative_regulation (decreased) of Gene_expression (level) of IgE
3) Confidence 0.09 Published 2009 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 19439982 Disease Relevance 0.43 Pain Relevance 0
Inhalation of APC significantly inhibited the expression of T helper 2 (Th2) cytokines, immunoglobulin E (IgE), eosinophilic inflammation, and hyperresponsiveness.
Negative_regulation (inhibited) of Gene_expression (expression) of IgE associated with rhinitis, inflammation and cytokine
4) Confidence 0.07 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 1.00 Pain Relevance 0.48
Downregulation of allergen specific IgE production by DNA vaccination
Negative_regulation (Downregulation) of Gene_expression (production) of IgE
5) Confidence 0.06 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.19 Pain Relevance 0.03
Thus, in vivo total and allergen-specific IgE synthesis might be efficiently inhibited by DNA vaccination.


Negative_regulation (inhibited) of Gene_expression (synthesis) of IgE
6) Confidence 0.06 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.33 Pain Relevance 0.12
APC also significantly suppressed the expression of Th2 cytokines and IgE from lymphocytes isolated from OVA-sensitized/challenged animals.
Negative_regulation (suppressed) of Gene_expression (expression) of IgE in lymphocytes associated with cytokine
7) Confidence 0.05 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 0.95 Pain Relevance 0.48
DNA vaccine with plasmid encoding the major HDM allergens might inhibit IgE synthesis more efficiently than encoding one of the HDM allergens.
Spec (might) Negative_regulation (inhibit) of Gene_expression (synthesis) of IgE
8) Confidence 0.04 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.80 Pain Relevance 0.08

General Comments

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