INT114505

Context Info Confidence 0.01 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0.60

cytoplasm (Hmmr, Casp3) cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3) nucleus (Casp3) intracellular (Casp3)

Anatomy Link Frequency liver 2 Hmmr (Mus musculus) Casp3 (Mus musculus)

Pain Link Frequency Relevance Heat qutenza 2 99.78 primary afferent fibers 2 99.34 antagonist 5 92.28 substance P 6 91.04 cytokine 2 88.08

Disease Link Frequency Relevance Heat Hepatotoxicity 4 93.96 Apoptosis 5 93.24 Injury 2 76.64 Cancer 2 75.00 Necrosis 2 75.00 Disease 1 75.00 Liver Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Depletion of primary afferent nerve fibers by neonatal capsaicin treatment prevented CD95-mediated activation of caspase-3, measured as enzymatic activity in liver homogenates or by demonstration of hepatocellular immunoreactivity for active caspase-3 in liver slices, and liver damage.

Negative_regulation (prevented) of CD95-mediated Positive_regulation (activation) of caspase-3 in liver associated with qutenza, primary afferent fibers and hepatotoxicity

1) Confidence 0.01 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14617692 Disease Relevance 0.72 Pain Relevance 0.60

General Comments

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