INT114704

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.89
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
embryo 2
nucleus 1
fibroblast 1
HGF 1
neural 1
Fgf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 25 100.00 Very High Very High Very High
agonist 13 99.16 Very High Very High Very High
Inflammation 37 99.12 Very High Very High Very High
Potency 2 96.80 Very High Very High Very High
ischemia 19 95.36 Very High Very High Very High
fibrosis 16 92.28 High High
anesthesia 5 79.80 Quite High
chemokine 13 58.88 Quite High
midbrain 36 52.24 Quite High
Pain 6 49.36 Quite Low
Disease Link Frequency Relevance Heat
Stress 40 99.68 Very High Very High Very High
INFLAMMATION 43 99.12 Very High Very High Very High
Cancer 268 98.72 Very High Very High Very High
Apoptosis 95 98.04 Very High Very High Very High
Metaplasia 8 98.04 Very High Very High Very High
Wilms Tumor 1 97.44 Very High Very High Very High
Hypoxia 47 97.20 Very High Very High Very High
Prostate Cancer 34 97.04 Very High Very High Very High
Neurodegenerative Disease 11 96.42 Very High Very High Very High
Cv Unclassified Under Development 12 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microarray results from cells invading matrigel are consist with above suggestion, since high fat diet stimulated the gene expression of numerous proangiogenic factors like Vegf, Egf, Fgf1, Hbegf, Pdgfa, Fgf18.
Positive_regulation (stimulated) of Fgf1 in fat
1) Confidence 0.50 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.44 Pain Relevance 0.05
An ancestral gene of the canonical Fgf subfamily, Fgf4-like, was generated from Fgf13-like by gene duplication during the early stages of metazoan evolution.
Positive_regulation (generated) of Fgf
2) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.38 Pain Relevance 0
Northern blotting demonstrated a significant upregulation of syndecan-1, -2, -3, and -4, WT-1, fibronectin, and basic fibroblast growth factor (FGF) receptor 1.
Positive_regulation (upregulation) of FGF in fibroblast
3) Confidence 0.25 Published 2004 Journal Physiol. Genomics Section Abstract Doc Link 14625378 Disease Relevance 0.57 Pain Relevance 0.08
Based on our findings, we suggest that tissue metaplasia in arthrofibrosis results from increased inflammatory-associated oxidative stress, leading to an accumulation of mast cells (secreting FGF), driving fibroblast proliferation and creating avascular regions of hypoxia.
Positive_regulation (accumulation) of FGF in mast cells associated with stress, inflammation, hypoxia and metaplasia
4) Confidence 0.18 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 2.32 Pain Relevance 0.23
During conditions of low oxygen tension, various components of the transcription factor dimerize and coordinately translocate into the nucleus causing upregulation of numerous cytokines and proteins associated with angiogenesis such as SDF-1, VEGF, FGF, and matrix metalloproteases [89].
Positive_regulation (upregulation) of FGF in nucleus associated with cytokine
5) Confidence 0.16 Published 2007 Journal J Transl Med Section Body Doc Link PMC1914111 Disease Relevance 1.21 Pain Relevance 0.40
By using the Xenopus embryo, we have previously demonstrated that inhibition of the BMP pathway is sufficient for neural induction[8] and activation of FGF pathway is required for both neural induction and caudalization[38].
Positive_regulation (activation) of FGF in embryo
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0
These data suggest that FGF signaling is required for neural induction from hiPSC as well as hESC.


Positive_regulation (required) of FGF in neural
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0
To test the requirement of FGF signaling, we treated some of the cells with 5 µM SU5402, a chemical inhibitor of FGF receptors, added at days 4, 6 and 8 of differentiation.
Positive_regulation (requirement) of FGF
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0.20 Pain Relevance 0
Thus, increased levels of several growth factors, including FGF, EGF, IL-6 and GPCR agonists that activate anti-apoptotic signaling pathways, have been reported in androgen-independent prostate cancer [3]–[7].
Positive_regulation (increased) of FGF associated with agonist, prostate cancer and apoptosis
9) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.39 Pain Relevance 0.05
Neurogenesis occurs when bone morphogenetic protein (BMP) signaling is inhibited, as we[8] and others[9], [10] first demonstrated in the Xenopus embryo, and/or when fibroblast growth factor (FGF) signaling is activated[11].
Positive_regulation (activated) of FGF in embryo associated with neurodegenerative disease
10) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0.30 Pain Relevance 0.03
Many growth and endocrine factors are able to activate p38 MAP kinase including FGF-1 and -2, keratinocyte-derived growth factor (KGF), IL-6, heparin binding epidermal growth factor (HB-EGF), ATP, vitamin D, and Neu differentiation factor (NDF) [13,25,47,79-81].
Positive_regulation (activate) of FGF-1 in keratinocyte
11) Confidence 0.06 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.65 Pain Relevance 0
On the basis of our in vitro tumor growth assay data, we conclude that the MSC produced paracrine factors HGF, FGF, TGF-?
Positive_regulation (factors) of FGF in HGF associated with cancer
12) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.61 Pain Relevance 0
of FGF are increased, the density of CXCR4 receptors is reduced [31].
Positive_regulation (increased) of FGF
13) Confidence 0.03 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.81 Pain Relevance 0.06

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