INT114750

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.68
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) signal transduction (Bdkrb2) plasma membrane (Bdkrb2)
signal transducer activity (Bdkrb2)
Anatomy Link Frequency
neurons 3
satellite cells 1
Bdkrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 105 100.00 Very High Very High Very High
b2 receptor 33 100.00 Very High Very High Very High
antagonist 17 100.00 Very High Very High Very High
B1 receptor 15 99.12 Very High Very High Very High
dorsal root ganglion 10 97.40 Very High Very High Very High
unmyelinated 4 96.92 Very High Very High Very High
Opioid 7 95.28 Very High Very High Very High
bradykinin 61 91.44 High High
Morphine 18 89.72 High High
agonist 18 86.88 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 99.96 Very High Very High Very High
Ganglion Cysts 10 97.40 Very High Very High Very High
Nociception 14 91.20 High High
INFLAMMATION 23 82.56 Quite High
Asthma 15 82.04 Quite High
Stress 8 62.72 Quite High
Hyperalgesia 2 50.80 Quite High
Pain 2 50.12 Quite High
Aids-related Complex 3 39.72 Quite Low
Nicotine Addiction 12 9.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After nerve injury, B2 receptor expression drastically decreased, whereas B1 receptors were newly expressed mainly in myelinated DRG neurons and satellite cells.
Negative_regulation (decreased) of Gene_expression (expression) of B2 receptor in neurons associated with dorsal root ganglion, nervous system injury and b2 receptor
1) Confidence 0.17 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 1.20 Pain Relevance 1.27
Our pharmacological dissection of drug-regulated gene expression profiles showed the inhibitory effects of CRFR1 and GR antagonists on ethanol-activated gene expression of the B2 and B3 subclusters.
Negative_regulation (effects) of Gene_expression (expression) of B2 associated with antagonist
2) Confidence 0.12 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.06 Pain Relevance 0.41
After nerve injury, B2 receptor expression drastically decreased, whereas B1 receptors were newly expressed mainly in myelinated DRG neurons and satellite cells.
Negative_regulation (decreased) of in satellite cells Gene_expression (expression) of B2 receptor in neurons associated with dorsal root ganglion, nervous system injury and b2 receptor
3) Confidence 0.06 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 1.20 Pain Relevance 1.27
The decrease in receptor-mediated contractions is paralleled with a significant decrease in nicotine-enhanced kinin B1 and B2 receptor mRNA expression shown by real-time PCR (Fig. 4B).
Negative_regulation (decrease) of Gene_expression (expression) of B2 receptor mRNA associated with nicotine and b2 receptor
4) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.22 Pain Relevance 0.69

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