INT11479

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Context Info
Confidence 0.68
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 10.07
Pain Relevance 10.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
myometrium 1
plasma 1
pore 1
fibroblast 1
nociceptors 1
KCNMA1 (Homo sapiens)
KCNMA1 - D1790G (1)
Pain Link Frequency Relevance Heat
Pain 233 100.00 Very High Very High Very High
potassium channel 113 100.00 Very High Very High Very High
bradykinin 60 100.00 Very High Very High Very High
TRP channel 2 100.00 Very High Very High Very High
agonist 9 99.92 Very High Very High Very High
qutenza 25 99.86 Very High Very High Very High
Nerve growth factor 13 98.78 Very High Very High Very High
antagonist 20 98.36 Very High Very High Very High
adenocard 2 97.74 Very High Very High Very High
lidocaine 2 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 238 100.00 Very High Very High Very High
Hypersensitivity 7 100.00 Very High Very High Very High
Pressure And Volume Under Development 3 99.52 Very High Very High Very High
Coagulation Disorder 2 99.16 Very High Very High Very High
Endotoxemia 2 98.44 Very High Very High Very High
Hypertension 2 97.92 Very High Very High Very High
Nociception 22 97.80 Very High Very High Very High
INFLAMMATION 33 97.36 Very High Very High Very High
Hereditary Angioedema 2 96.20 Very High Very High Very High
Somatoform Disorder 96 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human dermal fibroblast, PKA is involved in activation of the KCNMA1 by nitric oxide through cGMP [44].
Positive_regulation (activation) of KCNMA1 in fibroblast
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.18 Pain Relevance 0
KCNMA1 activation has a great impact on the membrane and plays role in muscle tone/contractility and neuronal activity [32] as well as blood pressure regulation [33]; (b) PRKG1, a serine-threonine kinase located in the cytoplasm with a key role in nitric oxide/cyclic guanosine monophosphate (cGMP) signaling.
Positive_regulation (activation) of KCNMA1 in blood
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.41 Pain Relevance 0
An increased proportion of myometrial Maxi-K ?
Positive_regulation (increased) of Maxi-K
3) Confidence 0.41 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Iberiotoxin (50 nM), a selective blocker of large-conductance, voltage-gated Ca2+-activated K+ (K(Ca)) (BK) channel, dramatically increased both contraction amplitude and frequency whereas NS-1619 (30 microM), which increases BK channel activity, decreased them.
Positive_regulation (increases) of channel
4) Confidence 0.12 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11736694 Disease Relevance 0 Pain Relevance 0.08
The potencies and efficacies of three 5-HT3 receptor agonists in inducing currents through the ion channel and the potencies of two 5-HT3 receptor antagonists in blocking 5-HT-evoked currents did not differ between wild-type and variant receptors.
Positive_regulation (inducing) of channel associated with antagonist and agonist
5) Confidence 0.10 Published 2004 Journal Pharmacogenetics Section Abstract Doc Link 15167704 Disease Relevance 0.48 Pain Relevance 0.43
The calcium-dependent hypothesis would require that stretch increases intracellular Ca2+ and that this activates the BK channel.
Positive_regulation (activates) of BK channel associated with potassium channel
6) Confidence 0.05 Published 2010 Journal Journal of Cellular Physiology Section Body Doc Link PMC2883078 Disease Relevance 0.06 Pain Relevance 0.13
Menthol, popularly known for its cooling effect, activates TRPM8--a cold-activated thermoTRP ion channel.
Positive_regulation (activates) of channel
7) Confidence 0.05 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16829128 Disease Relevance 0.10 Pain Relevance 0.18
In all these cases increased BK levels is the hallmark.
Positive_regulation (increased) of BK associated with bradykinin
8) Confidence 0.05 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.63 Pain Relevance 0.60
In others, the inability of angiotensin converting enzyme (ACE) to degrade BK leads to elevated BK levels and edema in patients on ACE inhibitors.
Positive_regulation (elevated) of BK associated with pressure and volume under development and bradykinin
9) Confidence 0.05 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.61 Pain Relevance 0.60
Bradykinin (BK), an important mediator of allergic reactions and pain induction, is released by the activation of the plasma kallikrein-kinin (K-K) cascade.
Positive_regulation (induction) of BK in plasma associated with pain, hypersensitivity and bradykinin
10) Confidence 0.05 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1562287 Disease Relevance 0.29 Pain Relevance 0.23
Although claimed to be absent in murine myometrium [18], we have described the expression of the potassium channels, subfamily K, member 4 (KCNK4) a two-pore potassium channel (K2P4.1) known as TRAAK (TWIK-related arachidonic acid-stimulated K+ channel) and member 2 (KCNK2) a two-pore potassium channel (K2P2.1) known as TREK-1 (TWIK-related K+ channel) in human myometrium [19] as did Bai et al. in the same year [20].
Positive_regulation (stimulated) of channel in myometrium associated with potassium channel
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.14 Pain Relevance 0.36
Fig. 6A) were blunted by the addition of AA compared to control consistent with TREK-1 channel activation (Fig. 6C).
Positive_regulation (activation) of channel
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.09
This report of a regulated increase in both expression as well as channel function supports our hypothesis that TREK-1 channels are important in maintaining quiescence during pregnancy and that channel expression and or activation may be dysregulated in spontaneous pre-term labor.
Positive_regulation (increase) of channel
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.05 Pain Relevance 0.07
CONCLUSIONS: These results (1) demonstrate that the DG mutation confers a unique pharmacological response on expressed channels; (2) suggest that flecainide use-dependent block of DG channels underlies its therapeutic effects in carriers of this gene mutation; and (3) suggest a role of the Na(+) channel alpha-subunit C-terminus in the flecainide/channel interaction.


Positive_regulation (role) of channel
14) Confidence 0.04 Published 2000 Journal Circulation Section Body Doc Link 10952963 Disease Relevance 0.06 Pain Relevance 0
Both contractile and relaxation responses to BK and the release of the prostanoids PGE2, PGI2, and TXA2 by the airway tissues were largely inhibited by indomethacin, whereas TTX had no effect.
Positive_regulation (responses) of BK associated with tetrodotoxin and bradykinin
15) Confidence 0.04 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7921430 Disease Relevance 0 Pain Relevance 0.76
D1790G (DG), an LQT-3 mutation of the C-terminal region of the Na(+) channel alpha-subunit, alters steady-state inactivation of expressed channels but does not promote sustained Na(+) channel activity.
Neg (not) Positive_regulation (promote) of channel (D1790G)
16) Confidence 0.04 Published 2000 Journal Circulation Section Abstract Doc Link 10952963 Disease Relevance 0.17 Pain Relevance 0.14
We investigated the effects of bradykinin (BK) on the production of interleukin (IL)-6 and prostaglandin PGE(2), whose molecules are capable of stimulating the development of osteoclasts from their hematopoietic precursors as well as the signal transduction systems involved, in human osteoblasts (SaM-1 cells).
Positive_regulation (effects) of BK in osteoblasts associated with bradykinin
17) Confidence 0.04 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.22 Pain Relevance 0.37
TRPV1 is a cation channel activated by a range of noxious stimuli and highly expressed in nociceptive fibres.
Positive_regulation (activated) of channel associated with nociception
18) Confidence 0.03 Published 2007 Journal Pain Section Abstract Doc Link 17659837 Disease Relevance 0.66 Pain Relevance 0.54
Kinetic analysis revealed that this drug did not alter the channel activation or deactivation time courses.
Positive_regulation (activation) of channel
19) Confidence 0.02 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10493112 Disease Relevance 0.07 Pain Relevance 0.11
Moreover, there is also evidence that various inflammatory mediators such as adenosine triphosphate (ATP), bradykinin, nerve growth factor (NGF) or prostaglandin E(2) (PGE(2)) may indirectly lead to activation of the TRPV1 channel via activation of their respective receptors.
Positive_regulation (activation) of channel in nerve associated with adenocard, inflammatory mediators, nerve growth factor and bradykinin
20) Confidence 0.01 Published 2009 Journal Pulm Pharmacol Ther Section Abstract Doc Link 19141328 Disease Relevance 1.45 Pain Relevance 0.80

General Comments

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