INT114953

Context Info Confidence 0.29 First Reported 2003 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 23 Total Number 31 Disease Relevance 16.58 Pain Relevance 2.02

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)

Anatomy Link Frequency CAR 1 colon 1 NR1H4 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 31 99.04 agonist 309 98.08 Inflammation 156 87.92 metalloproteinase 116 85.40 cytokine 59 77.04 imagery 5 75.44 antagonist 22 66.24 Arthritis 24 33.84 diclofenac 1 33.44 COX-2 inhibitor 8 22.44

Disease Link Frequency Relevance Heat Colon Cancer 343 99.76 Carcinoma 149 99.76 Myeloid Leukemia 56 99.68 Apoptosis 261 99.20 Rheumatoid Arthritis 280 99.08 Leukemia 162 99.08 INFLAMMATION 184 98.80 Multiple Myeloma 44 97.68 Lymphatic System Cancer 70 94.64 Malignant Neoplastic Disease 89 93.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Of these dimers, only RXR:PPAR?

Gene_expression (only) of RXR

1) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.14 Pain Relevance 0.06

In addition, we document that this inhibition is transcriptionally mediated and involves genetic and epigenetic mechanisms but does not appear to involve competitive binding between RXR:PPAR?

Gene_expression (competitive) of RXR

2) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0

, ligands block MMP-1 and MMP-13 gene expression, RXR:PPAR?

Gene_expression (expression) of RXR

3) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.15 Pain Relevance 0.04

binding to the DR-1/AP-1 site in suppressing MMP-1 and MMP-13 production and addressed possible mechanisms of inhibition, including competitive binding between RXR:PPAR?

Gene_expression (competitive) of RXR

4) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0.03

These data may be explained by the fact that, when RXR and PPAR?

Gene_expression (explained) of RXR

5) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

As shown in Figure 9b, no SUMOylated RXR is present in untreated cells or in cells treated with IL-1?

Gene_expression (present) of RXR

6) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.07 Pain Relevance 0.03

-induced expression of MMP-1 and MMP-13 by combinatorial treatment with RXR and PPAR?

Gene_expression (expression) of RXR

7) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656243 Disease Relevance 0.17 Pain Relevance 0.12

The presence of RXR and PPAR?

Gene_expression (presence) of RXR

8) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.16 Pain Relevance 0.08

requires a high-level expression of RXR?

Gene_expression (expression) of RXR

9) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.81 Pain Relevance 0.25

expression of p-RXR?

Gene_expression (expression) of RXR

10) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.85 Pain Relevance 0

express high levels of p-RXR?

Gene_expression (express) of RXR

11) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.02 Pain Relevance 0.04

in both human HCC tissues and a human HCC cell line, whereas RXR?

Gene_expression (whereas) of RXR associated with carcinoma

12) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.69 Pain Relevance 0

the cooperation of RXR?

Gene_expression (cooperation) of RXR

13) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.27 Pain Relevance 0

Therefore, the activation of the RXR/PPAR?

Gene_expression (/) of RXR

14) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.80 Pain Relevance 0.25

These findings suggest that RXR?

Spec (suggest) Gene_expression (suggest) of RXR

15) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.40 Pain Relevance 0

A malfunction of RXR?

Gene_expression (malfunction) of RXR

16) Confidence 0.22 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2408709 Disease Relevance 0.47 Pain Relevance 0

for both RXR and RAR [34, 35], can restore the function of RXR?

Gene_expression (function) of RXR

17) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.56 Pain Relevance 0.05

/RXR-dependent

Gene_expression (dependent) of RXR

18) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.22 Pain Relevance 0.12

We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive.

Gene_expression (expression) of RXR associated with agonist

19) Confidence 0.11 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646253 Disease Relevance 0.24 Pain Relevance 0.54

Thus, on DR3 and DR5, RXR occupies the 5?

Gene_expression (occupies) of RXR

20) Confidence 0.05 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0

General Comments

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