INT11529

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.96
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Acox1) mitochondrion (Acox1) peroxisome (Acox1)
lipid metabolic process (Acox1) cytoplasm (Acox1)
Acox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 75.00 Quite High
anesthesia 2 66.08 Quite High
imagery 2 62.24 Quite High
Disease Link Frequency Relevance Heat
Adrenoleukodystrophy 6 93.92 High High
INFLAMMATION 1 75.00 Quite High
Muscle Hypotonia 2 72.08 Quite High
Convulsion 2 70.48 Quite High
Ocular Toxicity (including Many Sub-types) 4 68.32 Quite High
Disease 2 56.00 Quite High
Neurological Disease 2 47.60 Quite Low
Cognitive Disorder 2 45.12 Quite Low
Neuropathic Pain 2 38.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paradoxically, R-ketoprofen which is extensively inverted in rats was a non-competitive inhibitor of palmitoyl-CoA formation by the high affinity isoform suggesting that it may not act as an alternate substrate.
Negative_regulation (inhibitor) of Gene_expression (formation) of palmitoyl-CoA
1) Confidence 0.37 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1567471 Disease Relevance 0.07 Pain Relevance 0.07
The disorders of peroxisomal beta-oxidation, which have been well characterised at the molecular level, include defects of acyl-CoA oxidase, defects of the D-bifunctional protein (D-BP) (including specific defects of its enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase components), defects of the very-long-chain fatty acid (VLCFA)-CoA importer [X-linked adrenoleukodystrophy (ALD)] and alpha-methylacyl-CoA racemase deficiency.
Negative_regulation (defects) of Gene_expression (defects) of acyl-CoA oxidase associated with adrenoleukodystrophy
2) Confidence 0.03 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11356171 Disease Relevance 0.43 Pain Relevance 0.09
The disorders of peroxisomal beta-oxidation, which have been well characterised at the molecular level, include defects of acyl-CoA oxidase, defects of the D-bifunctional protein (D-BP) (including specific defects of its enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase components), defects of the very-long-chain fatty acid (VLCFA)-CoA importer [X-linked adrenoleukodystrophy (ALD)] and alpha-methylacyl-CoA racemase deficiency.
Negative_regulation (defects) of Gene_expression (defects) of acyl-CoA oxidase associated with adrenoleukodystrophy
3) Confidence 0.03 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11356171 Disease Relevance 0.45 Pain Relevance 0.10

General Comments

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