INT11553

Context Info Confidence 0.03 First Reported 1986 Last Reported 1992 Negated 0 Speculated 0 Reported most in Title Documents 3 Total Number 4 Disease Relevance 1.10 Pain Relevance 1.25

extracellular region (CCBE1)

Anatomy Link Frequency CSF 3 plasma 1 CCBE1 (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 8 99.98 cva 4 96.04 Analgesic 1 93.00 agonist 2 91.88 Neuropeptide 2 90.08 anesthesia 1 75.00 epidural 1 54.80

Disease Link Frequency Relevance Heat Cv General 3 Under Development 1 96.04 Rupture 2 93.24 Cerebral Aneurysm 1 92.20 Aneurism 1 87.44 Lumbar Puncture Related Headaches 5 86.76 Cv General 4 Under Development 2 84.92 Subarachnoid Hemorrhage 1 75.00 Vascular Malformations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The possibility that the intravenous infusion of acetorphan, a prodrug of thiorphan (26 micrograms/kg per min for 60 min), can inhibit plasma and cerebrospinal fluid (CSF) enkephalinase in man in vivo was investigated.

Negative_regulation (inhibit) of cerebrospinal fluid in CSF

1) Confidence 0.03 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3015640 Disease Relevance 0 Pain Relevance 0.09

Loss of cerebrospinal fluid (CSF) from the puncture site with a subsequent decrease in CSF pressure and an increase in transmural wall tension of the vessels might be predisposing factors for the rupture of a pre-existing cerebral aneurysm.

Negative_regulation (Loss) of cerebrospinal fluid in CSF associated with cerebral aneurysm and rupture

2) Confidence 0.03 Published 1992 Journal Anaesthesist Section Abstract Doc Link 1570889 Disease Relevance 0.77 Pain Relevance 0.27

Clonidine decreases plasma and cerebrospinal fluid arginine vasopressin but not oxytocin in humans.

Negative_regulation (decreases) of cerebrospinal fluid in cerebrospinal fluid associated with clonidine

3) Confidence 0.01 Published 1987 Journal Neuroendocrinology Section Title Doc Link 3431654 Disease Relevance 0.17 Pain Relevance 0.44

Clonidine decreases plasma and cerebrospinal fluid arginine vasopressin but not oxytocin in humans.

Negative_regulation (decreases) of cerebrospinal fluid in plasma associated with clonidine

4) Confidence 0.00 Published 1987 Journal Neuroendocrinology Section Title Doc Link 3431654 Disease Relevance 0.17 Pain Relevance 0.44

General Comments

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