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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 6.55
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cd86)
Anatomy Link Frequency
CD86 7
dendrites 2
lymph nodes 1
DCs 1
blood 1
Cd86 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 186 99.36 Very High Very High Very High
Peripheral nerve injury 2 97.72 Very High Very High Very High
Neuropathic pain 2 95.32 Very High Very High Very High
Pyramidal cell 116 94.76 High High
Hippocampus 49 91.08 High High
Central nervous system 12 90.20 High High
Inflammation 69 90.04 High High
imagery 184 85.24 High High
tolerance 4 83.44 Quite High
cytokine 48 75.28 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

184 99.36 Very High Very High Very High
Stress 230 98.84 Very High Very High Very High
Nervous System Injury 2 97.28 Very High Very High Very High
Cancer 351 96.66 Very High Very High Very High
Neuropathic Pain 3 95.32 Very High Very High Very High
Glioma 136 95.20 Very High Very High Very High
INFLAMMATION 72 90.04 High High
Necrosis 23 87.96 High High
Cv General 3 Under Development 16 82.28 Quite High
Autism 1 81.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain.
Gene_expression (Presence) of CD86 in peripheral nerve associated with nervous system injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.57 Published 2004 Journal J. Neuroimmunol. Section Title Doc Link 14698851 Disease Relevance 0.36 Pain Relevance 0.47
In addition, the slight but significant difference in the over expression of IgG and alpha4beta7, together with the increased expression of CD80 and CD86, suggests that IBS patients also have increased B cell activation in the extra-intestinal lymph nodes.52 In order to explain this cellular infiltrate, Ohman and Simrén47 suggested 2 possible explanations: (1) It could be due to an unregulated mild inflammation or (2) It can reflect a potent inflammatory suppressive process led by activated T lymphocytes.
Gene_expression (expression) of CD86 in lymph nodes associated with inflammation and spastic colon
2) Confidence 0.39 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.36 Pain Relevance 0.64
The same group52 also described a state of B cell activation, finding increased CD80 and CD86 expression, at least in a subpopulation of IBS patients.
Gene_expression (expression) of CD86 in B cell associated with spastic colon
3) Confidence 0.39 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.27 Pain Relevance 0.50
Blood LDL-C before treatment was positively related to the expression of CD86.
Gene_expression (expression) of CD86 in CD86
4) Confidence 0.28 Published 2004 Journal Zhonghua Nei Ke Za Zhi Section Body Doc Link 15312437 Disease Relevance 0.11 Pain Relevance 0
RESULTS: When compared with normal group, CD86 on DC was much more expressed in UAP patients; the stimulating capacity of DC in MLR was higher; T lymphocytes in MLR secreted higher levels of pro-inflammation cytokines (IL-1beta, IL-6 and TNF-alpha) and lower level of anti-inflammation cytokine (IL-10).
Gene_expression (expressed) of CD86 in CD86
5) Confidence 0.28 Published 2004 Journal Zhonghua Nei Ke Za Zhi Section Body Doc Link 15312437 Disease Relevance 0.13 Pain Relevance 0
Relationship of expression of CD86 to risk factors and blood CRP level was also analyzed.
Gene_expression (expression) of CD86 in blood
6) Confidence 0.28 Published 2004 Journal Zhonghua Nei Ke Za Zhi Section Body Doc Link 15312437 Disease Relevance 0.14 Pain Relevance 0
Phenotypical expression of the generated DCs were analyzed to determine the expression level of CD14, CD86, CD83 and HLA-DR.
Spec (determine) Gene_expression (expression) of CD86 in DCs
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2829084 Disease Relevance 0.94 Pain Relevance 0.11
Expression markers specific for dendritic cells (such as CD14, CD86, CD83 and HLA-DR) were assessed by flow cytometry before and after addition of TNF- ?.


Gene_expression (Expression) of CD86 in CD86
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.14 Pain Relevance 0.04
Flow cytometric analysis was used to detect the expression of co-stimulating factor CD86 (B7-2) on DC.
Gene_expression (expression) of CD86 in CD86
9) Confidence 0.22 Published 2004 Journal Zhonghua Nei Ke Za Zhi Section Body Doc Link 15312437 Disease Relevance 0.16 Pain Relevance 0
After 4 days of incubation this media, expression of CD14 was down-regulated from 100% to 0.06%, whereas the expression of CD86 immature DC marker was up-regulated (from 56.95±13.82 to 77.95±3.59%).
Gene_expression (expression) of CD86 in CD86
10) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.56 Pain Relevance 0.11
It was recently found that LSEC constitutively express all molecules necessary for antigen presentation: CD54, CD80, CD86, MHC class I and II, and CD40, and can function as antigen-presenting cells for CD4+ and CD8+ T cells [67,68].
Gene_expression (express) of CD86 in CD86
11) Confidence 0.16 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.17 Pain Relevance 0.14
At day 5, U-251 tumor cell lysate was added to the generated immature DCs and by day 6, cell started exhibiting morphological changes that were accompanied with the further changes in the expression of DCs' phenotypical markers such as CD83, CD86, HLA-DR (Figure 1, Supplemental material, Table S1).
Gene_expression (expression) of CD86 in CD86 associated with cancer
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.49 Pain Relevance 0.10
Expression of the Axonal Membrane Glycoprotein M6a Is Regulated by Chronic Stress

It has been repeatedly shown that chronic stress changes dendrites, spines and modulates expression of synaptic molecules.

Gene_expression (Expression) of Membrane Glycoprotein in spines associated with stress
13) Confidence 0.07 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2629568 Disease Relevance 0.49 Pain Relevance 0.06
However, in a previous publication we showed that the membrane glycoprotein is not present in dendrites, but only in axons of glutamatergic neurons [6].
Neg (not) Gene_expression (present) of membrane glycoprotein in dendrites
14) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.29 Pain Relevance 0.07
Since the membrane glycoprotein is in particular strongly expressed in the mossy fibers one has to assume that stress changes the integrity of those axonal projections from the granule cells to CA3 pyramidal neurons.
Gene_expression (expressed) of membrane glycoprotein in pyramidal neurons associated with stress and pyramidal cell
15) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.34 Pain Relevance 0.33
Expression of the Axonal Membrane Glycoprotein M6a Is Regulated by Chronic Stress

It has been repeatedly shown that chronic stress changes dendrites, spines and modulates expression of synaptic molecules.

Gene_expression (Expression) of Membrane Glycoprotein in dendrites associated with stress
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2629568 Disease Relevance 0.49 Pain Relevance 0.06
DPP6 is a type II membrane glycoprotein expressed predominantly in the CNS.
Gene_expression (expressed) of membrane glycoprotein
17) Confidence 0.01 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0.31 Pain Relevance 0

General Comments

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