INT11565

From wiki-pain
Revision as of 15:13, 20 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 5.89
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tf) mitochondrion (Tf) extracellular space (Tf)
extracellular region (Tf) cytoplasmic membrane-bounded vesicle (Tf)
Anatomy Link Frequency
plasma 5
liver 3
mesencephalon 3
lymphocytes 2
hepatocyte 1
Tf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 56 99.72 Very High Very High Very High
halothane 45 99.54 Very High Very High Very High
Central grey 15 98.04 Very High Very High Very High
Morphine 18 97.00 Very High Very High Very High
Dopamine 69 92.28 High High
Neuropathic pain 6 85.88 High High
Central nervous system 44 83.60 Quite High
Glutamate 9 82.64 Quite High
diabetic neuropathy 4 81.80 Quite High
Kinase C 10 80.64 Quite High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 89 99.58 Very High Very High Very High
Cancer 109 98.32 Very High Very High Very High
Urological Neuroanatomy 18 98.04 Very High Very High Very High
Generalized Anxiety Disorder 2 97.86 Very High Very High Very High
Stress 46 96.72 Very High Very High Very High
Apoptosis 67 96.28 Very High Very High Very High
Sepsis 11 96.20 Very High Very High Very High
Malignant Neoplastic Disease 3 95.32 Very High Very High Very High
Nervous System Injury 10 92.64 High High
Injury 134 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Halothane decreases albumin and transferrin synthesis: studies in the isolated, perfused rat liver and in the intact rat.
Gene_expression (synthesis) of transferrin in liver associated with halothane
1) Confidence 0.68 Published 1988 Journal Anesthesiology Section Title Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.54
Isolated perfused rat livers exposed to 1.5% halothane (equivalent to 1.35 MAC) in O2/CO2 or to O2/CO2 alone produced urea, as well as albumin and transferrin (both measured by immunodiffusion), at constant rates during a 4.25-h perfusion.
Gene_expression (produced) of transferrin in livers associated with halothane
2) Confidence 0.68 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.31
Reduced GSH levels and the ceruloplasmin/transferrin ratio were determined as measures of overall antioxidant activity.
Gene_expression (ratio) of transferrin
3) Confidence 0.62 Published 2009 Journal J. Surg. Res. Section Body Doc Link 18708193 Disease Relevance 0.09 Pain Relevance 0
Urea production did not differ in the two treatment groups, but halothane depressed albumin and transferrin synthesis 43% and 45%, respectively.
Gene_expression (synthesis) of transferrin associated with halothane
4) Confidence 0.59 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.51
Using electron paramagnetic resonance spectroscopy, we also determined plasma levels of transferrin and ceruloplasmin.
Spec (determined) Gene_expression (levels) of transferrin in plasma
5) Confidence 0.55 Published 2009 Journal J. Surg. Res. Section Body Doc Link 18708193 Disease Relevance 0.08 Pain Relevance 0
Under these culture conditions, albumin and transferrin secreted in vitro by adult rat hepatocyte spheroids were detectable by immunoprecipitation method at least until 2 months of culture.
Gene_expression (detectable) of transferrin in hepatocyte
6) Confidence 0.38 Published 1992 Journal Exp. Cell Res. Section Abstract Doc Link 1572400 Disease Relevance 0 Pain Relevance 0.10
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Gene_expression (expression) of transferrin in mesencephalon associated with central grey and morphine
7) Confidence 0.27 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.60
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Gene_expression (expression) of transferrin in mesencephalon associated with central grey and morphine
8) Confidence 0.27 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.60
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Gene_expression (expression) of transferrin in mesencephalon associated with central grey and morphine
9) Confidence 0.24 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.60
Abnormal expression of Tfn/TfnR results in an unbalanced iron homeostasis that is associated with oxidative stress and programmed cell death [10] which has been well documented in HT29 cells treated with flavone [11], or tangutorine [12].
Gene_expression (expression) of Tfn associated with stress and apoptosis
10) Confidence 0.17 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.88 Pain Relevance 0.05
In the liver, the rate of synthesis of selected proteins (i.e., albumin, transferrin, prealbumin, retinol-binding protein, and fibronectin) is decreased, whereas acute phase protein synthesis is accelerated [94].
Gene_expression (synthesis) of transferrin in liver
11) Confidence 0.13 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 1.16 Pain Relevance 0.15
TfnR is up-regulated in cancer cells for enhancing iron uptake, and iron depletion by iron chelators or decreased expression of Tfn and TfnR have been proven to be effective in the treatment of cancer [10,21].
Gene_expression (expression) of Tfn associated with cancer
12) Confidence 0.13 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.38 Pain Relevance 0
The increase of cellular iron uptake is associated with an increased expression of iron import proteins, such as Tfn and TfnR [21].
Gene_expression (expression) of Tfn
13) Confidence 0.13 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.44 Pain Relevance 0
The role of the transferrin and B-cell receptors being differentially expressed in the axotomized facial nucleus [33] or red nucleus respectively, remains unclear.
Gene_expression (expressed) of transferrin in nucleus
14) Confidence 0.12 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0.13 Pain Relevance 0.08
The differential expression of transferrin receptor, P4-kinase, STAT-5 and connexin-43 confirm already published studies from other research groups [16,33-35].
Gene_expression (expression) of transferrin
15) Confidence 0.09 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0 Pain Relevance 0
Our data suggest that insulin may reduce 5-HT2C receptor activity, thereby increasing CSF production and decreasing transferrin production.
Gene_expression (production) of transferrin
16) Confidence 0.07 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.07
Laboratory assessment of serum albumin, prealbumin, retinol-binding protein, and transferrin levels; cutaneous anergy testing of immune responsiveness and total lymphocyte count; and physical determinants like triceps skin fold measurement and lean body mass may be utilized and followed clinically.113 If these indicators are abnormal prior to surgical intervention, a nutritional support protocol is strongly recommended preoperatively to facilitate postoperative wound healing and minimize wound complications.114 Ultimately, the goal of preoperative support is to allow adequate protein synthesis postoperatively.115
Gene_expression (levels) of transferrin in lymphocyte associated with injury and wound healing
17) Confidence 0.05 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.33 Pain Relevance 0.03
For example, upon intraventricular injection, 5-HT2C agonists decrease the production of CSF [44] and in primary cultures of choroid plexus, 5-HT agonists increase the expression of transferrin [45,46], an iron carrier protein which has trophic effects on the brain.
Gene_expression (expression) of transferrin in choroid plexus associated with agonist
18) Confidence 0.05 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.10
To detect transferrin and albumin in equine plasma rabbit anti-equine transferrin and rabbit anti-equine albumin antibodies (Bethyl Laboratories, Cambridge, UK) were used respectively.
Gene_expression (used) of transferrin in plasma
19) Confidence 0.03 Published 2008 Journal BMC Vet Res Section Body Doc Link PMC2527303 Disease Relevance 0 Pain Relevance 0.07
To detect transferrin and albumin in equine plasma rabbit anti-equine transferrin and rabbit anti-equine albumin antibodies (Bethyl Laboratories, Cambridge, UK) were used respectively.
Gene_expression (detect) of transferrin in plasma
20) Confidence 0.03 Published 2008 Journal BMC Vet Res Section Body Doc Link PMC2527303 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox