INT115674

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 1.22
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
cerebral cortex 1
neurites 1
hippocampus 1
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 4 100.00 Very High Very High Very High
Hippocampus 4 100.00 Very High Very High Very High
antidepressant 8 93.44 High High
fluoxetine 4 92.92 High High
Nerve growth factor 85 92.76 High High
Desipramine 2 88.76 High High
Neurotransmitter 29 75.00 Quite High
depression 2 72.28 Quite High
anesthesia 5 60.60 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 15 94.12 High High
Increased Venous Pressure Under Development 20 92.28 High High
Neuroblastoma 15 84.36 Quite High
Fasciculation 5 80.32 Quite High
Cancer 10 74.04 Quite High
Depression 2 72.28 Quite High
Metastasis 5 71.44 Quite High
Injury 5 24.56 Low Low
Death 5 22.48 Low Low
Apoptosis 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, synapsin I-mRNA levels in the hippocampus and cerebral cortex are significantly reduced in tranylcypromine-treated animals.
Negative_regulation (reduced) of synapsin I-mRNA in cerebral cortex associated with hippocampus and cerebral cortex
1) Confidence 0.41 Published 2004 Journal Pharmacogenomics J. Section Abstract Doc Link 14708000 Disease Relevance 0.07 Pain Relevance 0.69
Additionally, synapsin I-mRNA levels in the hippocampus and cerebral cortex are significantly reduced in tranylcypromine-treated animals.
Negative_regulation (reduced) of synapsin I-mRNA in hippocampus associated with hippocampus and cerebral cortex
2) Confidence 0.14 Published 2004 Journal Pharmacogenomics J. Section Abstract Doc Link 14708000 Disease Relevance 0.07 Pain Relevance 0.69
We showed that a decreased Syn-1 level led to a decrease in the number of neurites and the percentage of branch-bearing neurites.
Negative_regulation (decreased) of Syn-1 in neurites
3) Confidence 0.13 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.31 Pain Relevance 0.12
This shRNA effectively reduced the endogenous level of Syn-1.
Negative_regulation (reduced) of Syn-1
4) Confidence 0.10 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.31 Pain Relevance 0.12
The mechanism of the downregulation of MafK, SytI, and Syn-1 genes by Akt remains unclear.
Negative_regulation (downregulation) of Syn-1
5) Confidence 0.10 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.31 Pain Relevance 0.04
Target sequences for knockdown of Syn-1 were: shSyn-1#1 (GGATTAGGAGAGCAGAGAT), shSyn-1#2 (GTGAGATCAACGGACAGAA).
Negative_regulation (knockdown) of Syn-1
6) Confidence 0.10 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.09 Pain Relevance 0.13
Effect of an Akt-specific inhibitor on expression of MafK, SytI, and Syn-1 genes in PC12 (WT-Akt) cells
Negative_regulation (inhibitor) of Syn-1
7) Confidence 0.04 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.05 Pain Relevance 0

General Comments

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