INT115677

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 4.69
Pain Relevance 6.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Syp)
Anatomy Link Frequency
cerebral cortex 6
synapses 4
telencephalon 2
medial 2
brain 2
Syp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 592 99.84 Very High Very High Very High
antidepressant 22 99.78 Very High Very High Very High
fluoxetine 12 99.78 Very High Very High Very High
Peripheral nerve injury 2 99.08 Very High Very High Very High
Hippocampus 74 97.60 Very High Very High Very High
cerebral cortex 20 96.96 Very High Very High Very High
Desipramine 4 95.00 High High
Thalamus 48 91.00 High High
Calcitonin gene-related peptide 1 84.28 Quite High
depression 6 84.00 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 304 99.48 Very High Very High Very High
Nervous System Injury 2 98.64 Very High Very High Very High
Targeted Disruption 9 98.24 Very High Very High Very High
Adhesions 2 95.72 Very High Very High Very High
Stroke 90 94.52 High High
Shock 84 92.24 High High
Injury 10 88.40 High High
Depression 6 84.00 Quite High
Middle Cerebral Artery Infarction 48 83.52 Quite High
Ganglion Cysts 4 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results demonstrate that chronic treatment with fluoxetine and tranylcypromine leads to an increased expression of synaptophysin, but decreased expression of synaptotagmin and VAMP in the hippocampus and cerebral cortex.
Positive_regulation (increased) of Gene_expression (expression) of synaptophysin in cerebral cortex associated with hippocampus, cerebral cortex and fluoxetine
1) Confidence 0.63 Published 2004 Journal Pharmacogenomics J. Section Abstract Doc Link 14708000 Disease Relevance 0.08 Pain Relevance 0.70
The results demonstrate that chronic treatment with fluoxetine and tranylcypromine leads to an increased expression of synaptophysin, but decreased expression of synaptotagmin and VAMP in the hippocampus and cerebral cortex.
Positive_regulation (leads) of Gene_expression (expression) of synaptophysin in cerebral cortex associated with hippocampus, cerebral cortex and fluoxetine
2) Confidence 0.63 Published 2004 Journal Pharmacogenomics J. Section Abstract Doc Link 14708000 Disease Relevance 0.08 Pain Relevance 0.70
Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon.
Positive_regulation (induces) of Gene_expression (expression) of synaptophysin in telencephalon associated with antidepressant
3) Confidence 0.55 Published 2007 Journal Eur Neuropsychopharmacol Section Title Doc Link 17307340 Disease Relevance 0.15 Pain Relevance 0.45
Finally, a recent study has shown that fear conditioning leads to an increase in the expression of the presynaptically- localized protein synaptophysin at LA synapses [31].
Positive_regulation (increase) of Gene_expression (expression) of synaptophysin in synapses associated with anxiety disorder and amygdala
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.59 Pain Relevance 0.55
Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury.
Positive_regulation (up-regulation) of Gene_expression (expression) of synaptophysin in primary sensory neurons associated with nervous system injury and peripheral nerve injury
5) Confidence 0.49 Published 2006 Journal Neuroscience Section Title Doc Link 16777346 Disease Relevance 0.42 Pain Relevance 0.33
Chronic fluoxetine treatment increases synaptophysin and PSA-NCAM expression in the medial prefrontal cortex and decreases them in the amygdala.
Positive_regulation (increases) of Gene_expression (expression) of synaptophysin in medial associated with amygdala and fluoxetine
6) Confidence 0.40 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17307340 Disease Relevance 0.18 Pain Relevance 0.47
In the present study, increased expression of synaptophysin in the subcortical regions of the ischemic hemisphere may represent increased plastic changes in these regions.
Positive_regulation (increased) of Gene_expression (expression) of synaptophysin
7) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.22 Pain Relevance 0.26
In the present study, we show that auditory Pavlovian fear conditioning is associated with significant and persistent increases in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin and synaptophysin in the LA.
Positive_regulation (increases) of Gene_expression (expression) of synaptophysin associated with anxiety disorder and amygdala
8) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.37 Pain Relevance 0.33
Western blotting on tissue taken from the LA was performed to assay training-induced expression of GluR1, synapsin, and synaptophysin in the LA at each of the different time points.
Positive_regulation (induced) of Gene_expression (expression) of synaptophysin associated with amygdala
9) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.71 Pain Relevance 0.18
In support of this hypothesis, we have shown that intra-MGm/PIN infusion of a MEK inhibitor blocks synaptic plasticity in the LA [43] and, more recently, that intra-MGm/PIN infusion of an antisense oligodeoxynucleotide to EGR-1 impairs the training-induced expression of synapsin and synaptophysin at LA synapses [32].
Positive_regulation (induced) of Gene_expression (expression) of synaptophysin in synapses associated with amygdala
10) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.35 Pain Relevance 0.47
Low-intensity treadmill training might be insufficient to improve neurological and behavioral outcomes although such training induced the expression of brain synaptophysin.
Positive_regulation (induced) of Gene_expression (expression) of synaptophysin in brain
11) Confidence 0.34 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.42 Pain Relevance 0.06
However, synaptophysin expression was significantly higher in ischemic hemispheres than contralateral hemispheres only in the motor balance and coordination training group.
Positive_regulation (higher) of Gene_expression (expression) of synaptophysin
12) Confidence 0.26 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.17 Pain Relevance 0.17
Western blot analysis for BDNF and synaptophysin
Positive_regulation (for) of Gene_expression (analysis) of synaptophysin
13) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.07 Pain Relevance 0
The results demonstrate that chronic treatment with fluoxetine and tranylcypromine leads to an increased expression of synaptophysin, but decreased expression of synaptotagmin and VAMP in the hippocampus and cerebral cortex.
Positive_regulation (increased) of in hippocampus Gene_expression (expression) of synaptophysin in cerebral cortex associated with hippocampus, cerebral cortex and fluoxetine
14) Confidence 0.21 Published 2004 Journal Pharmacogenomics J. Section Abstract Doc Link 14708000 Disease Relevance 0.08 Pain Relevance 0.70
The results demonstrate that chronic treatment with fluoxetine and tranylcypromine leads to an increased expression of synaptophysin, but decreased expression of synaptotagmin and VAMP in the hippocampus and cerebral cortex.
Positive_regulation (leads) of in hippocampus Gene_expression (expression) of synaptophysin in cerebral cortex associated with hippocampus, cerebral cortex and fluoxetine
15) Confidence 0.21 Published 2004 Journal Pharmacogenomics J. Section Abstract Doc Link 14708000 Disease Relevance 0.08 Pain Relevance 0.70
In addition, treatment using statin that induces BDNF up-regulation is linked to an increase in synaptophysin expression and to a significant improvement in functional recovery [55].
Positive_regulation (increase) of Gene_expression (expression) of synaptophysin
16) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.23 Pain Relevance 0.03
Consistently, blocking BDNF action abrogates exercice-induced synaptophysin expression [70].
Positive_regulation (induced) of Gene_expression (expression) of synaptophysin
17) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.29 Pain Relevance 0.03
In 3-AB treated animals, the increase in synaptophysin expression was abrogated in both P1 and P2 cortical samples.
Positive_regulation (increase) of Gene_expression (expression) of synaptophysin
18) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.21 Pain Relevance 0.10

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