INT115753

Context Info Confidence 0.38 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0 Pain Relevance 0.44

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)

Nav1 (Mus musculus)

Pain Link Frequency Relevance Heat tetrodotoxin 3 84.48 addiction 1 81.48 sodium channel 6 75.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In med cells, the resurgent component of beta-PMTX-modified sodium currents could be selectively abolished by application of intracellular alkaline phosphatase, suggesting that, like in NaV1.6-expressing cells, the open-channel block of NaV1.1 and NaV1.2 subunits is regulated by constitutive phosphorylation.

Regulation (regulated) of Negative_regulation (block) of NaV1

1) Confidence 0.38 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14715935 Disease Relevance 0 Pain Relevance 0.16

In med cells, the resurgent component of beta-PMTX-modified sodium currents could be selectively abolished by application of intracellular alkaline phosphatase, suggesting that, like in NaV1.6-expressing cells, the open-channel block of NaV1.1 and NaV1.2 subunits is regulated by constitutive phosphorylation.

Regulation (regulated) of Negative_regulation (block) of NaV1

2) Confidence 0.38 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14715935 Disease Relevance 0 Pain Relevance 0.16

In this 'neonatal K211D' mutant, the electrophysiological parameters studied strongly shifted back towards the 'adult', that is the lysine residue was primarily responsible for the electrophysiological effects of Nav1.5 D1:S3 splicing.

Regulation (responsible) of Negative_regulation (effects) of Nav1

3) Confidence 0.15 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18393272 Disease Relevance 0 Pain Relevance 0.13

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