INT115853

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.72
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
neurons 3
nerve 2
gut 2
Sensory neurons 1
spinal nerve 1
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 6 100.00 Very High Very High Very High
nociceptor 16 99.44 Very High Very High Very High
imagery 38 97.36 Very High Very High Very High
Pain 148 96.64 Very High Very High Very High
qutenza 20 95.98 Very High Very High Very High
allodynia 147 95.36 Very High Very High Very High
TRP channel 50 93.12 High High
calcitonin gene related peptide 30 92.36 High High
agonist 50 89.92 High High
dorsal root ganglion 21 88.96 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 125 99.72 Very High Very High Very High
Nociception 86 99.52 Very High Very High Very High
Reprotox - General 1 94 99.20 Very High Very High Very High
Injury 339 99.04 Very High Very High Very High
Pain 159 96.64 Very High Very High Very High
Metastasis 5 96.32 Very High Very High Very High
Neuropathic Pain 312 95.36 Very High Very High Very High
Ganglion Cysts 35 88.96 High High
Targeted Disruption 28 87.68 High High
Sprains And Strains 129 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L5 spinal nerve injury did not change the level of Trpm8 mRNA expression in the L4DRG.


Transcription (expression) of Trpm8 in spinal nerve associated with nervous system injury
1) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.96 Pain Relevance 0.35
Responses to capsaicin, menthol, and cinnamaldehyde were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected.
Transcription (detected) of TRPM8 associated with qutenza and member 8
2) Confidence 0.68 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344381 Disease Relevance 0.27 Pain Relevance 0.66
Sensory neurons derived from TRPM8-null mice lack detectable levels of TRPM8 mRNA and protein and their number responding to cold (18°C) and menthol (100 mM) is greatly reduced [14].
Transcription (levels) of TRPM8 in Sensory neurons
3) Confidence 0.68 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.08
We detected TRPM8 mRNA in approximately 7% of neurons within the DRG.
Transcription (detected) of TRPM8 in neurons
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.57 Pain Relevance 0.39
In addition, RT-PCR of single nodose cell bodies, which had been retrogradely labeled from the upper gut, detected transcripts for TRPV1, TRPV2, TRPV4, TRPN1, and TRPM8 in a proportion of cells.
Transcription (detected) of TRPM8 in gut
5) Confidence 0.64 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14726308 Disease Relevance 0.16 Pain Relevance 0.35
Distribution of TRPM8 and TRPA1 mRNA after nerve injury
Transcription (Distribution) of TRPM8 in nerve associated with nervous system injury
6) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.77 Pain Relevance 0.33
TRPM8 and TRPA1 expression levels after nerve injury
Transcription (levels) of TRPM8 in nerve associated with nervous system injury
7) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.36 Pain Relevance 0.45
However, similar to TRPM8 and TRPA1, this mRNA was also expressed at a lower level after injury (Fig. 2d).
Transcription (expressed) of TRPM8 associated with injury
8) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.87 Pain Relevance 0.16
We detected a relatively low level of mRNA for TRPM8 and TRPA1 in the DRG of control mice (TRPM8, 106400 copies/µg total RNA, TRPA1, 280900 copies/µg RNA) which correlates well with the selective expression of these channels within small subpopulations of neurons.
Transcription (detected) of TRPM8 in neurons
9) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.04 Pain Relevance 0.30
Here, we show that sensory neurons derived from TRPM8 null mice lack detectable levels of TRPM8 mRNA and protein and that the number of these neurons responding to cold (18 degrees C) and menthol (100 microM) is greatly decreased.
Transcription (levels) of TRPM8 in neurons
10) Confidence 0.53 Published 2007 Journal Neuron Section Abstract Doc Link 17481392 Disease Relevance 0.17 Pain Relevance 0.16
In contrast to TRPA1, the cold-sensitivity of TRPM8 is well-established.
Transcription (sensitivity) of TRPM8
11) Confidence 0.53 Published 2007 Journal Mol Pain Section Body Doc Link PMC1988789 Disease Relevance 0.25 Pain Relevance 0.14
In addition, RT-PCR of single nodose cell bodies, which had been retrogradely labeled from the upper gut, detected transcripts for TRPV1, TRPV2, TRPV4, TRPN1, and TRPM8 in a proportion of cells.
Transcription (transcripts) of TRPM8 in gut
12) Confidence 0.48 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14726308 Disease Relevance 0.16 Pain Relevance 0.35
TRPM8 mRNA was not detected.
Neg (not) Transcription (detected) of TRPM8
13) Confidence 0.34 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.24 Pain Relevance 0.13
Expression profiles of genes in CRPC support a role for the transcriptional activity of the androgen receptor (CCNH, CUEDC2, FLNA, PSMA7), steroid synthesis and metabolism (DHCR24, DHRS7, ELOVL5, HSD17B4, OPRK1), neuroendocrine (ENO2, MAOA, OPRK1, S100A10, TRPM8), and proliferation (GAS5, GNB2L1, MT-ND3, NKX3-1, PCGEM1, PTGFR, STEAP1, TMEM30A), but neither supported nor discounted a role for cell survival genes.


Transcription (activity) of TRPM8 in ND3 associated with reprotox - general 1
14) Confidence 0.20 Published 2010 Journal BMC Med Genomics Section Abstract Doc Link PMC2956710 Disease Relevance 0.83 Pain Relevance 0
Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin challenge.
Transcription (expression) of receptor potential in inner ear associated with member 8
15) Confidence 0.06 Published 2005 Journal Hear. Res. Section Title Doc Link 15721568 Disease Relevance 0.06 Pain Relevance 0.27

General Comments

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