INT1159

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2011
Negated 2
Speculated 5
Reported most in Abstract
Documents 133
Total Number 138
Disease Relevance 40.14
Pain Relevance 31.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
blood 16
plasma 15
heart 5
PVN 4
kidney 4
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 115 100.00 Very High Very High Very High
antagonist 101 100.00 Very High Very High Very High
Enkephalin 59 100.00 Very High Very High Very High
Catecholamine 35 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
Intracerebroventricular 15 99.98 Very High Very High Very High
Analgesic 3 99.98 Very High Very High Very High
Central nervous system 8 99.92 Very High Very High Very High
noradrenaline 16 99.90 Very High Very High Very High
bradykinin 36 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 632 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 92 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 5 100.00 Very High Very High Very High
Heart Rate Under Development 49 99.92 Very High Very High Very High
Hypotension 31 99.90 Very High Very High Very High
Natriuresis 16 99.76 Very High Very High Very High
Ganglion Cysts 3 99.42 Very High Very High Very High
Pain 18 99.40 Very High Very High Very High
Papillomavirus Infection 4 99.24 Very High Very High Very High
Nociception 3 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enalaprilat resulted in a significant increase in plasma Ang I from 133+/-21 to 1167+/-328 pmol/L and a decrease in plasma Ang II from 110+/-12 to 67+/-9 pmol/L.
Negative_regulation (decrease) of Ang II in plasma
1) Confidence 0.59 Published 2002 Journal Hypertension Section Abstract Doc Link 11799091 Disease Relevance 0.07 Pain Relevance 0
Assessment of angiotensin II binding sites in the solitary-vagal complex 24 hours after denervation showed a 13% reduction in angiotensin receptors.
Negative_regulation (reduction) of angiotensin
2) Confidence 0.58 Published 1990 Journal Hypertension Section Abstract Doc Link 2298474 Disease Relevance 0.14 Pain Relevance 0.17
Collectively, the data suggest that opiates do not alter peripheral beta-adrenergic responses and that the blocking effects of naloxone on the isoproterenol-induced drinking response is mediated centrally and may be due to blocking angiotensin II dipsogenesis.
Negative_regulation (blocking) of angiotensin II associated with narcan and opiate
3) Confidence 0.58 Published 1990 Journal Pharmacology Section Abstract Doc Link 2277811 Disease Relevance 0 Pain Relevance 0.45
These results indicate that the antidepressant drugs reduced the activity of angiotensin II, albeit non-selectively, and suggest that the previously reported effects of antidepressants on isoprenaline-induced drinking in rats reflect an action on angiotensin activity rather than a reduction of beta-adrenoceptor activity as previously suggested.
Negative_regulation (reduced) of angiotensin associated with antidepressant
4) Confidence 0.58 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7698168 Disease Relevance 0 Pain Relevance 0.45
Reduction of angiotensin II concentrations in plasma and kidney following angiotensin-converting enzyme inhibition also reduces proteinuria, not only in nephrotic conditions but also in diverse diseases, including diabetes mellitus, glomerulosclerosis following subtotal nephrectomy, and membranous nephropathy.
Negative_regulation (Reduction) of angiotensin II in kidney associated with membranous glomerulonephritis, diabetes mellitus, proteinuria and disease
5) Confidence 0.57 Published 1990 Journal Nephron Section Abstract Doc Link 2111884 Disease Relevance 0.88 Pain Relevance 0.09
Therapeutic approaches to the treatment of catecholamine-induced heart failure may be potassium and magnesium supplements and possibly drugs reducing circulating angiotensin II activities.
Negative_regulation (reducing) of angiotensin II in heart associated with catecholamine and myocardial infarction
6) Confidence 0.57 Published 1985 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 4036531 Disease Relevance 0.52 Pain Relevance 0.13
The radioactive microsphere technique was used to investigate the distribution of blood flow during halothane anesthesia when either sodium nitroprusside (SNP) or saralasin, a competitive inhibitor of angiotensin II, was infused.
Negative_regulation (inhibitor) of angiotensin II in blood associated with anesthesia and halothane
7) Confidence 0.56 Published 1981 Journal Anesthesiology Section Abstract Doc Link 7469102 Disease Relevance 0 Pain Relevance 0.19
The protocol consisted of a 1-h control awake period, 1 h of stable anesthesia (one group received no anesthesia), and 30-min iv infusion of saralasin, a competitive inhibitor of angiotensin II.
Negative_regulation (inhibitor) of angiotensin II associated with anesthesia
8) Confidence 0.56 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6424515 Disease Relevance 0.16 Pain Relevance 0.68
Zoletil anesthesia did not interfere with the effects of angiotensin II, AT1, AT2 antagonists, or nitric oxide synthetase inhibitors.
Negative_regulation (inhibitors) of angiotensin II
9) Confidence 0.55 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17959957 Disease Relevance 0 Pain Relevance 0
Plasma renin activity was decreased below detectable limits, but plasma angiotensin II concentrations were not reduced.
Neg (not) Negative_regulation (reduced) of angiotensin II in Plasma
10) Confidence 0.52 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.33 Pain Relevance 0
A second group of rats was treated identically and, in addition, received an infusion of saralasin (a competitive inhibitor of angiotensin II) throughout the experimental period.
Negative_regulation (inhibitor) of angiotensin II
11) Confidence 0.52 Published 1980 Journal Anesthesiology Section Abstract Doc Link 7352670 Disease Relevance 0.34 Pain Relevance 0.35
In rats on a low sodium diet treated chronically with enalapril, CP71362 did not further decrease blood pressure although angiotensin II levels were significantly reduced.
Negative_regulation (reduced) of angiotensin II in blood
12) Confidence 0.52 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.32 Pain Relevance 0
The suppression of plasma ANG II thus explains a minor part of the acute reduction of MABP by captopril in WKY and a major part of this action in SHR.
Negative_regulation (suppression) of ANG II in plasma associated with hypertension
13) Confidence 0.51 Published 1986 Journal J. Hypertens. Section Abstract Doc Link 3514745 Disease Relevance 0.70 Pain Relevance 0
In addition, Mineo et al., [27] reported a similar 50% inhibition of 125I-Ang II in the presence of unlabeled Ang II in endothelial cell monolayers.
Negative_regulation (inhibition) of 125I-Ang II in endothelial cell
14) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.33 Pain Relevance 0
These results indicated that either decrease of Ang II or blockage of AT1 receptor in the PVN normalized the enhanced CSAR evoked by epicardial application of BK in rats with CHF, and that increased expression of AT1 receptor in the PVN contributed to the enhanced CSAR in the CHF state.
Negative_regulation (decrease) of Ang II in PVN associated with myocardial infarction
15) Confidence 0.50 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 16099221 Disease Relevance 0.70 Pain Relevance 0.15
Renal angiotensin II and III were further suppressed during dietary salt supplementation in both salt-resistant strains but not in the spontaneously hypertensive rat.
Neg (not) Negative_regulation (suppressed) of angiotensin II associated with hypertension and sprains and strains
16) Confidence 0.49 Published 1995 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 8589288 Disease Relevance 0.47 Pain Relevance 0.06
An additive effect of combined converting enzyme and renin inhibition on blood pressure lowering and inhibition of plasma angiotensin II was found in rats anesthetized with Inactin.
Negative_regulation (inhibition) of angiotensin II in blood associated with hypotension
17) Confidence 0.45 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.31 Pain Relevance 0
Tempol prevented an Ang II dependent decrease in medullary (but not cortical) NO without affecting RBF or IMBF responses.
Negative_regulation (decrease) of Ang II
18) Confidence 0.43 Published 2004 Journal Acta Physiol. Scand. Section Body Doc Link 15491410 Disease Relevance 0 Pain Relevance 0
Naloxone, administered to rats subcutaneously or by i.c.v. route, produces a dose-dependent inhibition of water intake elicited by angiotensin II or water deprivation.
Negative_regulation (deprivation) of angiotensin II associated with narcan
19) Confidence 0.43 Published 1982 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7092405 Disease Relevance 0 Pain Relevance 0.52
In summary, the present study demonstrated that rilmenidine decreases the hypertensive effect of ANG II, with more potency than clonidine, even when injected into 3rdV or PVN.
Negative_regulation (decreases) of ANG II in PVN associated with hypertension, clonidine and potency
20) Confidence 0.43 Published 1998 Journal J. Physiol. Paris Section Abstract Doc Link 9638593 Disease Relevance 0.27 Pain Relevance 0.48

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