INT115915

Context Info Confidence 0.06 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.36 Pain Relevance 0.43

immune system process (AHR) small molecule metabolic process (CYP2B6) cell morphogenesis (AHR) endoplasmic reticulum (CYP2B6) DNA binding (AHR) response to stress (AHR)

Anatomy Link Frequency 1A2 4 AHR (Homo sapiens) CYP2B6 (Homo sapiens)

Pain Link Frequency Relevance Heat Analgesic 4 81.76 antagonist 2 75.00 aspirin 6 74.00

Disease Link Frequency Relevance Heat Cancer 2 96.48 Hepatocellular Cancer 2 85.36 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The detrimental effects of TCDD are mediated via the aryl hydrocarbon receptor (AhR), a transcription factor that regulates the expression of the carcinogen-activating enzymes cytochromes P-450 (CYP) 1A1, 1A2, and 1B1.

AhR Regulation (regulates) of Gene_expression (expression) of cytochromes P-450 in 1A2

1) Confidence 0.06 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.18 Pain Relevance 0.22

The detrimental effects of TCDD are mediated via the aryl hydrocarbon receptor (AhR), a transcription factor that regulates the expression of the carcinogen-activating enzymes cytochromes P-450 (CYP) 1A1, 1A2, and 1B1.

aryl hydrocarbon receptor Regulation (regulates) of Gene_expression (expression) of cytochromes P-450 in 1A2

2) Confidence 0.06 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.18 Pain Relevance 0.22

General Comments

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