INT11604

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Context Info
Confidence 0.42
First Reported 1985
Last Reported 1995
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.62
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
plasma 2
somatotrophs 2
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 15 100.00 Very High Very High Very High
Somatostatin 7 100.00 Very High Very High Very High
Sumatriptan 10 99.82 Very High Very High Very High
Serotonin 2 75.00 Quite High
agonist 1 74.56 Quite High
Endogenous opioid 2 48.84 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 4 95.72 Very High Very High Very High
Obesity 2 89.04 High High
Adrenocortical Hyperfunction 2 83.76 Quite High
Immunization 1 74.72 Quite High
Growth Problems 1 54.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the mechanism of growth hormone autofeedback regulation: possible role of somatostatin and growth hormone-releasing factor.
Regulation (regulation) of Spec (possible) Positive_regulation (role) of growth hormone-releasing associated with somatostatin
1) Confidence 0.42 Published 1985 Journal Endocrinology Section Title Doc Link 2866085 Disease Relevance 0.07 Pain Relevance 0.65
The effects of clonidine, a growth hormone (GH) secretagogue, acting at the hypothalamic level and synthetic GH-releasing hormone (GHRH), a physiological stimulus of somatotrophs, on GH secretion were measured in 11 dogs with Cushing's syndrome.
Regulation (effects) of Positive_regulation (acting) of GH-releasing hormone in somatotrophs associated with syndrome and clonidine
2) Confidence 0.21 Published 1995 Journal Res. Vet. Sci. Section Abstract Doc Link 7761697 Disease Relevance 0.32 Pain Relevance 0.29
These data are compatible with the hypothesis that beta-endorphin levels affect the GH response to GHRH in prepubertal children, but have no discernible effect on the GH response to GHRH in pubertal children.
Regulation (affect) of Positive_regulation (response) of GHRH
3) Confidence 0.17 Published 1992 Journal Endocr. Res. Section Abstract Doc Link 1576976 Disease Relevance 0.05 Pain Relevance 0
The Sumatriptan-induced increase in GH responses to GHRH was dependent on the stimulus tested.
Regulation (dependent) of Positive_regulation (increase) of GHRH associated with sumatriptan
4) Confidence 0.15 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7775648 Disease Relevance 0.17 Pain Relevance 0.86
The effect of chronic administration of GH (8-24 months) on plasma GH responses to GHRH, clonidine and spontaneous GH secretion were studied in 17 NSD patients.
Regulation (effect) of Positive_regulation (responses) of GHRH in plasma associated with clonidine
5) Confidence 0.06 Published 1991 Journal Horm. Res. Section Abstract Doc Link 1806474 Disease Relevance 0 Pain Relevance 0.24

General Comments

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