INT11605

Context Info Confidence 0.45 First Reported 1987 Last Reported 2007 Negated 1 Speculated 2 Reported most in Abstract Documents 10 Total Number 12 Disease Relevance 2.08 Pain Relevance 3.85

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh) extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)

Anatomy Link Frequency plasma 8 Gh (Mus musculus)

Pain Link Frequency Relevance Heat Sumatriptan 21 100.00 fluoxetine 4 100.00 dexamethasone 4 100.00 narcan 6 99.82 Clonidine 10 99.60 noradrenaline 3 97.16 carpal tunnel syndrome 1 95.32 tolerance 3 92.40 Somatostatin 15 87.92 agonist 2 81.52

Disease Link Frequency Relevance Heat Carcinoid 20 97.28 Arthralgia 1 95.92 Hypertension 10 95.52 Carpal Tunnel Syndrome 1 95.32 Pressure And Volume Under Development 1 94.36 Aging 2 89.44 Obesity 2 89.04 Cancer 47 85.72 Adenoma 15 81.24 Acromegaly 19 75.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OBJECTIVE: The authors' objective was to characterize the effects of fluoxetine treatment on dexamethasone-induced growth hormone (GH) responses in depressed patients.

Regulation (effects) of Positive_regulation (dexamethasone-induced) of GH associated with dexamethasone and fluoxetine

1) Confidence 0.45 Published 1995 Journal Am J Psychiatry Section Abstract Doc Link 7694914 Disease Relevance 0.07 Pain Relevance 0.30

OBJECTIVE: The authors' objective was to characterize the effects of fluoxetine treatment on dexamethasone-induced growth hormone (GH) responses in depressed patients.

Regulation (effects) of Positive_regulation (dexamethasone-induced) of growth hormone associated with dexamethasone and fluoxetine

2) Confidence 0.45 Published 1995 Journal Am J Psychiatry Section Abstract Doc Link 7694914 Disease Relevance 0.07 Pain Relevance 0.30

To investigate the effects of endogenous testosterone (T) on the responsiveness of plasma growth hormone (GH) to central alpha 2 adrenergic stimulation, we administered clonidine (0.15 mg, p.o.) to 16 male patients with essential hypertension (EHT) and 13 age-matched male normotensive controls (NT).

Spec (investigate) Regulation (effects) of Spec (investigate) Positive_regulation (responsiveness) of GH in plasma associated with hypertension and clonidine

3) Confidence 0.44 Published 1989 Journal Clin Exp Hypertens A Section Abstract Doc Link 2612023 Disease Relevance 0.38 Pain Relevance 0.23

A number of agents such as oral GH-releasing peptides (GHRPs) increase GH secretion; they may be an alternative to GH treatment in the future.

Regulation (alternative) of Positive_regulation (treatment) of GH

4) Confidence 0.42 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8902544 Disease Relevance 0.45 Pain Relevance 0.14

To investigate the effects of endogenous testosterone (T) on the responsiveness of plasma growth hormone (GH) to central alpha 2 adrenergic stimulation, we administered clonidine (0.15 mg, p.o.) to 16 male patients with essential hypertension (EHT) and 13 age-matched male normotensive controls (NT).

Spec (investigate) Regulation (effects) of Spec (investigate) Positive_regulation (responsiveness) of plasma growth hormone in plasma associated with hypertension and clonidine

5) Confidence 0.39 Published 1989 Journal Clin Exp Hypertens A Section Abstract Doc Link 2612023 Disease Relevance 0.38 Pain Relevance 0.23

The effect of chronic administration of GH (8-24 months) on plasma GH responses to GHRH, clonidine and spontaneous GH secretion were studied in 17 NSD patients.

Regulation (effect) of Positive_regulation (responses) of GH in plasma associated with clonidine

6) Confidence 0.36 Published 1991 Journal Horm. Res. Section Abstract Doc Link 1806474 Disease Relevance 0 Pain Relevance 0.24

Note the GH increase after TRH (200 ?

Regulation (after) of Positive_regulation (increase) of GH

7) Confidence 0.26 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.41 Pain Relevance 0

These data are compatible with the hypothesis that beta-endorphin levels affect the GH response to GHRH in prepubertal children, but have no discernible effect on the GH response to GHRH in pubertal children.

Regulation (affect) of Positive_regulation (response) of GH

8) Confidence 0.21 Published 1992 Journal Endocr. Res. Section Abstract Doc Link 1576976 Disease Relevance 0.05 Pain Relevance 0

In the presence of naloxone, the GH response to MEL was completely abolished, whereas naloxone did not modify the pyridostigmine-induced GH increase.

Neg (not) Regulation (modify) of Positive_regulation (increase) of GH associated with narcan

9) Confidence 0.19 Published 1998 Journal Metab. Clin. Exp. Section Abstract Doc Link 9667227 Disease Relevance 0 Pain Relevance 0.34

We evaluated the effects of SU (6 mg s.c.) or placebo (PL) administration on GHRH (1 microgram/kg bw i.v.)

Regulation (effects) of Positive_regulation (-induced) of GH associated with sumatriptan

10) Confidence 0.18 Published 1997 Journal Recenti Prog Med Section Abstract Doc Link 9233053 Disease Relevance 0.07 Pain Relevance 0.87

The Sumatriptan-induced increase in GH responses to GHRH was dependent on the stimulus tested.

Regulation (dependent) of Positive_regulation (increase) of GH associated with sumatriptan

11) Confidence 0.09 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7775648 Disease Relevance 0.17 Pain Relevance 0.86

The influence of the histaminergic system on fentanyl (Fe)-induced growth hormone (GH) and prolactin (PRL) release as well as on Fe-induced increase of noradrenaline (NA) plasma levels has been studied in male volunteers.

Regulation (influence) of Positive_regulation (induced) of growth hormone in plasma associated with noradrenaline

12) Confidence 0.05 Published 1987 Journal Psychoneuroendocrinology Section Abstract Doc Link 3659227 Disease Relevance 0 Pain Relevance 0.34

General Comments

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